The eclipsing bursting X-ray binary EXO 0748-676 revisited by XMM-Newton

The bright eclipsing and bursting low-mass X-ray binary EXO 0748-676 has been observed at several occasions by XMM-Newton during the initial calibration and performance verification (CAL/PV) phase. We present here the results obtained from observations with the EPIC cameras. Apart from several type-I X-ray bursts, the source shows a high degree of variability with the presence of soft flares. The wide energy coverage and high sensitivity of XMM-Newton allows for the first time a detailed description of the spectral variability. The source is found to be the superposition of a central (~2 10^8 cm) Comptonized emission, most probably a corona surrounding the inner edge of an accretion disk, associated with a more extended (~3 10^10 cm) thermal halo at a typical temperature of ~0.6 keV with an indication of non-solar abundances. Most of the variations of the source can be accounted for by a variable absorption affecting only the central comptonized component and reaching up to NH ~1.3 10^23 cm^{-2}. The characteristics of the surrounding halo are found compatible with an irradiated atmosphere of an accretion disc which intercepts the central emission due to the system high inclination.Comment: 6 pages, 4 figures, accepted for publication in A&A Letters, XMM special issu

XMM-Newton EPIC Observation of SMC SNR 0102-72.3

Results from observations of the young oxygen-rich supernova remnant SNR 0102-72.3 in the Small Magellanic Cloud during the calibration phase of the XMM-Newton Observatory are presented. Both EPIC-PN and MOS observations show a ringlike structure with a radius of ~15'' already known from Einstein, ROSAT and Chandra observations. Spectra of the entire SNR as well as parts in the eastern half were analyzed confirming shocked hot plasma in non-uniform ionization stages as the origin of the X-ray emission. The spectra differ in the northeastern and the southeastern part of the X-ray ring, showing emission line features of different strength. The temperature in the northeastern part is significantly higher than in the southeast, reflected by the lines of higher ionization stages and the harder continuum. Comparison to radio data shows the forward shock of the blast wave dominating in the northern part of the SNR, while the southern emission is most likely produced by the recently formed reverse shock in the ejecta. In the case of the overall spectrum of SNR 0102-72.3, the two-temperature non-equilibrium ionization model is more consistent with the data in comparison to the single plane-parallel shock model. The structure of SNR 0102-72.3 is complex due to variations in shock propagation leading to spatially differing X-ray spectra

Correcting density-driven errors in projection-based embedding

Projection-based embedding provides a simple and numerically robust framework for multiscale wavefunction-in-density-functional-theory (WF-in-DFT) calculations. The approach works well when the approximate DFT is sufficiently accurate to describe the energetics of the low-level subsystem and the coupling between subsystems. It is also necessary that the low-level DFT produces a qualitatively reasonable description of the total density, and in this work, we study model systems where delocalization error prevents this from being the case. We find substantial errors in embedding calculations on open-shell doublet systems in which self-interaction errors cause spurious delocalization of the singly occupied orbital. We propose a solution to this error by evaluating the DFT energy using a more accurate self-consistent density, such as that of Hartree-Fock (HF) theory. These so-called WF-in-(HF-DFT) calculations show excellent convergence towards full-system wavefunction calculations

Gendered nationalism : the gender gap in support for the Scottish National Party

Recent major surveys of the Scottish electorate and of Scottish National Party (SNP) members have revealed a distinct gender gap in support for the party. Men are markedly more likely than women to vote for the SNP and they comprise more than two-thirds of its membership. In this article, we use data from those surveys to test various possible explanations for the disproportionately male support for the SNP. While popular accounts have focused on the gendered appeal of recent leaders and on the party’s fluctuating efforts at achieving gender equality in its parliamentary representation, we find much stronger support for a different explanation. Women are less inclined to support and to join the SNP because they are markedly less supportive of its central objective of independence for Scotland. Since men and women barely differ in their reported national identities, the origins of this gender gap in support for independence presents a puzzle for further research

Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

Purpose: In June 2013 a European Medicines Agency referral procedure concluded that diclofenac was associated with an elevated risk of acute cardiovascular events and contraindications, warnings, and changes to the product information were implemented across the European Union. This study measured the impact of the regulatory action on the prescribing of systemic diclofenac in Denmark, The Netherlands, England, and Scotland. Methods: Quarterly time series analyses measuring diclofenac prescription initiation, discontinuation and switching to other systemic nonsteroidal anti-inflammatory (NSAIDs), topical NSAIDs, paracetamol, opioids, and other chronic pain medication in those who discontinued diclofenac. Absolute effects were estimated using interrupted time series regression. Results: Overall, diclofenac prescription initiations fell during the observation periods of all countries. Compared with Denmark where there appeared to be amore limited effect, the regulatory action was associated with significant immediate reductions in diclofenac initiation in The Netherlands (−0.42%, 95% CI, −0.66% to −0.18%), England (−0.09%, 95% CI, −0.11% to −0.08%), and Scotland (−0.67%, 95% CI, −0.79% to −0.55%); and falling trends in diclofenac initiation in the Netherlands (−0.03%, 95% CI, −0.06% to −0.01% per quarter) and Scotland (−0.04%, 95% CI, −0.05% to −0.02% per quarter). There was no significant impact on diclofenac discontinuation in any country. The regulatory action was associated with modest differences in switching to other pain medicines following diclofenac discontinuation. Conclusions: The regulatory action was associated with significant reductions in overall diclofenac initiation which varied by country and type of exposure. There was no impact on discontinuation and variable impact on switching

Ongoing initiatives within the Scottish National Health Service to affect the prescribing of selective serotonin reuptake inhibitors and their influence

Aim: Increasing use of selective serotonin-reuptake inhibitors (SSRIs) in Scotland, coupled with safety concerns with some SSRIs, and the increasing availability of generic SSRIs, have resulted in multiple initiatives to improve the quality and efficiency of their prescribing in Scotland. Our aim is to assess their influence to provide future direction. Materials & methods: The prescription costs analysis database was used to document utilization and expenditure on SSRIs between 2001 and 2017 alongside documenting the initiatives. Results: Multiple interventions over the years increased international nonproprietary name prescribing up to 99.9% lowering overall costs. This, coupled with initiatives to limit escitalopram prescribing due to concerns with its value, resulted in a 73.7% reduction in SSRI expenditure between 2001 and 2017 despite a 2.34-fold increase in utilization. Safety warnings resulted in a significant reduction in the prescribing of paroxetine, citalopram and escitalopram alongside a significant increase in sertraline Conclusion: Multiple initiatives have increased the quality and efficiency of SSRI prescribing in Scotland providing direction to others