Special focus: metals in medicine

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The effect of cycling on cognitive function and well-being in older adults

It has been demonstrated that, on their own, both exercise and stimulation from the environment can improve cognitive function and well-being in older adults. The combined effect of exercising in the outdoor environment on psychological function is less well studied. The aim of the current study was to investigate the effect of an outdoor cycling intervention on cognitive function and mental health and well-being in older adults. A total of 100 older adults took part in the study (aged 50–83), 26 of which were non-cycling controls, 36 were conventional pedal cyclists and 38 were participants using an e-bike (a bike fitted with an electric motor to provide assistance with pedaling), as part of a larger project (www.cycleboom.org). Participants took part in the study for an eight-week period, with cycling participants required to cycle at least three times a week for thirty minutes in duration for each cycle ride. Cognitive function and well-being were measured before and after the intervention period. For executive function, namely inhibition (the Stroop task) and updating (Letter Updating Task), both cycling groups improved in accuracy after the intervention compared to non-cycling control participants. E-bike participants also improved in processing speed (reaction times in go trials of the Stop-It task) after the intervention compared to non-cycling control participants. Finally, e-bike participants improved in their mental health score after the intervention compared to non-cycling controls as measured by the SF-36. This suggests that there may be an impact of exercising in the environment on executive function and mental health. Importantly, we showed a similar (sometimes larger) effect for the e-bike group compared to the pedal cyclists. This suggests that it is not just the physical activity component of cycling that is having an influence. Both pedal cycles and e-bikes can enable increased physical activity and engagement with the outdoor environment with e-bikes potentially providing greater benefits

Co-Creation as an agonistic practice in the favela of Santa Marta, Rio de Janeiro

This paper explores the potential of ‘Co-Creation’ to develop new understandings of neighbourhood disadvantage in collaboration with civil society partners. It argues that there is a growing need for collaborative knowledge production with communities carrying vernacular knowledges previously invalidated by dominant epistemologies. The first part of the paper undertakes a reconceptualization of ‘co-creation’, a term usually associated with citizen involvement in neoliberal contexts, redeveloping it as a ‘critical artistic practice’ (Chantal Mouffe, 2013) in which new ways of imagining the city can be articulated. The second part of the paper examines the practice of Co-Creation as a participatory methodology involving artists, researchers and stakeholders in developing ‘agonistic spaces’ by scrutinizing a five-day workshop conducted in the Rio de Janeiro favela of Santa Marta to explore multiple understandings and meanings of this neighbourhood. Through an analysis of creative workshop activities such as photovoice and mapping exercises, the authors explore the potential of the Co-Creation approach to construct new subjectivities that can help subvert existing configurations of power. The conclusion formulates some recommendations about future strategies to maximise Co-Creation’s potential to engage communities in collaborative knowledge production about their neighbourhoods and bring about positive change.

Stationary Reflection and the failure of SCH

In this paper we prove that from large cardinals it is consistent that there is a singular strong limit cardinal $\nu$ such that the singular cardinal hypothesis fails at $\nu$ and every collection of fewer than $\mathrm{cf}(\nu)$ stationary subsets of $\nu^+$ reflects simultaneously. For uncountable cofinality, this situation was not previously known to be consistent. Using different methods, we reduce the upper bound on the consistency strength of this situation for $\mathrm{cf}(\nu) = \omega$ to below a single partially supercompact cardinal. The previous upper bound of infinitely many supercompact cardinals was due to Sharon.Comment: 23 page

Dynamics of salt marsh margins are related to their 3-dimensional

The three-dimensional configuration of sedimentary landforms in intertidal environments represents a major control on regional hydrodynamics. It modulates the location and magnitude of forces exerted by tidal currents and waves on the landform itself and on engineered infrastructure such as sea walls or coastal defences. Furthermore, the effect is reflexive with the landforms representing an integrated, long-term response to the forces exerted on them. There is a strong reciprocal linkage between form and process (morphodynamics) in the coastal zone which is significantly lagged and poorly understood in the case of cohesive, vegetated sediments in the intertidal zone. A method is presented that links the geometric properties of the tidal at-saltmarsh interface to the history and potential future evolution of that interface. A novel quantitative classification scheme that is capable of separating marsh margins based on their functional form is developed and is applied to demonstrate that relationships exist between landform configuration and morphological evolution across a regional extent. This provides evidence of a spatially variable balance between self-organised and external controls on morphodynamic evolution and the first quantitative basis for a quick assessment procedure for likely future dynamism.Foreshore Assessment using Space Technology (FAST) EU 7th Framework Programme FP7-SPACE-2013-1 The Isaac Newton Trust

Derivation of material properties using small punch and shear punch test methods

The Small Punch (SP) and Shear Punch (ShP) tests are well established mechanical test approaches that have found application in several industrial sectors for material ranking and mechanical property estimation, particularly where more conventional approaches are inhibited. Despite the advantages that the two test methodologies have to offer, the main drawback is the complex understanding of the mechanical data generated from the experiments and how it can be correlated to more recognised properties. Typically, the most desired properties relate to the uniaxial properties of yield stress, ultimate tensile strength and ductility, but to date, there is no single robust and overarching approach for correlating such properties for a wide array of metallic materials that exhibit varying levels of ductility. This paper will for the first time directly compare properties obtained from a series of uniaxial tensile, SP and ShP tests across several metallic materials, and look to establish and correlate equivalent properties across the different test types. The materials investigated range from commercially pure entities to more advanced alloy systems. The generated results, empirical relationships and numerical simulations will inform which materials can be correlated across the different test regimes, and identify why the relationship in certain materials breaks down

Revealing ensemble state transition patterns in multi-electrode neuronal recordings using hidden Markov models

In order to harness the computational capacity of dissociated cultured neuronal networks, it is necessary to understand neuronal dynamics and connectivity on a mesoscopic scale. To this end, this paper uncovers dynamic spatiotemporal patterns emerging from electrically stimulated neuronal cultures using hidden Markov models (HMMs) to characterize multi-channel spike trains as a progression of patterns of underlying states of neuronal activity. However, experimentation aimed at optimal choice of parameters for such models is essential and results are reported in detail. Results derived from ensemble neuronal data revealed highly repeatable patterns of state transitions in the order of milliseconds in response to probing stimuli