[1-(4-Chloro-2-fluoro­phenyl­sulfonyl)­piperidin-4-yl]di­phenyl­methanol

In the title compound, C24H23ClFNO3S, the piperidine ring is in a chair conformation. The geometry around the S atom is distorted tetra­hedral. The dihedral angle between the least-squares plane, P1, defined by four C atoms of the piperidine ring, and the dihalo-substituted benzene ring is 49.80 (1)°. The dihedral angles between P1 and the two phenyl rings are 59.34 (1) and 73.81 (1)°. The two phenyl rings make a dihedral angle of 65.13 (14)°. The structure exhibits inter­molecular hydrogen bonds of the types O—H⋯O and C—H⋯O

1-Phenyl\-sulfonyl-1\it H-1,2,4-triazole

In the title compound, C\sb 8H\sb 7N\sb 3O\sb 2S, the dihedral angle between the 1,2,4-triazole ring and the phenyl ring is 82.17(14)\circ. The geometry around the S atom is distorted tetra\-hedral. The mol\-ecules are linked by inter\-molecular C—-H⋅sN and C—-H⋅sO hydrogen bonds

Synthesis and Crystal Structure of 1-Benzhydryl-4-Methane-Sulfonyl-Piperazine

The title compound, 1-benzhydryl-4-methanesulfonyl-piperazine, was synthesized by the nucleophilic substitution of 1-benzhydryl-piperazine with methyl sulfonyl chloride. The product obtained was characterized by spectroscopic techniques, and the structure was investigated by X-ray crystallography. The compound crystallizes in the monoclinic crystal class in the space group P21/c with cell parameters a = 9.5820(4) A○, b = 16.8150(12) A○, c = 13.5280(8) A○, β = 127.270(5)°, and V = 1734.5(2)A○ 3 for Z = 4. The structure reveals that the piperazine ring is in a chair conformation. There is a large discrepancy around the bond angles of the piperazine N atoms. The geometry around the S atom is distorted tetrahedral

Synthesis and in vitro antiproliferative activity of diphenyl(sulphonylpiperidin-4-yl)methanol derivatives

A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a--n) were synthesized and characterized by 1H NMR, LC/MS, FTIR, and elemental analyses. All the synthesized compounds were evaluated for cell proliferation by MTT assay. The antiproliferative effects of the synthesized compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines, namely HeLa cells, HT-29 cells, MCF-7 cells, and HepG-2 cells in comparing the positive and negative control. Among the synthesized compounds, (10b) and (10g) have been identified as potent antiproliferative agents

Antimicrobial properties of endophytic actinomycetes isolated from combretum latifolium blume, a medicinal shrub from Western Ghats of India

A novel 1-benzhydryl piperazine derivative 1-benzhydryl-4-(2-nitro-benzenesulfonyl)-piperazine was synthesized by the nucleophilic substitution of 1-benzhydryl piperazine with 2-nitro-benzenesulfonyl chloride. The product obtained was characterized spectroscopically and finally confirmed by X-ray diffraction study. The title compound, C23H23N3O4S crystallizes in the monoclinic space group C2/c with cell parameters a = 13.1120(9) Å, b = 21.4990(9) Å, c = 16.655(1) Å, β = 111.352(2)°, Z = 8, and V = 4372.7(4) Å. The structure reveals that the piperazine ring is in a chair conformation. The geometry around the S atom is distorted tetrahedral. There is a large discrepancy in the bond angles around the piperazine N atoms. The structure is stablized by C–H···O type intermolecular hydrogen bonding interactions

Synthesis, characterization, crystal and molecular structure analysis of a novel 1-benzhydryl piperazine derivative: 1-benzhydryl-4-(2-nitro-benzenesulfonyl)-piperazine

A novel 1-benzhydryl piperazine derivative 1-benzhydryl-4-(2-nitro-benzenesulfonyl)-piperazine was synthesized by the nucleophilic substitution of 1-benzhydryl piperazine with 2-nitro-benzenesulfonyl chloride. The product obtained was characterized spectroscopically and finally confirmed by X-ray diffraction study. The title compound, C23H23N3O4S crystallizes in the monoclinic space group C2/c with cell parameters a = 13.1120(9) Å, b = 21.4990(9) Å, c = 16.655(1) Å, β = 111.352(2)°, Z = 8, and V = 4372.7(4) Å. The structure reveals that the piperazine ring is in a chair conformation. The geometry around the S atom is distorted tetrahedral. There is a large discrepancy in the bond angles around the piperazine N atoms. The structure is stablized by C–H···O type intermolecular hydrogen bonding interactions

Synthesis and in vitro antiproliferative activity of diphenyl(piperidin-4- yl)thioamide methanol derivatives

A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-j) were synthesized and characterized by 1H NMR, LC/MS, FTIR and elemental analyses. All the compounds synthesised were evaluated for their cell antiproliferation activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The antiproliferative effects of the synthesised compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines namely HeLa, HT-29, MCF-7, HepG-2 by adopting positive and negative control. The importance of the methoxy and fluorine group on diphenyl(piperidin-4-yl)methanol moiety was confirmed and it was noted that, the substitution at 4th position of the aryl ring plays a dominant role and was responsible for the antiproliferative activity. Among the synthesized compounds, only (10a) and (10b) have potent antiproliferative activity on all the carcinoma cell lines tested

Structural conformation of a novel 1-benzhydrylpiperazine derivative: 1-benzhydryl-4-(toluene-4-sulfonyl)-piperazine

The title compound 1-benzhydryl-4-(toluene-4-sulfonyl)-piperazine was synthesized and the structure was investigated by X-ray crystallography. The title compound, C24H26N2O2S crystallizes in the monoclinic crystal class in the space group P2(1)/c with cell parameters a = 13.5800(10) angstrom, b = 8.9630(7) angstrom, c = 18.9040(10) angstrom, beta = 106.851(3)degrees, Z = 4 and V = 2202.1(3) angstrom(3). The structure has been solved by direct methods and refined to R-1 = 0.0468 for 3174 observed reflections I > 2 sigma(I). The structure reveals that the piperazine ring is in a chair conformation. The geometry around the S atom is a distorted tetrahedron