Large wood debris that clogged bridges followed by a sudden release: the 2019 flash flood in Catalonia

The aim is the reconstruction of the October 2019 flash flood, that was documented through extensive field work: rainfall (300 mm in just a few hours), flood marks, times of flood passage and witnesses' snapshots and reports, channel changes, log drift (20,000 trees) and woody debris at bridges, as well as large damage and six fatalities. The methods are: hydrological model built for the rainfall-runoff in the basin and the flood routing in the river, use of hydraulic principles such as flow at waterfalls, flow against obstacles (trees), etc. and finally 1D/2D free surface numerical models. The uppermost 100 km2 produced discharges of 700 m3/s (up to 50 m3/s/km2, locally). Three bridges failed, but their cascading failure (when one failure triggers the next one downstream) was not proved. The main channel widened more than 10 times, dragging away soil and vegetation like a bulldozer. The resulting large wood debris that clogged two bridges worsened the inundation. An anomalous flow downstream, probably a surge of around 1090 m3/s, due to the failure of a woody jam at a narrow bridge, took two lives. Water Authority is now warning flood planners that vegetated, torrential basins may cause catastrophic floods in the valley towns, if their narrow bridges are sensitive to woody debris.Catalan Water Authority and its Tarragona officers, Meteoprades and Fons Signatus, Joan March and a number of witnesses. The UPC's contribution was funded by the contract CTN2000029 of the “Agència Catalana de l′Aigua”. The UB's contribution has been developed within the framework of the AGORA project, funded by the "Agència Catalana de l′Aigua". Our thanks to the "Museu de la Vida Rural", in l′Espluga de Francolí, and all the citizens who contributed to the return of experience. The UIB's research has been supported by the Ministerio de Ciencia, Innovación y Universidades (CGL2017-82868-R and PID2020-113036RB-I00/AEI/10.13039/501100011033 research projects, which are partially supported by the European Regional Development Funds).Peer ReviewedPostprint (published version

Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs

Current strategies for the mass administration of antimalarial drugs demand oral formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas recommendations for future interventions stress the importance of also targeting the transmission stages of the parasite as it passes between humans and mosquitoes. Orally administered polyamidoamine (PAA) nanoparticles conjugated to chloroquine reached the blood circulation and cured Plasmodium yoelii-infected mice, slightly improving the activity of the free drug and inducing in the animals immunity against malaria. Liquid chromatography with tandem mass spectrometry analysis of affinity chromatography-purified PAA ligands suggested a high adhesiveness of PAAs to Plasmodium falciparum proteins, which might be the mechanism responsible for the preferential binding of PAAs to Plasmodium-infected erythrocytes vs. non-infected red blood cells. The weak antimalarial activity of some PAAs was found to operate through inhibition of parasite invasion, whereas the observed polymer intake by macrophages indicated a potential of PAAs for the treatment of certain coinfections such as Plasmodium and Leishmania. When fluorescein-labeled PAAs were fed to females of the malaria mosquito vectors Anopheles atroparvus and Anopheles gambiae, persistent fluorescence was observed in the midgut and in other insect's tissues. These results present PAAs as a versatile platform for the encapsulation of orally administered antimalarial drugs and for direct administration of antimalarials to mosquitoes, targeting mosquito stages of Plasmodiu

MPGM per a la renovació de les àrees industrials del Poble Nou : Barcelona

Sol·licitant de l’informe: Gerència d'Urbanism

A water availability prediction system for water management

In this work we present a Water Availability Prediction System [WAPS] developed and implemented within two EU-FP7 projects: UrbanWater and WatERP. The aim of the WAPS is to provide information for management purposes, and as a source of information for other modules of the Decision Support Systems integrating the project platforms. General description of the WAPS, including data sources needed, processing algorithms and techniques used, and implementation examples are presented.Postprint (published version

A water availability prediction system for water management

In this work we present a Water Availability Prediction System [WAPS] developed and implemented within two EU-FP7 projects: UrbanWater and WatERP. The aim of the WAPS is to provide information for management purposes, and as a source of information for other modules of the Decision Support Systems integrating the project platforms. General description of the WAPS, including data sources needed, processing algorithms and techniques used, and implementation examples are presented

Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs

Current strategies for the mass administration of antimalarial drugs demand oral formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas recommendations for future interventions stress the importance of also targeting the transmission stages of the parasite as it passes between humans and mosquitoes. Orally administered polyamidoamine (PAA) nanoparticles conjugated to chloroquine reached the blood circulation and cured Plasmodium yoelii-infected mice, slightly improving the activity of the free drug and inducing in the animals immunity against malaria. Liquid chromatography with tandem mass spectrometry analysis of affinity chromatography-purified PAA ligands suggested a high adhesiveness of PAAs to Plasmodium falciparum proteins, which might be the mechanism responsible for the preferential binding of PAAs to Plasmodium-infected erythrocytes vs. non-infected red blood cells. The weak antimalarial activity of some PAAs was found to operate through inhibition of parasite invasion, whereas the observed polymer intake by macrophages indicated a potential of PAAs for the treatment of certain coinfections such as Plasmodium and Leishmania. When fluorescein-labeled PAAs were fed to females of the malaria mosquito vectors Anopheles atroparvus and Anopheles gambiae, persistent fluorescence was observed in the midgut and in other insect's tissues. These results present PAAs as a versatile platform for the encapsulation of orally administered antimalarial drugs and for direct administration of antimalarials to mosquitoes, targeting mosquito stages of Plasmodiu

Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs

Current strategies for the mass administration of antimalarial drugs demand oral formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas recommendations for future interventions stress the importance of also targeting the transmission stages of the parasite as it passes between humans and mosquitoes. Orally administered polyamidoamine (PAA) nanoparticles conjugated to chloroquine reached the blood circulation and cured Plasmodium yoelii-infected mice, slightly improving the activity of the free drug and inducing in the animals immunity against malaria. Liquid chromatography with tandem mass spectrometry analysis of affinity chromatography-purified PAA ligands suggested a high adhesiveness of PAAs to Plasmodium falciparum proteins, which might be the mechanism responsible for the preferential binding of PAAs to Plasmodium-infected erythrocytes vs. non-infected red blood cells. The weak antimalarial activity of some PAAs was found to operate through inhibition of parasite invasion, whereas the observed polymer intake by macrophages indicated a potential of PAAs for the treatment of certain coinfections such as Plasmodium and Leishmania. When fluorescein-labeled PAAs were fed to females of the malaria mosquito vectors Anopheles atroparvus and Anopheles gambiae, persistent fluorescence was observed in the midgut and in other insect's tissues. These results present PAAs as a versatile platform for the encapsulation of orally administered antimalarial drugs and for direct administration of antimalarials to mosquitoes, targeting mosquito stages of Plasmodiu

Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain.

To analyse the characteristics and predictors of death in hospitalized patients with coronavirus disease 2019 (COVID-19) in Spain. A retrospective observational study was performed of the first consecutive patients hospitalized with COVID-19 confirmed by real-time PCR assay in 127 Spanish centres until 17 March 2020. The follow-up censoring date was 17 April 2020. We collected demographic, clinical, laboratory, treatment and complications data. The primary endpoint was all-cause mortality. Univariable and multivariable Cox regression analyses were performed to identify factors associated with death. Of the 4035 patients, male subjects accounted for 2433 (61.0%) of 3987, the median age was 70 years and 2539 (73.8%) of 3439 had one or more comorbidity. The most common symptoms were a history of fever, cough, malaise and dyspnoea. During hospitalization, 1255 (31.5%) of 3979 patients developed acute respiratory distress syndrome, 736 (18.5%) of 3988 were admitted to intensive care units and 619 (15.5%) of 3992 underwent mechanical ventilation. Virus- or host-targeted medications included lopinavir/ritonavir (2820/4005, 70.4%), hydroxychloroquine (2618/3995, 65.5%), interferon beta (1153/3950, 29.2%), corticosteroids (1109/3965, 28.0%) and tocilizumab (373/3951, 9.4%). Overall, 1131 (28%) of 4035 patients died. Mortality increased with age (85.6% occurring in older than 65 years). Seventeen factors were independently associated with an increased hazard of death, the strongest among them including advanced age, liver cirrhosis, low age-adjusted oxygen saturation, higher concentrations of C-reactive protein and lower estimated glomerular filtration rate. Our findings provide comprehensive information about characteristics and complications of severe COVID-19, and may help clinicians identify patients at a higher risk of death