Global Civil Society and Health Advocacy in Intellectual Property Related Issues

Civil society organizations and other non-governmental organizations (NGOs) act as policy watchdogs and often represent the voices of marginalized populations. The importance of advocates in the field of Intellectual Property is apparent now more than ever. The global stage is changing; what were previously considered domestic issues have been thrust onto the international stage by agreements such as the Trade Related Aspects of Intellectual Property Rights agreement (TRIPS) (Sell & Prakash, 2004; Drahos & Braithwaite, 2001). The private sector has the resources to make their position heard; however, most other populations in society do not. Therefore, civil society and NGO groups are integral to advocating for health. The current trend of TRIPS+ style agreements which include much more stringent intellectual property rights (IPRs) laws, mean that the fight for access to medicines and medical technologies is intensifying.   This capstone uses a review of existing literature to explore the emerging concept of a global civil society, and the state of advocacy in Intellectual Property related issues. An interview with an advocate in the field helps inform how civil society organizations pursue their goals in the new IPR regime. The results of this capstone indicate that effective communications, strong relationships between organization and community, and an organizational emphasis on fostering individual work connections are integral to success

Residential Demand Side Management: Strategies for Increasing Electric Utility Profitability

Some electric utility leaders lack effective strategies to reduce demand billing charges. Utility leaders are concerned with lowering demand billing charges, as failure to do so can negatively affect profitability. Guided by the operations management theory, the purpose of this qualitative multiple case study was to explore strategies that distribution electric utility managers use to reduce demand billing chargers from their power providers. The participants were three electric utility leaders working in the Midwest United States who used successful residential demand-side management (DSM) strategies. Data were collected using semistructured interviews and utility documents to address the research question. The collected data were analyzed using Yin’s five-step data analysis, which included compiling, disassembling, reassembling, interpreting data, and concluding the findings. Three key themes emerged: residential demand billing is used to promote peak-shaving, education is used to make demand billing more acceptable to consumers, and incentive structures are tailored to ensure utility company costs are reduced or recouped. A key recommendation is for leaders of distribution electric utility companies to reduce demand billing charges from their power providers while making demand billing more acceptable to consumers and ensuring that utility company costs are reduced or recouped. The implications for positive social change include the potential to implement new strategies for improving DSM practices for benefiting residential applications. With the improvement of DSM, consumers\u27 total electric consumption can be decreased, which can increase disposable income for consumers

Consequences of <i>in vitro</i> benzyl butyl phthalate exposure for blubber gene expression and insulin-induced Akt activation in juvenile grey seals

Plastic and plasticiser pollution of marine environments is a growing concern. Although phthalates, one group of plasticisers, are rapidly metabolised by mammals, they are found ubiquitously in humans and have been linked with metabolic disorders and altered adipose function. Phthalates may also present a threat to marine mammals, which need to rapidly accumulate and mobilise their large fat depots. High molecular weight (HMW) phthalates may be most problematic because they can accumulate in adipose. We used blubber explants from juvenile grey seals to examine the effects of overnight exposure to the HMW, adipogenic phthalate, benzyl butyl phthalate (BBzP) on expression of key adipose-specific genes and on phosphorylation of Akt in response to insulin. We found substantial differences in transcript abundance of Pparγ, Insig2, Fasn, Scd, Adipoq and Lep between moult stages, when animals were also experiencing differing mass changes, and between tissue depths, which likely reflect differences in blubber function. Akt abundance was higher in inner compared to outer blubber, consistent with greater metabolic activity in adipose closer to muscle than skin, and its phosphorylation was stimulated by insulin. Transcript abundance of Pparγ and Fasn (and Adipoq in some animals) were increased by short term (30 min) insulin exposure. In addition, overnight in vitro BBzP exposure altered insulin-induced changes in Pparγ (and Adipoq in some animals) transcript abundance, in a tissue depth and moult stage-specific manner. Basal or insulin-induced Akt phosphorylation was not changed. BBzP thus acted rapidly on the transcript abundance of key adipose genes in an Akt-independent manner. Our data suggest phthalate exposure could alter seal blubber development or function, although the whole animal consequences of these changes are not yet understood. Knowledge of typical phthalate exposures and toxicokinetics would help to contextualise these findings in terms of phthalate-induced metabolic disruption risk and consequences for marine mammal health

