Promoção de intervenções não-farmacológicas para tratar hipertensão arterial

In the first part of this review, definition, prevalence, historical evolution and general principles of nonpharmacologic treatment of hypertesion are discussed. Then, rational basis and behavioural strategies to relieve reduction of obesity, ingestion of salt or alcohol, sedentarism, emotional stress and smoking are presented. Finally, the role of other dietary factors and combined therapy is considered, specially the integration of these therapies in a multidisciplinary approache to the patient with high blood pressure.Na primeira parte desta revisão, discutem-se a definição, prevalência, evolução histórica e os princípios gerais do tratamento não-farmacológico da hipertensão arterial. Em seguida, apresenta-se a base principal e as estratégias comportamentais para redução da obesidade, da ingestão de sal e de bebidas alcoólicas, do sedentarismo, do estresse emocional, e do uso do fumo. Na parte final, discute-se o papel de outros fatores dietéticos, (das terapias combinadas e, particularmente, como elas podem ser integradas em uma abordagem multidisciplinar do paciente hipertenso

Micropillar resonator in a magnetic field: Zero and Finite temperature cases

In this work, we present a theoretical study of a quantum dot-microcavity system which includes a constant magnetic field in the growth direction of the micropillar. First, we study the zero temperature case by means of a selfconsistent procedure with a trial function composed by a coherent photon field and a BCS function for the electron-hole pairs. The dependence of the ground-state energy on the magnetic field and the number of polaritons is found. We show that the magnetic field can be used as a control parameter of the photon number, and we make explicit the scaling of the total energy with the number of polaritons. Next, we study this problem at finite temperatures and obtain the scaling of the critical temperature with the number of polaritons.Comment: "Paper presented in PLMCN7. To appear in Superlattices and Microstructures

Physiological stress in eastern black rhinoceros (Diceros bicornis michaeli) as influenced by their density, climatological variables and sexes

It is important to understand the physiological stressors in animals especially for threatened species or intensively managed to improve their conservation and optimise their reproduction. We sought to understand changes in stress hormones (faecal glucocorticoid metabolites) in black rhinoceros (Diceros bicornis michaeli) in relation to population density and sex (intrinsic factors) and plant minerals, rainfall and land surface temperature (extrinsic factors). We used non-invasive faecal sampling techniques on animals of known sex, age and dominance in seven populations of contrasting population densities over 1 year. We measured variability in faecal corticosterone metabolites through radioimmunoassay and related them to population density, sex and faecal calcium, phosphorus, copper, zinc and potassium as characteristic of plant minerals, rainfall and temperature. We used linear mixed models (LMM) to analyse the data. We did not detect a significant relationship between physiological stress parameters and population density. However, we have indications that stress levels increased as rainfall and temperature increased and were correlated negatively and positively with concentration of faecal phosphorus and copper respectively; we found higher stress levels in females than in males. These results suggest that both intrinsic and extrinsic factors explain the variation in physiological stress observed in black rhinoceros

Isolation of vascular smooth muscle cells from a single murine aorta

The vascular smooth muscle cell plays a significant role in many important cardiovascular disorders, and smooth muscle biology is therefore important to cardiovascular research. The mouse is critical to basic cardiovascular research, largely because techniques for genetic manipulation are more fully developed in the mouse than in any othermammalian species. We describe here a technique for isolating smooth muscle cells from a single mouse aorta. This technique is particularly useful when material is limiting, as is frequently the case when genetically modified animals are being characterized.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43238/1/11022_2004_Article_381000.pd

