Entropic sampling dynamics of the globally-coupled kinetic Ising model

The entropic sampling dynamics based on the reversible information transfer to and from the environment is applied to the globally coupled Ising model in the presence of an oscillating magnetic field. When the driving frequency is low enough, coherence between the magnetization and the external magnetic field is observed; such behavior tends to weaken with the system size. The time-scale matching between the intrinsic time scale, defined in the absence of the external magnetic field, and the extrinsic time scale, given by the inverse of the driving frequency, is used to explain the observed coherence behavior.Comment: 8 page

LHC Signature of Mirage Mediation

We study LHC phenomenology of mirage mediation scenario in which anomaly and modulus contributions to soft SUSY breaking terms are comparable to each other. A Monte Carlo study of mirage mediation, with model parameters $\alpha=1$,$M_0=500$ GeV, $n_M=1/2$, $n_H=1$ and $\rm{tan}\beta=10$, is presented. It is shown that masses of supersymmetric particles can be measured in a model independent way, providing information on SUSY breaking sector. In particular, the mass ratio of gluino to the lightest neutralino for the benchmark scenario is determined to be 1.9 \lesssim m_{\tildeg}/m_{\tilde\chi_1^0} \lesssim 3.1, well reproducing theoretical input value of $m_{\tilde g}/m_{\tilde\chi_1^0} \simeq 2.5$ which is quite distinctive from the predictions $m_{\tilde g}/m_{\tilde\chi_1^0} \gtrsim 6$ of other SUSY scenarios in which gaugino masses are unified at the GUT scale. The model parameters of mirage mediation can be also determined from various kinematic distributions

Spatiotemporal Stochastic Resonance in Fully Frustrated Josephson Ladders

We consider a Josephson-junction ladder in an external magnetic field with half flux quantum per plaquette. When driven by external currents, periodic in time and staggered in space, such a fully frustrated system is found to display spatiotemporal stochastic resonance under the influence of thermal noise. Such resonance behavior is investigated both numerically and analytically, which reveals significant effects of anisotropy and yields rich physics.Comment: 8 pages in two columns, 8 figures, to appear in Phys. Rev.

Vortex Fluctuations in High-Tc Films: Flux Noise Spectrum and Complex Impedance

The flux noise spectrum and complex impedance for a 500 {\AA} thick YBCO film are measured and compared with predictions for two dimensional vortex fluctuations. It is verified that the complex impedance and the flux noise spectra are proportional to each other, that the logarithm of the flux noise spectra for different temperatures has a common tangent with slope $\approx -1$, and that the amplitude of the noise decreases as $d^{-3}$, where $d$ is the height above the film at which the magnetic flux is measured. A crossover from normal to anomalous vortex diffusion is indicated by the measurements and is discussed in terms of a two-dimensional decoupling.Comment: 5 pages including 4 figures in two columns, to appear in Phys. Rev. Let

Exciton-driven antiferromagnetic metal in a correlated van der Waals insulator

Collective excitations of bound electron-hole pairs -- known as excitons -- are ubiquitous in condensed matter, emerging in systems as diverse as band semiconductors, molecular crystals, and proteins. Recently, their existence in strongly correlated electron materials has attracted increasing interest due to the excitons' unique coupling to spin and orbital degrees of freedom. The non-equilibrium driving of such dressed quasiparticles offers a promising platform for realizing unconventional many-body phenomena and phases beyond thermodynamic equilibrium. Here, we achieve this in the van der Waals correlated insulator NiPS$_3$ by photoexciting its newly discovered spin-orbit-entangled excitons that arise from Zhang-Rice states. By monitoring the time evolution of the terahertz conductivity, we observe the coexistence of itinerant carriers produced by exciton dissociation and the long-wavelength antiferromagnetic magnon that coherently precesses in time. These results demonstrate the emergence of a transient metallic state that preserves long-range antiferromagnetism, a phase that cannot be reached by simply tuning the temperature. More broadly, our findings open an avenue toward the exciton-mediated optical manipulation of magnetism.Comment: 24 pages, 23 figure

Family name distributions: Master equation approach

Although cumulative family name distributions in many countries exhibit power-law forms, there also exist counterexamples. The origin of different family name distributions across countries is discussed analytically in the framework of a population dynamics model. Combined with empirical observations made, it is suggested that those differences in distributions are closely related with the rate of appearance of new family names.Comment: 7 pages, 8 figure

