Kaposi’s Sarcoma Presenting As Lymphadenopathy In An Immunocompetent Patient

Introduction: Kaposi’s sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form, especially if it precedes the skin manifestations. We describe the case of an elderly HIV-negative patient presenting with lymphadenopathy who was found to have KS. Case Report: A 67-year-old patient was admitted for exploration of polyadenopathies in the context of a general decline in health. Physical examination revealed an erythematosus left lower limb rash associated with angiomatous nodules and multiple lymphadenopathies. The diagnosis of erysipelas in the left leg was retained and the patient was treated with good evolution of the rash but persistence of the angiomatous nodules and the polyadenopathies. Skin and lymph node biopsies led to a diagnosis of KS. The patient is proposed for polychemotherapy. Conclusion: KS must be suspected in lymphadenopathies despite the absence of typical cutaneous signs of the disease and in immunocompetent patients

Epidemiological, clinical, and therapeutic characteristics of Behçet's disease: a monocentric study in Tunisia

Introduction: to describe the epidemiological, clinical, therapeutic and evolving characteristics of Behçet´s disease and identify prognostic factors. Methods: we have realized a retrospective, single-center study, conducted over a period of 26 years and including 130 patients presenting Behçet´s disease and hospitalized in an Internal Medicine Department. Results: the mean age of the Behçet´s disease at onset was 30.3 ±8.8 years and that at diagnosis was 34.6 ±9.4 years. The sex ratio (male/female) was 2.5. The mean delay of diagnosis was 53.5 months. Oral aphthosis was constant. The frequency of the manifestations was: genital aphtosis 71.5%, pseudofolliculitis 84.6%, erythema nodosum 11.5%, positive pathergy test 50%, ocular disease 36.9%, venous thrombosis 30%, arterial disease 4.6%, joint damage 30.8%, neurological disease 19.2% and digestive disease 0.8%. The male gender was significantly associated with ocular involvement (p =0.02), venous disease (p =0.01) and occurrence of relapses (p =0.01). The mean follow up was 68.5 ± 77.3 months. The poor survival prognostic factors were male gender, ocular involvement, venous disease, cardiovascular disease, a duration of follow up ≤12 months and a diagnostic delay ≤ 24 months. Conclusion: improving the prognosis of Behçet´s disease requires a shortening of the time to diagnosis, multidisciplinary collaboration, intensive treatment of functional threats, regular monitoring, and patient adherence

Ectopic Axillary Breast during Systemic Lupus

Many breast changes may occur in systemic lupus erythematosus. We report a 41-year-old woman with lupus who presented three years after the onset of lupus an ectopic mammary gland confirmed by histological study

Psoriasis and connective tissue diseases: What about Sjogren syndrome?

Psoriasis (Ps) is an autoimmune chronic skin disease with a high prevalence in the general population. Connective tissue diseases (CTD) are also autoimmune disorders of unknown cause with highly variable clinical expression. The combination of CTD and psoriasis is uncommon and has rarely been described. We report two cases of CTD associated with psoriasis: a case of systemic lupus erythematosus (SLE) and a case of Sjogren syndrome (SS)s

Cutaneous vasculitis associated with Helicobacter pylori

Helicobacter pylori is a widely prevalent microbe, Epidemiological and experimental data pointed recently to a strong relation of H. pylori infection on the development of many extragastric diseases, including several allergic and autoimmune diseases. We report a 65-year-old man who presented with cutaneous vasculitis accompanied by gastric H. pylori (Hp) infection. The gastro intestinal manifestations and purpuric lesions were dramatically resolved after Hp eradication therapy

Bowen’s disease in a patient with Primary Sjögren’s syndrome: A case report and a review of the literature

A rare case of Bowen’s disease (BD) in a patient with Primary Sjögren’s syndrome is reported. A 42-year-old woman suffering from Primary Sjögren’s syndrome retained on the basis of clinical and serological findings, was admitted 3 years later for genital bleeding. The diagnosis of Bowen’s disease was established by clinical and histolopathological examination. Classical association of lymphoma and Sjögren’s syndrome is described, but to the best of our knowledge, it is the second report of BD associated to Sjögren’s syndrome in published literature. A common physio-pathological etiology cannot be excluded

Theoretical modelling of the ionospheric F1-ledge, part I: occurence and evolution

Submitted to Journal at Atmospheric and Terrestrial PhysicsConsiglio Nazionale delle Ricerche (CNR). Biblioteca Centrale / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

Lupus erythematosus panniculitis: A case report

Lupus erythematosus panniculitis (LEP), an uncommon variant in the clinicopathological spectrum of lupus erythematosus (LE), is rare. There are only a few reported series of patients with this condition; none in individuals of North African ancestry. LEP is characterized by inflammation of the deep dermis and subcutaneous tissue. It usually consists of nodules and hardened subcutaneous plaques on the forehead, cheeks, proximal extremities, and buttocks. Leg involvement is rare and can lead to misdiagnosis. A case of LEP, with unusual involvement of legs, is reported in a 40-year-old woman who had the diagnosis of systemic lupus erythematosus (SLE) four years ago

Epizootic haemorrhagic disease virus circulation in Tunisia

Epizootic haemorrhagic disease virus (EHDV) was detected for the first time in Tunisia and in other Northern African countries in 2006.The objective of the present study was to investigate whether EHDV circulated in Tunisian livestock beforeand after the officially-reported outbreak of 2006.Thus, serum samples from cattle and dromedaries collected in different time periods (before and after 2006) and from different regions of Tunisia were screened for the presence of EHDV antibodies. Serological investigations conducted on cattle and dromedary sera collected in 2000 and 2001 demonstrated no virus circulation on these dates. However, viral circulation was evidenced in 2012 and 2013, although no EHDV cases were officially reported in these years. Serum-neutralization assessed on few ELISA positive samples, confirmed the presence of antibodies against EHDV serotype 6, which was the serotype involved in the EHDV outbreak in the Maghreb region in 2006