Review of the New Communities Program: Toward Effective Implementation of Neighborhood Plans

Evaluates the progress of the New Communities Program, an initiative to revitalize sixteen Chicago neighborhoods, and recommends extending the MacArthur Foundation's financial support through another five-year grant

The display of spatial information and visually guided behavior

The basic informational elements of spatial orientation are attitude and position within a coordinate system. The problem that faces aeronautical designers is that a pilot must deal with several coordinate systems, sometimes simultaneously. The display must depict unambiguously not only position and attitude, but also designate the relevant coordinate system. If this is not done accurately, spatial disorientation can occur. The different coordinate systems used in aeronautical tasks and the problems that occur in the display of spatial information are explained

Lens ER-stress response during cataract development in Mip-mutant mice

AbstractMajor intrinsic protein (MIP) is a functional water-channel (AQP0) that also plays a key role in establishing lens fiber cell architecture. Genetic variants of MIP have been associated with inherited and age-related forms of cataract; however, the underlying pathogenic mechanisms are unclear. Here we have used lens transcriptome profiling by microarray-hybridization and qPCR to identify pathogenic changes during cataract development in Mip-mutant (Lop/+) mice. In postnatal Lop/+ lenses (P7) 99 genes were up-regulated and 75 were down-regulated (>2-fold, p=<0.05) when compared with wild-type. A pathway analysis of up-regulated genes in the Lop/+ lens (P7) was consistent with endoplasmic reticulum (ER)-stress and activation of the unfolded protein response (UPR). The most up-regulated UPR genes (>4-fold) in the Lop/+ lens included Chac1>Ddit3>Atf3>Trib3>Xbp1 and the most down-regulated genes (>5-fold) included two anti-oxidant genes, Hspb1 and Hmox1. Lop/+ lenses were further characterized by abundant TUNEL-positive nuclei within central degenerating fiber cells, glutathione depletion, free-radical overproduction, and calpain hyper-activation. These data suggest that Lop/+ lenses undergo proteotoxic ER-stress induced cell-death resulting from prolonged activation of the Eif2ak3/Perk-Atf4-Ddit3-Chac1 branch of the UPR coupled with severe oxidative-stress

Introducing a device to assist in the application of anti-embolism stockings

Using a device to help with the application and removal of anti-embolism stockings, often called thromboembolic deterrent stockings (TEDS), can potentially facilitate greater adherence to the use of stockings, and potentially reduce the risk of deep-vein thrombosis (DVT). This article describes a quality improvement project which used the Plan, Do, Study, Act (PDSA) cycle to facilitate the introduction of a device to aid in the application of thromboembolic deterrent stockings in an orthopaedic ward. The project findings showed that Neo-slip, a product designed to facilitate the use of compression stockings, can be effectively introduced into an orthopaedic ward, with positive feedback from both staff and patients

Economic analysis of the cost of inconsistencies in the implementation of ISDN network layer standards

Case studies depicting ISDN network layer interoperability and standards nonconformance were evaluated, and categorized by type. In each case study the root cause of the interoperability problem was identified, and validated with reference to the applicable ISDN standard. Corrective measures were proposed, and where implemented, the results of the correction were documented. Relative costs associated with the interoperability issue were identified, and recommendation\u27s outlining the best method for avoiding these inconsistencies going forward were presented

