1,791 research outputs found
Altered distribution of mucosal NK cells during HIV infection.
The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s) by which they mediate antiviral activity in the gut is unclear. Here, we show that two distinct subsets of NK cells exist in the gut, one localized to intraepithelial spaces (intraepithelial lymphocytes, IELs) and the other to the lamina propria (LP). The frequency of both subsets of NK cells was reduced in chronic infection, whereas IEL NK cells remained stable in spontaneous controllers with protective killer immunoglobulin-like receptor/human leukocyte antigen genotypes. Both IEL and LP NK cells were significantly expanded in immunological non-responsive patients, who incompletely recovered CD4+ T cells on highly active antiretroviral therapy (HAART). These data suggest that both IEL and LP NK cells may expand in the gut in an effort to compensate for compromised CD4+ T-cell recovery, but that only IEL NK cells may be involved in providing durable control of HIV in the gut
PGB pair production at LHC and ILC as a probe of the topcolor-assisted technicolor models
The topcolor-assisted technicolor (TC2) model predicts some light pseudo
goldstone bosons (PGBs), which may be accessible at the LHC or ILC. In this
work we study the pair productions of the charged or neutral PGBs at the LHC
and ILC. For the productions at the LHC we consider the processes proceeding
through gluon-gluon fusion and quark-antiquark annihilation, while for the
productions at the ILC we consider both the electron-positron collision and the
photon-photon collision. We find that in a large part of parameter space the
production cross sections at both colliders can be quite large compared with
the low standard model backgrounds. Therefore, in future experiments these
productions may be detectable and allow for probing TC2 model.Comment: 26 pages, 16 figures. slight changes in the text; notations for
curves changed; references adde
P16-41. Evidence for in vivo immune selection pressure exerted by HLA class I restricted CTL responses to anti-sense encoded HIV sequences
Colored Resonant Signals at the LHC: Largest Rate and Simplest Topology
We study the colored resonance production at the LHC in a most general
approach. We classify the possible colored resonances based on group theory
decomposition, and construct their effective interactions with light partons.
The production cross section from annihilation of valence quarks or gluons may
be on the order of 400 - 1000 pb at LHC energies for a mass of 1 TeV with
nominal couplings, leading to the largest production rates for new physics at
the TeV scale, and simplest event topology with dijet final states. We apply
the new dijet data from the LHC experiments to put bounds on various possible
colored resonant states. The current bounds range from 0.9 to 2.7 TeV. The
formulation is readily applicable for future searches including other decay
modes.Comment: 29 pages, 9 figures. References updated and additional K-factors
include
A novel regulatory circuit specifies cell fate in the Arabidopsis root epidermis
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75165/1/j.1399-3054.2006.00606.x.pd
Vertical current induced domain wall motion in MgO-based magnetic tunnel junction with low current densities
Shifting electrically a magnetic domain wall (DW) by the spin transfer
mechanism is one of the future ways foreseen for the switching of spintronic
memories or registers. The classical geometries where the current is injected
in the plane of the magnetic layers suffer from a poor efficiency of the
intrinsic torques acting on the DWs. A way to circumvent this problem is to use
vertical current injection. In that case, theoretical calculations attribute
the microscopic origin of DW displacements to the out-of-plane (field-like)
spin transfer torque. Here we report experiments in which we controllably
displace a DW in the planar electrode of a magnetic tunnel junction by vertical
current injection. Our measurements confirm the major role of the out-of-plane
spin torque for DW motion, and allow to quantify this term precisely. The
involved current densities are about 100 times smaller than the one commonly
observed with in-plane currents. Step by step resistance switching of the
magnetic tunnel junction opens a new way for the realization of spintronic
memristive devices
RG-improved single-particle inclusive cross sections and forward-backward asymmetry in production at hadron colliders
We use techniques from soft-collinear effective theory (SCET) to derive
renormalization-group improved predictions for single-particle inclusive (1PI)
observables in top-quark pair production at hadron colliders. In particular, we
study the top-quark transverse-momentum and rapidity distributions, the
forward-backward asymmetry at the Tevatron, and the total cross section at
NLO+NNLL order in resummed perturbation theory and at approximate NNLO in fixed
order. We also perform a detailed analysis of power corrections to the leading
terms in the threshold expansion of the partonic hard-scattering kernels. We
conclude that, although the threshold expansion in 1PI kinematics is
susceptible to numerically significant power corrections, its predictions for
the total cross section are in good agreement with those obtained by
integrating the top-pair invariant-mass distribution in pair invariant-mass
kinematics, as long as a certain set of subleading terms appearing naturally
within the SCET formalism is included.Comment: 55 pages, 14 figures, 6 table
Z' signals in polarised top-antitop final states
We study the sensitivity of top-antitop samples produced at all energy stages
of the Large Hadron Collider (LHC) to the nature of an underlying Z' boson, in
presence of full tree level standard model (SM) background effects and relative
interferences. We concentrate on differential mass spectra as well as both
spatial and spin asymmetries thereby demonstrating that exploiting combinations
of these observables will enable one to distinguish between sequential Z's and
those pertaining to Left-Right symmetric models as well as E6 inspired ones,
assuming realistic final state reconstruction efficiencies and error estimates.Comment: 21 pages, 6 colour figures, 10 table
ACL reconstruction with unicondylar replacement in knee with functional instability and osteoarthritis
Severe symptomatic osteoarthritis in young and active patients with pre-existing deficiency of the anterior cruciate ligament and severe functionally instability is a difficult subgroup to manage. There is considerable debate regarding management of young patients with isolated unicompartment osteoarthritis and concomitant ACL deficiency. A retrospective analysis of was done in 9 patients with symptomatic osteoarthritis with ACL deficiencies and functional instability that were treated with unicompartment knee arthroplasty and ACL reconstruction between April 2002 and June 2005. The average arc of flexion was 119° (range 85° to 135°) preoperatively and 125° (range 105° to 140°). There were no signs of instability during the follow up of patients. No patients in this group were reoperated. In this small series we have shown that instability can be corrected and pain relieved by this combined procedure
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