Linear relationship found by magnetic resonance imaging between cerebrospinal fluid volume and body weight in dogs

Despite numerous studies on cerebrospinal fluid (CSF) and its importance during hydrocephalus or myelography, no reliable values exist about its overall volume in dogs. In this study, our aim was to measure the intracranial (IC) volume of CSF in dogs and assess its possible relationship with body size and the symmetry of the lateral ventricles. We ran a 3D magnetic resonance imaging (MRI) sequence on the central nervous system of 12 healthy, male mongrel dogs between 3–5 years of age and 7.5–35.0 kg body weight. A validated semiautomatic segmentation protocol was implemented to segment the CSF and measure its volume. Values for the volume of the ventricular compartment were between 0.97 and 2.94 ml, with 62.1 ± 11.7% in the lateral ventricles, 17.6 ± 4.9% in the third ventricle, 4.9 ± 1.6% in the aqueductus mesencephali and 15.5 ± 6.6% in the fourth ventricle. In 11 cases a significant asymmetry was found between the lateral ventricles. The results suggest that it may be normal for a dog to have one of the lateral ventricles 1.5 times larger than the other. The correlation between body weight and CSF volume was linear, indicating that the current dosage protocols for myelography, based on a hypothetical proportional relationship with body weight, may have to be revised

A kutya agykamráinak 3D rekonstrukciója és térfogat mehatározása MRI felvételek alapján

A kutya agykamráiban levő agy-gerincvelői folyadék (Cerebrospinal Fluid; CSF) térfogatára máig nincs meghatározott középérték. A humán adatok alapját is post mortem végzett mérési eljárások képezik, amelyek igen nagy eltérést mutatnak a kevés számú in vivo mérési eredménytől. Mindkét medicinában a hydrocephalus korai diagnosztizálásához, valamint az állatorvosi gyakorlatban sűrűn használt myelographia területén is fontos lenne a CSF térfogatra egy megbízható középérték meghatározása, vagy egy olyan mérési, becslési mód, amely a mindennapi gyakorlatban is kivitelezhető, használható. Kutatásunkban 12 klinikailag tünetmentes, oltott, féregtelenített, hím ivarú, 3-5 év közötti kutya agykamráinak T2 súlyozású spin echo MRI vizsgálatát végeztük el, majd a kapott felvételek alapján a 3DSlicer program segítségével elvégeztük az agykamrák 3D-s rekonstrukcióját

Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection

Inflammation is a key factor in the development of atherosclerosis, a disease characterized by the buildup of plaque in the arteries. COVID-19 infection is known to cause systemic inflammation, but its impact on local plaque vulnerability is unclear. Our study aimed to investigate the impact of COVID-19 infection on coronary artery disease (CAD) in patients who underwent computed tomography angiography (CCTA) for chest pain in the early stages after infection, using an AI-powered solution called CaRi-Heart®. The study included 158 patients (mean age was 61.63 ± 10.14 years) with angina and low to intermediate clinical likelihood of CAD, with 75 having a previous COVID-19 infection and 83 without infection. The results showed that patients who had a previous COVID-19 infection had higher levels of pericoronary inflammation than those who did not have a COVID-19 infection, suggesting that COVID-19 may increase the risk of coronary plaque destabilization. This study highlights the potential long-term impact of COVID-19 on cardiovascular health, and the importance of monitoring and managing cardiovascular risk factors in patients recovering from COVID-19 infection. The AI-powered CaRi-Heart® technology may offer a non-invasive way to detect coronary artery inflammation and plaque instability in patients with COVID-19