Germ-line and somatic EPHA2 coding variants in lens aging and cataract

Rare germ-line mutations in the coding regions of the human EPHA2 gene (EPHA2) have been associated with inherited forms of pediatric cataract, whereas, frequent, non-coding, single nucleotide variants (SNVs) have been associated with age-related cataract. Here we sought to determine if germ-line EPHA2 coding SNVs were associated with age-related cataract in a case-control DNA panel (> 50 years) and if somatic EPHA2 coding SNVs were associated with lens aging and/or cataract in a post-mortem lens DNA panel (> 48 years). Micro-fluidic PCR amplification followed by targeted amplicon (exon) next-generation (deep) sequencing of EPHA2 (17-exons) afforded high read-depth coverage (1000x) for > 82% of reads in the cataract case-control panel (161 cases, 64 controls) and > 70% of reads in the post-mortem lens panel (35 clear lens pairs, 22 cataract lens pairs). Novel and reference (known) missense SNVs in EPHA2 that were predicted in silico to be functionally damaging were found in both cases and controls from the age-related cataract panel at variant allele frequencies (VAFs) consistent with germ-line transmission (VAF > 20%). Similarly, both novel and reference missense SNVs in EPHA2 were found in the post-mortem lens panel at VAFs consistent with a somatic origin (VAF > 3%). The majority of SNVs found in the cataract case-control panel and post-mortem lens panel were transitions and many occurred at di-pyrimidine sites that are susceptible to ultraviolet (UV) radiation induced mutation. These data suggest that novel germ-line (blood) and somatic (lens) coding SNVs in EPHA2 that are predicted to be functionally deleterious occur in adults over 50 years of age. However, both types of EPHA2 coding variants were present at comparable levels in individuals with or without age-related cataract making simple genotype-phenotype correlations inconclusive

Banished from the Present: Musicians in Nazi Germany

This essay analyzes musical life in the Third Reich. More specifically, the focus will be on the Nazis’ regulation of music and the role that musicians themselves played in determining and enforcing cultural coordination. While some evidence extends into the war years (1939-1945), the bulk of the information presented here took place in the pre-war Nazi era (1933-1939). The purpose here is to show that those musicians who worked with and under the Nazis were affected in different ways and had varying levels of agency within the National Socialist system. Some have been branded collaborators, others victims, and this paper will question this binary system of classification. Following a trend of historical revisionism in this field, this paper takes into account that the question of culpability is now less certain than ever

The Paradox of Exclusive State-Court Jurisdiction over Federal Claims

Standing doctrine is supposed to ensure the separation of powers and an adversary process of adjudication. But recently, it has begun serving a new and unintended purpose: transferring federal claims from federal to state court. Paradoxically, current standing doctrine assigns a growing class of federal claims - despite Congressional intent to the contrary - to the exclusive jurisdiction of state courts. Even then, only in some states, and only to the extent authorized by state law.This paradox arises at the intersection of three distinct areas of doctrine:(1) a newly sharpened requirement of concrete injury under Article III that bars a wide swath of federal claims from being brought in federal court;(2) a general presumption that state courts can decide federal claims; and(3) the fact of our federalism that states are free to define the jurisdiction of their own courts, including by rejecting federal standing doctrine, as many states do.At the confluence of these factors lies the unintended consequence that standing doctrine is shifting claims arising under important swaths of the United States Code to the sole jurisdiction of state courts. This is perplexing because the literature teaches that federal courts have an essential role to play in the adjudication of federal claims, and Congress has assigned an ever-expanding set of federal claims to the original jurisdiction of federal courts. This paradox also threatens to undermine one of the key benefits of federal law itself - uniform, nationwide standards - by rendering federal law a patchwork quilt of enforceability, subject to the vagaries of state law. And it threatens to transform Article III’s limitation of the judicial power into a limitation on legislative power, committing a category error about the role that Article III plays in the structural constitutional order.Yet despite these grave costs, this paradox resists easy solutions. Each possible resolution bumps up against some important principle of our federal judicial system: legislative supremacy, the distinction between jurisdiction and merits, the limitation of the federal judiciary to deciding actual controversies, the distinct sovereignty of the states, and the supervisory power of the Supreme Court over questions of federal law. The paradox therefore highlights the unintended consequences and hidden trade-offs of novel jurisdictional limitations given the interlocking nature of our judicial federalism. Its resolution becomes a mirror into one’s commitments as between the values of federalism, separation of powers, and the purpose of federal law

Cumberland Congregational Church History and Vital Records 3rd Edition

https://digitalmaine.com/cumberland_books/1008/thumbnail.jp

Record of Persons Liable to Enrollment in the Militia of Maine, Town of Cumberland, 1881-1917

https://digitalmaine.com/cumberland_books/1068/thumbnail.jp