4,575 research outputs found
R-parity violating resonant stop production at the Large Hadron Collider
We have investigated the resonant production of a stop at the Large Hadron
Collider, driven by baryon number violating interactions in supersymmetry. We
work in the framework of minimal supergravity models with the lightest
neutralino being the lightest supersymmetric particle which decays within the
detector. We look at various dilepton and trilepton final states, with or
without b-tags. A detailed background simulation is performed, and all possible
decay modes of the lighter stop are taken into account. We find that higher
stop masses are sometimes easier to probe, through the decay of the stop into
the third or fourth neutralino and their subsequent cascades. We also comment
on the detectability of such signals during the 7 TeV run, where, as expected,
only relatively light stops can be probed. Our conclusion is that the resonant
process may be probed, at both 10 and 14 TeV, with the R-parity violating
coupling {\lambda}"_{312} as low as 0.05, for a stop mass of about 1 TeV. The
possibility of distinguishing between resonant stop production and
pair-production is also discussed.Comment: 20 pages, 4 figures, 6 tables; Version accepted by JHE
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Living in the past, present, and future: measuring temporal orientation with language
OBJECTIVE: Temporal orientation refers to individual differences in the relative emphasis one places on the past, present, or future, and is related to academic, financial, and health outcomes. We propose and evaluate a method for automatically measuring temporal orientation through language expressed on social media. METHOD: Judges rated the temporal orientation of 4,302 social media messages. We trained a classifier based on these ratings, which could accurately predict the temporal orientation of new messages in a separate validation set (accuracy/mean sensitivity = .72; mean specificity = .77). We used the classifier to automatically classify 1.3 million messages written by 5,372 participants (50% female, aged 13-48). Finally, we tested whether individual differences in past, present, and future orientation differentially related to gender, age, Big Five personality, satisfaction with life, and depressive symptoms. RESULTS: Temporal orientations exhibit several expected correlations with age, gender, and Big Five personality. More future-oriented people were older, more likely to be female, more conscientious, less impulsive, less depressed, and more satisfied with life; present orientation showed the opposite pattern. CONCLUSION: Language-based assessments can complement and extend existing measures of temporal orientation, providing an alternative approach and additional insights into language and personality relationships. This article is protected by copyright. All rights reserved.Support for this article was provided by grant #63597 from the Robert Wood Johnson Foundation (M. E. P. Seligman, PI) and by a grant from the Templeton Religion Trust (M.E.P. Seligman, H. A. Schwartz, L. H. Ungar, co-PIs)
Notch and MAML-1 Complexation Do Not Detectably Alter the DNA Binding Specificity of the Transcription Factor CSL
Canonical Notch signaling is initiated when ligand binding induces proteolytic release of the intracellular part of Notch (ICN) from the cell membrane. ICN then travels into the nucleus where it drives the assembly of a transcriptional activation complex containing the DNA-binding transcription factor CSL, ICN, and a specialized co-activator of the Mastermind family. A consensus DNA binding site motif for the CSL protein was previously defined using selection-based methods, but whether subsequent association of Notch and Mastermind-like proteins affects the DNA binding preferences of CSL has not previously been examined.Here, we utilized protein-binding microarrays (PBMs) to compare the binding site preferences of isolated CSL with the preferred binding sites of CSL when bound to the CSL-binding domains of all four different human Notch receptors. Measurements were taken both in the absence and in the presence of Mastermind-like-1 (MAML1). Our data show no detectable difference in the DNA binding site preferences of CSL before and after loading of Notch and MAML1 proteins.These findings support the conclusion that accrual of Notch and MAML1 promote transcriptional activation without dramatically altering the preferred sites of DNA binding, and illustrate the potential of PBMs to analyze the binding site preferences of multiprotein-DNA complexes
Feynman rules for the rational part of the Electroweak 1-loop amplitudes
We present the complete set of Feynman rules producing the rational terms of
kind R_2 needed to perform any 1-loop calculation in the Electroweak Standard
Model. Our results are given both in the 't Hooft-Veltman and in the Four
Dimensional Helicity regularization schemes. We also verified, by using both
the 't Hooft-Feynman gauge and the Background Field Method, a huge set of Ward
identities -up to 4-points- for the complete rational part of the Electroweak
amplitudes. This provides a stringent check of our results and, as a
by-product, an explicit test of the gauge invariance of the Four Dimensional
Helicity regularization scheme in the complete Standard Model at 1-loop. The
formulae presented in this paper provide the last missing piece for completely
automatizing, in the framework of the OPP method, the 1-loop calculations in
the SU(3) X SU(2) X U(1) Standard Model.Comment: Many thanks to Huasheng Shao for having recomputed, independently of
us, all of the effective vertices. Thanks to his help and by
comparing with an independent computation we performed in a general
gauge, we could fix, in the present version, the following formulae: the
vertex in Eq. (3.6), the vertex in Eq. (3.8),
Eqs (3.16), (3.17) and (3.18
Pathways to new drug discovery in neuropsychiatry