Dynamic instabilities induced by asymmetric influence: Prisoners' dilemma game on small-world networks

A two-dimensional small-world type network, subject to spatial prisoners' dilemma dynamics and containing an influential node defined as a special node with a finite density of directed random links to the other nodes in the network, is numerically investigated. It is shown that the degree of cooperation does not remain at a steady state level but displays a punctuated equilibrium type behavior manifested by the existence of sudden breakdowns of cooperation. The breakdown of cooperation is linked to an imitation of a successful selfish strategy of the influential node. It is also found that while the breakdown of cooperation occurs suddenly, the recovery of it requires longer time. This recovery time may, depending on the degree of steady state cooperation, either increase or decrease with an increasing number of long range connections.Comment: 5 pages, 6 figure

Overnight switch from ropinirole to transdermal rotigotine patch in patients with Parkinson disease

<p>Abstract</p> <p>Background</p> <p>A recent trial involving predominantly Caucasian subjects with Parkinson Disease (PD) showed switching overnight from an oral dopaminergic agonist to the rotigotine patch was well tolerated without loss of efficacy. However, no such data have been generated for Korean patients.</p> <p>Methods</p> <p>This open-label multicenter trial investigated PD patients whose symptoms were not satisfactorily controlled by ropinirole, at a total daily dose of 3 mg to 12 mg, taken as monotherapy or as an adjunct to levodopa. Switching treatment from oral ropinirole to transdermal rotigotine was carried out overnight, with a dosage ratio of 1.5:1. After a 28-day treatment period, the safety and tolerability of switching was evaluated. Due to the exploratory nature of this trial, the effects of rotigotine on motor and nonmotor symptoms of PD were analyzed in a descriptive manner.</p> <p>Results</p> <p>Of the 116 subjects who received at least one treatment, 99 (85%) completed the 28-day trial period. Dose adjustments were required for 11 subjects who completed the treatment period. A total of 76 treatment-emergent adverse events (AEs) occurred in 45 subjects. No subject experienced a serious AE. Thirteen subjects discontinued rotigotine prematurely due to AEs. Efficacy results suggested improvements in both motor and nonmotor symptoms and quality of life after switching. Fifty-two subjects (46%) agreed that they preferred using the patch over oral medications, while 31 (28%) disagreed.</p> <p>Conclusions</p> <p>Switching treatment overnight from oral ropinirole to transdermal rotigotine patch, using a dosage ratio of 1.5:1, was well tolerated in Korean patients with no loss of efficacy.</p> <p>Trial registration</p> <p>This trial is registered with the ClincalTrails.gov Registry (<a href="http://www.clinicaltrials.gov/ct2/show/NCT00593606">NCT00593606</a>).</p

Kinase inhibitor pulldown assay identifies a chemotherapy response signature in triple-negative breast cancer based on purine-binding proteins

UNLABELLED: Triple-negative breast cancer (TNBC) constitutes 10%-15% of all breast tumors. The current standard of care is multiagent chemotherapy, which is effective in only a subset of patients. The original objective of this study was to deploy a mass spectrometry (MS)-based kinase inhibitor pulldown assay (KIPA) to identify kinases elevated in non-pCR (pathologic complete response) cases for therapeutic targeting. Frozen optimal cutting temperature compound-embedded core needle biopsies were obtained from 43 patients with TNBC before docetaxel- and carboplatin-based neoadjuvant chemotherapy. KIPA was applied to the native tumor lysates that were extracted from samples with high tumor content. Seven percent of all identified proteins were kinases, and none were significantly associated with lack of pCR. However, among a large population of off-target purine-binding proteins (PBP) identified, seven were enriched in pCR-associated samples ( SIGNIFICANCE: The identification of pretreatment predictive biomarkers for pCR in response to neoadjuvant chemotherapy would advance precision treatment for TNBC. To complement standard proteogenomic discovery profiling, a KIPA was deployed and unexpectedly identified a seven-member non-kinase PBP pCR-associated signature. Individual members served diverse pathways including IFN gamma response, nuclear import of DNA repair proteins, and cell death