564 research outputs found
Ion-sensing using chemically-modified ISFETs
Synthetic macrocyclic polyether ion receptors are the active components for the selective and sensitive detection of potassium ions in chemical sensors based on modified ISFETs.\ud
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Covalent chemical anchoring of the sensing membrane to the gate oxide of the ISFET is essential in order to increase the lifetime of the sensor system to more than three months
Determining the density of states for classical statistical models: A random walk algorithm to produce a flat histogram
We describe an efficient Monte Carlo algorithm using a random walk in energy
space to obtain a very accurate estimate of the density of states for classical
statistical models. The density of states is modified at each step when the
energy level is visited to produce a flat histogram. By carefully controlling
the modification factor, we allow the density of states to converge to the true
value very quickly, even for large systems. This algorithm is especially useful
for complex systems with a rough landscape since all possible energy levels are
visited with the same probability. In this paper, we apply our algorithm to
both 1st and 2nd order phase transitions to demonstrate its efficiency and
accuracy. We obtained direct simulational estimates for the density of states
for two-dimensional ten-state Potts models on lattices up to
and Ising models on lattices up to . Applying this approach to
a 3D spin glass model we estimate the internal energy and entropy at
zero temperature; and, using a two-dimensional random walk in energy and
order-parameter space, we obtain the (rough) canonical distribution and energy
landscape in order-parameter space. Preliminary data suggest that the glass
transition temperature is about 1.2 and that better estimates can be obtained
with more extensive application of the method.Comment: 22 pages (figures included
Проведение подготовительных горных выработок с анкерной крепью
В цій статті вперше визначені головні чинники та умови застосування конструкцій анкерного кріплення для виробок, що проводяться для експлуатації в зоні та поза зоною впливу очисних робіт. Наведено типові схеми розташування анкерів у цих конструкціях для виробок, що зберігаються для повторного застосування, та порядок їх вибору.This article was first identified key factors and conditions of using of roof bolting construction
for mine working carried out for using in the zone and outside the zone of impact of treatment
works. The typical schemes of anchors location in these constructions for the mine workings, saving for reuse, and the order of their choice were shown
Dynamics of evaporative cooling in magnetically trapped atomic hydrogen
We study the evaporative cooling of magnetically trapped atomic hydrogen on
the basis of the kinetic theory of a Bose gas. The dynamics of trapped atoms is
described by the coupled differential equations, considering both the
evaporation and dipolar spin relaxation processes. The numerical time-evolution
calculations quantitatively agree with the recent experiment of Bose-Einstein
condensation with atomic hydrogen. It is demonstrated that the balance between
evaporative cooling and heating due to dipolar relaxation limits the number of
condensates to 9x10^8 and the corresponding condensate fraction to a small
value of 4% as observed experimentally.Comment: 5 pages, REVTeX, 3 eps figures, Phys. Rev. A in pres
Curved Tails in Polymerization-Based Bacterial Motility
The curved actin ``comet-tail'' of the bacterium Listeria monocytogenes is a
visually striking signature of actin polymerization-based motility. Similar
actin tails are associated with Shigella flexneri, spotted-fever Rickettsiae,
the Vaccinia virus, and vesicles and microspheres in related in vitro systems.
We show that the torque required to produce the curvature in the tail can arise
from randomly placed actin filaments pushing the bacterium or particle. We find
that the curvature magnitude determines the number of actively pushing
filaments, independent of viscosity and of the molecular details of force
generation. The variation of the curvature with time can be used to infer the
dynamics of actin filaments at the bacterial surface.Comment: 8 pages, 2 figures, Latex2
Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high-risk donor livers
Ex situ normothermic machine perfusion (NMP) is increasingly used for viability assessment of high-risk donor livers, whereas dual hypothermic oxygenated machine perfusion (DHOPE) reduces ischemia-reperfusion injury. We aimed to resuscitate and test the viability of initially-discarded, high-risk donor livers using sequential DHOPE and NMP with two different oxygen carriers: an artificial hemoglobin-based oxygen carrier (HBOC) or red blood cells (RBC). In a prospective observational cohort study of 54 livers that underwent DHOPE-NMP, the first 18 procedures were performed with a HBOC-based perfusion solution and the subsequent 36 procedures were performed with an RBC-based perfusion solution for the NMP phase. All but one livers were derived from extended criteria donation after circulatory death donors, with a median donor risk index of 2.84 (IQR 2.52–3.11). After functional assessment during NMP, 34 livers (63% utilization), met the viability criteria and were transplanted. One-year graft and patient survival were 94% and 100%, respectively. Post-transplant cholangiopathy occurred in 1 patient (3%). There were no significant differences in utilization rate and post-transplant outcomes between the HBOC and RBC group. Ex situ machine perfusion using sequential DHOPE-NMP for resuscitation and viability assessment of high-risk donor livers results in excellent transplant outcomes, irrespective of the oxygen carrier used.</p
Sequential Hypothermic and Normothermic Machine Perfusion Enables Safe Transplantation of High-risk Donor Livers
Ex situ normothermic machine perfusion (NMP) is increasingly used for viability assessment of high-risk donor livers, whereas dual hypothermic oxygenated machine perfusion (DHOPE) reduces ischemia-reperfusion injury. We aimed to resuscitate and test the viability of initially-discarded, high-risk donor livers using sequential DHOPE and NMP with two different oxygen carriers: an artificial hemoglobin-based oxygen carrier (HBOC) or red blood cells (RBC). In a prospective observational cohort study of 54 livers that underwent DHOPE-NMP, the first 18 procedures were performed with a HBOC-based perfusion solution and the subsequent 36 procedures were performed with an RBC-based perfusion solution for the NMP phase. All but one livers were derived from extended criteria donation after circulatory death donors, with a median donor risk index of 2.84 (IQR 2.52-3.11). After functional assessment during NMP, 34 livers (63% utilization), met the viability criteria and were transplanted. One-year graft and patient survival were 94% and 100%, respectively. Post-transplant cholangiopathy occurred in 1 patient (3%). There were no significant differences in utilization rate and post-transplant outcomes between the HBOC and RBC group. Ex situ machine perfusion using sequential DHOPE-NMP for resuscitation and viability assessment of high-risk donor livers results in excellent transplant outcomes, irrespective of the oxygen carrier used
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