There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet unexpected drought in new drug development across the spectrum. In this commentary, the sources of this dilemma and potential avenues to redress the issue are explored. These include a critical review of diagnostic issues and of selection of participants for clinical trials, and the mechanisms for identifying new drugs and new drug targets. Historically, the vast majority of agents have been discovered serendipitously or have been modifications of existing agents. Serendipitous discoveries, based on astute clinical observation or data mining, remain a valid option, as is illustrated by the suggestion in the paper by Wahlqvist and colleagues that treatment with sulfonylurea and metformin reduces the risk of affective disorder. However, the identification of agents targeting disorder-related biomarkers is currently proving particularly fruitful. There is considerable hope for genetics as a purist, pathophysiologically valid pathway to drug discovery; however, it is unclear whether the science is ready to meet this promise. Fruitful paradigms will require a break from the orthodoxy, and creativity and risk may well be the fingerprints of success
Time to incorporate time in cost-effectiveness analysis
Cost-effectiveness analysis as a means to evaluate medical innovations has become well accepted in the UK and several other Western countries. An important assumption underlying this method is that costs and effects are constant over time. In reality, however, and especially in the short run, variations in costs and effects are likely to occur. These variations can lead to considerable deviations from the outcome of a conventional economic evaluation, which in turn may lead to serious implementation problems at a local level. Taking time into account explicitly in economic evaluations in health care may enhance their utility for both societal and local decision making, and may ultimately smooth the adoption of new and basically cost-effective health care technologies
MINLO: Multi-scale improved NLO
In the present work we consider the assignment of the factorization and
renormalization scales in hadron collider processes with associated jet
production, at next-to-leading order (NLO) in perturbation theory. We propose a
simple, definite prescription to this end, including Sudakov form factors to
consistently account for the distinct kinematic scales occuring in such
collisions. The scheme yields results that are accurate at NLO and, for a large
class of observables, it resums to all orders the large logarithms that arise
from kinematic configurations involving disparate scales. In practical terms
the method is most simply understood as an NLO extension of the matrix element
reweighting procedure employed in tree level matrix element-parton shower
merging algorithms. By way of a proof-of-concept, we apply the method to Higgs
and Z boson production in association with up to two jets.Comment: 27 pages, 17 figure
Gaugino production in proton-proton collisions at a center-of-mass energy of 8 TeV
Motivated by hints for a light Standard Model-like Higgs boson and a shift in
experimental attention towards electroweak supersymmetry particle production at
the CERN LHC, we update in this paper our precision predictions at
next-to-leading order of perturbative QCD matched to resummation at the
next-to-leading logarithmic accuracy for direct gaugino pair production in
proton-proton collisions with a center-of-mass energy of 8 TeV. Tables of total
cross sections are presented together with the corresponding scale and parton
density uncertainties for benchmark points adopted recently by the experimental
collaborations, and figures are presented for up-to-date model lines attached
to them. Since the experimental analyses are currently obtained with parton
showers matched to multi-parton matrix elements, we also analyze the precision
of this procedure by comparing invariant-mass and transverse-momentum
distributions obtained in this way to those obtained with threshold and
transverse-momentum resummation.Comment: 28 pages, 7 figures, 9 tables; version to appear in JHE
Energy drink use, problem drinking and drinking motives in a diverse sample of Alaskan college students
Background. Recent research has identified the use of caffeinated energy drinks as a common, potentially risky behaviour among college students that is linked to alcohol misuse and consequences. Research also suggests that energy drink consumption is related to other risky behaviours such as tobacco use, marijuana use and risky sexual activity. Objective. This research sought to examine the associations between frequency of energy drink consumption and problematic alcohol use, alcohol-related consequences, symptoms of alcohol dependence and drinking motives in an ethnically diverse sample of college students in Alaska. We also sought to examine whether ethnic group moderated these associations in the present sample of White, Alaska Native/American Indian and other ethnic minority college students. Design. A paper-and-pencil self-report questionnaire was completed by a sample of 298 college students. Analysis of covariance (ANCOVA) was used to examine the effects of energy drink use, ethnic group and energy drink by ethnic group interactions on alcohol outcomes after controlling for variance attributed to gender, age and frequency of binge drinking. Results. Greater energy drink consumption was significantly associated with greater hazardous drinking, alcohol consequences, alcohol dependence symptoms, drinking for enhancement motives and drinking to cope. There were no main effects of ethnic group, and there were no significant energy drink by ethnic group interactions. Conclusion. These findings replicate those of other studies examining the associations between energy drink use and alcohol problems, but contrary to previous research we did not find ethnic minority status to be protective. It is possible that energy drink consumption may serve as a marker for other health risk behaviours among students of various ethnic groups
Higgs Physics: Theory
I review the theoretical aspects of the physics of Higgs bosons, focusing on
the elements that are relevant for the production and detection at present
hadron colliders. After briefly summarizing the basics of electroweak symmetry
breaking in the Standard Model, I discuss Higgs production at the LHC and at
the Tevatron, with some focus on the main production mechanism, the gluon-gluon
fusion process, and summarize the main Higgs decay modes and the experimental
detection channels. I then briefly survey the case of the minimal
supersymmetric extension of the Standard Model. In a last section, I review the
prospects for determining the fundamental properties of the Higgs particles
once they have been experimentally observed.Comment: 21 pages, 15 figures. Talk given at the XXV International Symposium
on Lepton Photon Interactions at High Energies (Lepton Photon 11), 22-27
August 2011, Mumbai, Indi
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