A Better Life: Factors that Help and Hinder Entry and Retention in MAT from the Perspective of People in Recovery

Introduction: Opioid addiction and opioid-related overdoses and deaths are serious public health problems nationally and in West Virginia, in particular. Medication-assisted treatment (MAT) is an effective yet underutilized treatment for opioid use disorder (OUD). Purpose: Research examining factors that help individuals succeed in MAT has been conducted from provider and program perspectives, but little research has been conducted from the perspective of those in recovery. Methods: This study, co-developed with individuals in recovery, took place in West Virginia-based MAT programs using an exploratory sequential mixed methods approach. The survey was open February through August 2021. Data were analyzed late 2021 through mid 2022. Results: Respondents experienced many barriers to MAT entry and retention, including community bias / stigma, lack of affordable programming, and lack of transportation. Respondents sought MAT primarily for personal reasons, such as being tired of being sick, and tired of having to look for drugs every day. As one respondent shared, “I wanted to better my life, to get it under control.” Implications: Programs and policies should make it easy for individuals to enter treatment when ready, through affordable and accessible treatment options, reduced barriers to medications, focused outreach and education, individualized care, and reduced stigmatization

The Role of Discrete Emotions in Job Satisfaction: A Meta-Analysis

[Summary] The relationship between emotions and job satisfaction is widely acknowledged via affective events theory (AET). Despite its widespread use, AET was not designed to address why specific emotions might differentially relate to job satisfaction. We utilize appraisal theory of emotion to refine AET and provide this nuanced theorizing. We meta‐analytically test our ideas with 235 samples across 99 883 individuals and 22 600 intra‐individual episodes. We test two approaches—specific emotion experiences (16 discrete emotions) versus general emotion experiences (positive or negative emotions)—and present empirical evidence of their similarities and differences with job satisfaction. Our findings suggest that specific emotions with circumstance‐agency appraisals (e.g., depression and happiness) have the strongest associations with job satisfaction compared to emotions with self‐ and other‐agency appraisals and general emotion experiences. However, more variability is observed for negative emotions and job satisfaction compared to positive emotions. Further, we address and even challenge influential critiques of emotions and job satisfaction via a meta‐analytic test of five moderators—emotion intensity versus frequency, target of emotion, job satisfaction measure, level of analysis, and time referent for emotion and job satisfaction recall. In sum, we advance academic and practitioner understanding of the relationship between emotions and job satisfaction

Laser Microdissection of the Alveolar Duct Enables Single-Cell Genomic Analysis

Complex tissues such as the lung are composed of structural hierarchies such as alveoli, alveolar ducts, and lobules. Some structural units, such as the alveolar duct, appear to participate in tissue repair as well as the development of bronchioalveolar carcinoma. Here, we demonstrate an approach to conduct laser microdissection of the lung alveolar duct for single-cell PCR analysis. Our approach involved three steps. (1) The initial preparation used mechanical sectioning of the lung tissue with sufficient thickness to encompass the structure of interest. In the case of the alveolar duct, the precision-cut lung slices were 200 μm thick; the slices were processed using near-physiologic conditions to preserve the state of viable cells. (2) The lung slices were examined by transmission light microscopy to target the alveolar duct. The air-filled lung was sufficiently accessible by light microscopy that counterstains or fluorescent labels were unnecessary to identify the alveolar duct. (3) The enzymatic and microfluidic isolation of single cells allowed for the harvest of as few as several thousand cells for PCR analysis. Microfluidics based arrays were used to measure the expression of selected marker genes in individual cells to characterize different cell populations. Preliminary work suggests the unique value of this approach to understand the intra- and intercellular interactions within the regenerating alveolar duct