3,949 research outputs found
Recent advances/contributions in the SuzukiāMiyaura reaction
Since the original reports of Suzuki-Miyaura on the coupling of vinyl or aryl boronic
acids with vinyl or aryl halides a remarkable number of publications have either
developed or applied this methodology in both an academic and industrial setting.
This review covers recent developments in the area, focusing on new methodology,
mechanistic implications and applications in medicinal, process and materials
chemistry
Perpetual Care: A Sustainable Approach to Restoring the Lost Landscapes of America\u27s Rural Cemeteries
During the mid 19th century burial practices in America evolved drastically with the creation of āruralā cemeteries. These burial grounds became incredibly popular didactic landscapes that were physical manifestations of contemporary Victorian social forces. Many of these historic landscapes are in need of conservation and restoration in order to preserve what remains. This thesis project lays out the significance of these sites, and provides a guide to restoring the character defining features of these cemeteries
New systems for catalytic asymmetric epoxidation
This thesis describes the catalytic asymmetric epoxidation of olefins mediated by
oxaziridinium salts. The introduction highlights some of the most successful methods
for preparing chiral oxiranes and hints at the synthetic utility of this versatile
molecule.
The second chapter is dedicated to our efforts to synthesize chiral iminium salts as
catalysts for asymmetric epoxidation. The first part of this chapter describes previous
Page group findings and leads on to the current author's efforts in this area. Initial
results from modified amino acids, cyclo-condensed to form dihydroisoquinolinium
salts, showed that an aromatic unit at C4 of our catalysts was vital for asymmetric
induction. Following this, several catalysts substituted at the 4-position of the
aromatic functionality were tested, and found to be effective mediators for asymmetric
epoxidation. Triphenylethylene was epoxidized with up to 71% ee when using oxone
as the stochieometric oxidant. [Continues.
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Searches for new physics with boosted top quarks in the MadAnalysis 5 and Rivet frameworks
High-momentum top quarks are a natural physical system in collider
experiments for testing models of new physics, and jet substructure methods are
key both to exploiting their largest decay mode and to assuaging resolution
difficulties as the boosted system becomes increasingly collimated in the
detector. To be used in new-physics interpretation studies, it is crucial that
related methods get implemented in analysis frameworks allowing for the
reinterpretation of the results of the LHC such as MadAnalysis 5 and Rivet. We
describe the implementation of the HEPTopTagger algorithm in these two
frameworks, and we exemplify the usage of the resulting functionalities to
explore the sensitivity of boosted top reconstruction performance to new
physics contributions from the Standard Model Effective Field Theory. The
results of this study lead to important conclusions about the implicit
assumption of Standard-Model-like top-quark decays in associated collider
analyses, and for the prospects to constrain the Standard Model Effective Field
Theory via kinematic observables built from boosted semi-leptonic
events selected using HEPTopTagger.Comment: 26 pages, 5 figure
Thiadiazolidine 1-oxide systems for phosphine-free palladium-mediated catalysis
We herein report several highly active catalyst systems with thiadiazolidine 1-oxides as ligands for palladium in the MizorokiāHeck reaction. Excellent yields of stilbenes derived from aryl iodides and bromides have been achieved using as little as 0.00002 mol % catalyst. The ligand/palladium system can be stored as a stock solution open to air at room temperature with no observable loss of activity for a period of several months
Impaired myocardial relaxation with exercise determines peak aerobic exercise capacity in heart failure with preserved ejection fraction
Background
Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired exercise capacity due to shortness of breath and/or fatigue. Assessment of diastolic dysfunction at rest and with exercise may provide insight into the pathophysiology of exercise intolerance in HFpEF. Aims
To measure echocardio-Doppler-derived parameters of diastolic function as they relate to various indices of aerobic exercise capacity in HFpEF. Methods
We selected 16 subjects with clinically stable HFpEF, no evidence of volume overload, but impaired functional capacity by cardiopulmonary exercise testing [peak oxygen consumption (VO2)]. We measured the transmitral E and A flow velocities, E/A ratio, and E deceleration time (DT) and tissue Doppler Eā² velocity. We also indexed the Eā² to the DT, as additional measure of impaired relaxation (Eā²DT), and calculated the diastolic functional reserve index (DFRI), as the product of Eā² at rest and change in Eā² with exercise. Results
Eā² velocity, at rest and peak exercise, as well as the DFRI positively correlated with peak VO2, whereas DT, Eā²DT, and E/Eā² with exercise inversely correlated with peak VO2. Of note, the Eā²DT at rest also significantly predicted Eā² velocity at peak exercise (R = +0.81, P \u3c 0.001). Exercise Eā² was the only independent predictor of peak VO2 at multivariable analysis (R = +0.67, P = 0.005). Conclusions
The Eā² velocity at peak exercise is a strong and independent predictor of aerobic exercise capacity as measured by peak VO2 in patients with HFpEF, providing the link between abnormal myocardial relaxation with exercise and impaired aerobic exercise capacity in HFpEF
A catalytic, mild and efficient protocol for the C-3 aerial hydroxylation of oxindoles
A mild, high yielding approach to C-3 hydroxylated oxindoles using catalytic quantities of
tetrabutylammonium fluoride and air as the stoicheiometric oxidant is reported over a wide
range of substitution patterns
Plasmas for organic synthesis and chemical probes for plasma diagnostics
Although organic chemistry plays a critical role in many plasma applications, there is
room for further cross-fertilization between the two disciplines. Here we explore two
possible avenues: (1) plasma physics as a new tool for the organic chemist and (2)
organic compounds as diagnostics for the plasma physicist
Comparative study of chemical probes for ozone detection
Plasma composition is typically studied by absorption and emission spectroscopy, mass spectrometry and computational studies. While these techniques
provide valuable information about the chemical species in the gas phase, in many applications it is desirable to have a direct measurement of the dose of
chemical species delivered to a particular target. For this purpose, chemical probes are particularly interesting as they can provide an inexpensive means for
determining the dose of a particular compound.
A number of chemical probes have recently been used by the plasma community, particularly those working in plasma medicine and with plasmas interacting
with liquids. Generally, however, these probes were not initially intended for use in plasma environments and therefore, it is important to assess their
suitability and identify any selectivity issue that could affect the correct interpretation of the measurements. Here, we report on a comparative study of three
chemical probes aimed at the quantitative detection of ozone (Table 1): Indigo Carmine and two DCF-derived fluorescent probes
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