Genomic Counter-Stress Changes Induced by the Relaxation Response

Background: Mind-body practices that elicit the relaxation response (RR) have been used worldwide for millennia to prevent and treat disease. The RR is characterized by decreased oxygen consumption, increased exhaled nitric oxide, and reduced psychological distress. It is believed to be the counterpart of the stress response that exhibits a distinct pattern of physiology and transcriptional profile. We hypothesized that RR elicitation results in characteristic gene expression changes that can be used to measure physiological responses elicited by the RR in an unbiased fashion. Methods/Principal Findings: We assessed whole blood transcriptional profiles in 19 healthy, long-term practitioners of daily RR practice (group M), 19 healthy controls (group $N_1$), and 20 $N_1$ individuals who completed 8 weeks of RR training (group $N_2$). 2209 genes were differentially expressed in group M relative to group $N_1$ (p<0.05) and 1561 genes in group $N_2$ compared to group $N_1$ (p<0.05). Importantly, 433 (p<$10_{−10}$) of 2209 and 1561 differentially expressed genes were shared among long-term (M) and short-term practitioners ($N_2$). Gene ontology and gene set enrichment analyses revealed significant alterations in cellular metabolism, oxidative phosphorylation, generation of reactive oxygen species and response to oxidative stress in long-term and short-term practitioners of daily RR practice that may counteract cellular damage related to chronic psychological stress. A significant number of genes and pathways were confirmed in an independent validation set containing 5 $N_1$ controls, 5 $N_2$ short-term and 6 M long-term practitioners. Conclusions/Significance: This study provides the first compelling evidence that the RR elicits specific gene expression changes in short-term and long-term practitioners. Our results suggest consistent and constitutive changes in gene expression resulting from RR may relate to long term physiological effects. Our study may stimulate new investigations into applying transcriptional profiling for accurately measuring RR and stress related responses in multiple disease settings

Effectiveness of the Relaxation Response-Based Group Intervention for Treating Depressed Chinese American Immigrants: A Pilot Study

Background:: This study examined the feasibility, safety and efficacy of an 8-week Relaxation Response (RR)-based group. Methods:: Twenty-two depressed Chinese American immigrants were recruited. Outcomes measures were response and remission rates, the Hamilton Rating Scale for Depression, Clinical Global Impressions Scale, Quality of Life Enjoyment and Satisfaction Questionnaire, and the Multidimensional Scale of Perceived Social Support Scale. Results: Participants (N = 22) were 82% female, mean age was 53 (±12). After intervention, completers (N = 15) showed a 40% response rate and a 27% remission rate, and statistically significant improvement in most outcome measures. Discussion: The RR-based group is feasible and safe in treating Chinese American immigrants with depression

Relaxation Response Induces Temporal Transcriptome Changes in Energy Metabolism, Insulin Secretion and Inflammatory Pathways

The relaxation response (RR) is the counterpart of the stress response. Millennia-old practices evoking the RR include meditation, yoga and repetitive prayer. Although RR elicitation is an effective therapeutic intervention that counteracts the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and aging, the underlying molecular mechanisms that explain these clinical benefits remain undetermined. To assess rapid time-dependent (temporal) genomic changes during one session of RR practice among healthy practitioners with years of RR practice and also in novices before and after 8 weeks of RR training, we measured the transcriptome in peripheral blood prior to, immediately after, and 15 minutes after listening to an RR-eliciting or a health education CD. Both short-term and long-term practitioners evoked significant temporal gene expression changes with greater significance in the latter as compared to novices. RR practice enhanced expression of genes associated with energy metabolism, mitochondrial function, insulin secretion and telomere maintenance, and reduced expression of genes linked to inflammatory response and stress-related pathways. Interactive network analyses of RR-affected pathways identified mitochondrial ATP synthase and insulin (INS) as top upregulated critical molecules (focus hubs) and NF-κB pathway genes as top downregulated focus hubs. Our results for the first time indicate that RR elicitation, particularly after long-term practice, may evoke its downstream health benefits by improving mitochondrial energy production and utilization and thus promoting mitochondrial resiliency through upregulation of ATPase and insulin function. Mitochondrial resiliency might also be promoted by RR-induced downregulation of NF-κB-associated upstream and downstream targets that mitigates stress

Correction: Genomic Counter-Stress Changes Induced by the Relaxation Response

The Competing Interests statement is incorrect. The correct Competing Interests statement is: The following authors hold or have held positions at the Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, which is paid by patients and their insurers for running the SMART-3RP and related relaxation/mindfulness clinical programs, markets related products such as books, DVDs, CDs and the like, and holds a patent pending (PCT/ US2012/049539 filed August 3, 2012) entitled Quantitative Genomics of the Relaxation Response : JAD, ALW, HB

Correction: Genomic Counter-Stress Changes Induced by the Relaxation Response

The Competing Interests statement is incorrect. The correct Competing Interests statement is: The following authors hold or have held positions at the Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hospital, which is paid by patients and their insurers for running the SMART-3RP and related relaxation/mindfulness clinical programs, markets related products such as books, DVDs, CDs and the like, and holds a patent pending (PCT/ US2012/049539 filed August 3, 2012) entitled Quantitative Genomics of the Relaxation Response : JAD, ALW, HB