29 research outputs found
Tuberculosis Incidence in Prisons: A Systematic Review
A systematic review by Iacopo Baussano and colleagues synthesizes published research to show that improved tuberculosis (TB) control in prisons could significantly reduce the burden of TB both inside and outside prisons
Selection of a Suitable Physical Form and Development of a Crystallization Process for a PDE10A Inhibitor Exhibiting Enantiotropic Polymorphism
AMG 579 (<b>1</b>) is a potent
and selective phosphodiesterase
10 (PDE10A) inhibitor selected for clinical development for the treatment
of schizophrenia. Extensive polymorph and salt screening identified
two free-base anhydrous polymorphs (Form 1 and Form 2) that are viable
for further development. Crystal structures of these two polymorphs
were determined by single-crystal X-ray study. Form 1 and Form 2 are
enantiotropically related with the transition temperature between
190 and 210 °C. After full characterization, quality attributes
were evaluated, and Form 2, the thermodynamically more stable form
at room temperature, was selected for clinical development. A crystallization
process for Form 2 was developed, and in situ Raman spectroscopy was
used as a PAT tool to monitor and control the physical form. Use of
this integrated control strategy allowed access to multikilogram quantities
of AMG 579 in the desired form