QUEL IMPACT DE L’HUILE D’ARGAN SUR LE CANCER DE LA PROSTATE ?

L’alimentation fgure parmi les facteurs environnementaux susceptibles de jouer un rôle important dans le développement ou la diminution du risque des cancers. En effet, de nombreuses études ont montré que trois types de cancers (sein, prostate et digestif) peuvent être fortement infuencés par l’alimentation notamment l’apport en lipides et en antioxydants.Dans ce contexte, notre travail s’inscrit dans le cadre d’une valorisation d’une huile alimentaire endémique du sud-ouest marocain : huile d’argan. En effet, l’huile d’argan est composée d’une part d’une fraction glycérique (99%) riche en acides gras insaturés et d’autre part d’une fraction insaponifable (1%) constituée d’hydrocarbures, de carotènes, de tocophérols, de stérols et de polyphénols. L’objectif de notre travail a été de rechercher l’activité antiproliférative de certaines molécules de la fraction insaponifable de l’huile d’argan et des saponines du tourteau sur trois lignées de cellules épithéliales de prostate humaines (LNCaP, DU145 et PC3). Nos résultats montrent que les polyphénols, stérols et tocophérols de l’huile d’argan ainsi que les saponines du tourteau exercent un effet anti-prolifératif et pro-apoptotique dose-dépendant sur les différentes lignées cellulaires testées. En conclusion, l’huile d’argan, grâce à sa teneur en polyphénols, en stérols, en tocophérols et aussi grâce aux saponines du tourteau, pourrait contribuer à la prévention du cancer de la prostate

Variability of a portion of RNA 3 containing the coat protein gene of Citrus variegation virus (CVV) using single-strand conformation polymorphism (SSCP)

A portion of RNA 3 of Citrus variegation virus (CVV), comprising part of the intergenic region and the coat protein (CP) gene from eight viral isolates, was amplified by RT-PCR and cloned. The clones were compared for intra and inter-isolate variations by single-strand conformation polymorphism analysis. Some of the results were compared with sequence data previously obtained. The test discriminated between clones differing in as little as 3.2% of the nucleotides. Most isolates included several variants, in some cases with a predominant pattern, which, however, could no longer be recognised in new RT-PCR products obtained 13 months later. This procedure can there-fore be used to identify and detect variations between CVV isolates. It is rapid, inexpensive and may reduce the amount of sequencing needed for comparing viral isolates

Uncommon Cause of Acute Pelvic Pain: Isolated Torsion of Hydrosalpinx

Isolated torsion of hydrosalpinx is a rare cause of acute pelvic pain. Pre-operative diagnosis is very difficult because of non specific clinical presentation. Definitive diagnosis is always made at surgicalexploration performed for suspected adnexal torsion and salpingectomy is performed in the majority of cases. A 34-year-old woman was admitted for acute pelvic pain with nausea and vomiting. Vaginal examination revealed a right adnexal tender mass and ultrasound revealed a well circumscribed right adnexal cystic mass. Surgical exploration has revealed torsion of a right hydrosalpinx and right salpingectomy was performed. Differential diagnosis between adnexal and tubal torsion is very difficult, however both should be managed by rapid surgical exploration which an allow precocious diagnosis and conservative treatment(Afr J Reprod Health 2009; 13[4]:147-150)

Synthesis analysis of the free form curves and surfaces parametrical models

Parametrical models have become an important mathematical tool for free form curves and surface description. they allow the use of state-of-the-art computers to do the various processing and analysis with respect to shape (calculation of the volume and surface area, vibration analysis, NC programs preparation, etc.). Without these models, the current product design and manufacturing would be difficult. The paper presents an analysis study for the most important parametrical models of free form curves and surfaces description (Ferguson, Coons, Bezier, B-Spline and rational models). Firstly, it emphasises external and mathematical properties of each model. Secondly, it gives the most interesting interfaces between models. Thus the process of complex surface design and manufacturing would be more efficient in view this analysis. Finally for validation, the study is ended by an application to the design of a car bonnet.Parametrical models have become an important mathematical tool for free form curves and surface description. they allow the use of state-of-the-art computers to do the various processing and analysis with respect to shape (calculation of the volume and surface area, vibration analysis, NC programs preparation, etc.). Without these models, the current product design and manufacturing would be difficult. The paper presents an analysis study for the most important parametrical models of free form curves and surfaces description (Ferguson, Coons, Bezier, B-Spline and rational models). Firstly, it emphasises external and mathematical properties of each model. Secondly, it gives the most interesting interfaces between models. Thus the process of complex surface design and manufacturing would be more efficient in view this analysis. Finally for validation, the study is ended by an application to the design of a car bonnet

Shared detection of Porphyromonas gingivalis in cohabiting family members: a systematic review and meta-analysis

Introduction: Periodontitis is an inflammatory dysbiotic disease. Among putative dysbiosis causes, transmission of Porphyromonas gingivalis between individuals of the same family remains unclear. The aim of this systematic review and meta-analysis is to assess the likelihood of shared detection of Porphyromonas gingivalis among cohabiting family members. Methods: A literature search?was conducted on different databases up to September 2018. Articles assessing the presence of P.gingivalis between members of the same family were screened. Only English literature was retrieved, whereas no limits were applied for bacterial sampling and detection methods. Results: Overall, 26 articles published between 1993 and 2017 met the inclusion criteria. Of these, 18 articles were used for meta-analyses. Based on bacterial culture, the likelihood of an intra-familial transmission of P.gingivalis once a member of the family harbors the bacterium is estimated at 63.5% (n = 132 pairs of family members); this drops to 45% when pooling together culture and Polymerase-Chain-Reaction (n = 481 pairs), whereas it is estimated at 35.7% when genotyping is applied (n = 137 pairs). Conclusion: Pooled results suggest that the likelihood of detecting P.gingivalis within within family members is moderately frequent. Personalized periodontal screening and prevention may consider intra-familial co-occurrence of P.gingivalis as feasible

Les polymères conjugués : Matériaux de futur. Propriétés et applications

Le prix Nobel de chimie attribué en 2000 à A.J.Heeger, H.Shirakawa et A.G.Mac Diamid pour leur contribution à l’étude des polymères pi-conjugués et leurs applications en sciences des matériaux a montré l’intérêt que porte la communauté scientifique à cette famille spécifique de polymères. Dans ce papier, nous présentons des généralités et quelques applications industrielles de ces nouveaux matériaux. Ces applications couvrent des domaines variés comme le stockage d’énergie (batteries, piles), la protection antistatique et électromagnétique, les semi-conducteurs organiques et les capteurs électrochimiques