29 research outputs found
Tuberculosis Incidence in Prisons: A Systematic Review
Get PDFA systematic review by Iacopo Baussano and colleagues synthesizes published research to show that improved tuberculosis (TB) control in prisons could significantly reduce the burden of TB both inside and outside prisons
Enantioselective Cross-Coupling of Anhydrides with Organozinc Reagents: The Controlled Formation of Carbon−Carbon Bonds through the Nucleophilic Interception of Metalacycles
No full textCriminal Tax Investigation in the United States: Focusing on the role and function of the Internal Revenue Service
No full textSelection of a Suitable Physical Form and Development of a Crystallization Process for a PDE10A Inhibitor Exhibiting Enantiotropic Polymorphism
No full textAMG 579 (<b>1</b>) is a potent
and selective phosphodiesterase
10 (PDE10A) inhibitor selected for clinical development for the treatment
of schizophrenia. Extensive polymorph and salt screening identified
two free-base anhydrous polymorphs (Form 1 and Form 2) that are viable
for further development. Crystal structures of these two polymorphs
were determined by single-crystal X-ray study. Form 1 and Form 2 are
enantiotropically related with the transition temperature between
190 and 210 °C. After full characterization, quality attributes
were evaluated, and Form 2, the thermodynamically more stable form
at room temperature, was selected for clinical development. A crystallization
process for Form 2 was developed, and in situ Raman spectroscopy was
used as a PAT tool to monitor and control the physical form. Use of
this integrated control strategy allowed access to multikilogram quantities
of AMG 579 in the desired form
Nickel-Mediated Decarbonylative Cross-Coupling of Phthalimides with in Situ Generated Diorganozinc Reagents
No full textDecarbonylative Cross-Coupling of Cyclic Anhydrides: Introducing Stereochemistry at an sp 3
No full textMolecular epidemiology of penicillinase-producing Neisseria gonorrhoeae isolates in France
No full text
In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase–producing Klebsiella pneumoniae
No full textMild and Efficient Synthesis of Carboxylic Acid Anhydrides from Carboxylic Acids and Triazine Coupling Reagents
No full text
