Evaluación de diferentes alternativas de manejo de suelo durante el invierno y su impacto sobre malezas, contenido de agua, disponibilidad de nitrógeno y el rendimiento de maíz tardío (Zea mays, L.)

Teniendo en cuenta el proceso de agriculturización a lo largo de los años y la escaza intensificación de los sistemas, con períodos largos de barbecho, es necesario incorporar prácticas que permitan producir de manera sustentable y sostenible en el tiempo. Una opción para afrontar esta problemática es la incorporación de cultivos de cobertura (CC) durante el período invernal aprovechando sus beneficios y mejorando la eficiencia de los sistemas agrícolas actuales. El objetivo de este trabajo fue evaluar diferentes alternativas de manejo de suelo durante el invierno y su impacto sobre malezas, contenido de agua, disponibilidad de nitrógeno y el rendimiento de maíz tardío (Zea mays, L.). El experimento se realizó en la EEA INTA Manfredi. Los tratamientos evaluados fueron: Vicia vi/losa (V), V. vi/losa + triticale (V+T) y Barbecho (8). Luego de la siembra del maíz el ensayo se dividió en dos, ya que se realizó fertilización solo a la mitad del mismo, quedando establecidos dos niveles de nitrógeno (O y 99 kg N ha-1). El tratamiento V+T logró la mayor supresión de malezas en general. Vicia vi/losa permitió la implantación y crecimiento de malezas de ciclo otoño - invernal y tuvo una supresión parcial de las de ciclo primavera estival. Los CC redujeron el agua útil (AU) al momento del secado con respecto a B, sin embargo, estas diferencias se redujeron a la siembra de maíz, no habiendo diferencias en madurez fisiológica (MF) del cultivo. El rendimiento del maíz no presentó diferencias significativa entre los diferentes manejos invernales, tanto en maíz fertilizado como no fertilizado. Having into account the agriculturalitation process throughout the years and the scarce intensification of the systems with long periods of fallow, it is necessary to incorporate practices that allow us producing in a sustainable manner in time. An alternative to face up these difficulties is the incorporation of cover crops (CC) during the winter period, taking advantage of its benefits and improving the efficiency of the current agricultural systems. The purpose of this work was to evaluate different possibilities of soil management during winter and their impact on weeds, water content, nitrogen availability, and late corn productivity (Zea mays, L.). The experiment was carried out in EEA INTA Manfredi. The treatments assessed were: Vicia vi/losa (V), V. vi/losa + triticale (V+T) and Fallow (8). After the corn sowing, the trial was divided into two as the fertilization was made only in the half of it, therefore, two nitrogen levels were established (O y 99 kg N t,a-1 ). The treatment V+T reached the higher weed suppression in general. Vicia vi/llosa permitted the implantation and growth of weeds in the autumn-winter cycle, and it had a partial suppression from those in the summer- spring cycle. The CC reduced the useful water (AU) at the time of drying compared to B, however, these dissimilarities were reduced to the corn sowing so there were not differences in physiological maturity (MF) of the crop. The corn production did not present statistical changes among the various winter management, both in fertilizad corn and non-fertilized corn.-Fil: Álvarez, Carolina. Universidad Nacional de Villa María; Argentina.Fil: Ustarroz, Diego. Universidad Nacional de Villa María; Argentina.Fil: Cura, Luciana N. Universidad Nacional de Villa María; Argentina.Fil: Beltrami, Jennifer B. Universidad Nacional de Villa María; Argentina

Perturbation Theory for Metastable States of the Dirac Equation with Quadratic Vector Interaction

The spectral problem of the Dirac equation in an external quadratic vector potential is considered using the methods of the perturbation theory. The problem is singular and the perturbation series is asymptotic, so that the methods for dealing with divergent series must be used. Among these, the Distributional Borel Sum appears to be the most well suited tool to give answers and to describe the spectral properties of the system. A detailed investigation is made in one and in three space dimensions with a central potential. We present numerical results for the Dirac equation in one space dimension: these are obtained by determining the perturbation expansion and using the Pad\'e approximants for calculating the distributional Borel transform. A complete agreement is found with previous non-perturbative results obtained by the numerical solution of the singular boundary value problem and the determination of the density of the states from the continuous spectrum.Comment: 10 pages, 1 figur

A human neuronal model of Niemann Pick C disease developed from stem cells isolated from patient's skin.

Niemann Pick C (NPC) disease is a neurovisceral lysosomal storage disorder due to mutations in NPC1 or NPC2 genes, characterized by the accumulation of endocytosed unesterified cholesterol, gangliosides and other lipids within the lysosomes/late endosomes. Even if the neurodegeneration is the main feature of the disease, the analysis of the molecular pathways linking the lipid accumulation and cellular damage in the brain has been challenging due to the limited availability of human neuronal models.The aim of this study was to develop a human neuronal model of NPC disease by inducing neuronal differentiation of multipotent adult stem cells (MASC) isolated from NPC patients.Stem cells were isolated from 3 NPC patients and 3 controls both from skin biopsies and previously established skin fibroblast cultures. Cells were induced to differentiate along a neuronal fate adapting methods previously described by Beltrami et al, 2007. The surface immunophenotype of stem cells was analyzed by FACS. Stem cell and neuronal markers expression were evaluated by immunofluorescence. Intracellular accumulation of cholesterol and gangliosides were assessed by filipin staining and immunofluorescence, respectively. A morphometric analysis was performed using a Neurite outgrowth image program.After 3 passages in selective medium, MASC isolated either from skin biopsies or previously established skin fibroblast cultures displayed an antigenic pattern characteristic of mesenchymal stem cells and expressed the stem cell markers Oct-4, Nanog, Sox-2 and nestin. A massive lysosomal accumulation of cholesterol was observed only in cells isolated from NPC patients. After the induction of neural differentiation, remarkable morphologic changes were observed and cells became positive to markers of the neuronal lineage NeuN and MAP2. Differentiated cells from NPC patients displayed characteristic features of NPC disease, they showed intracellular accumulation of unesterified cholesterol and GM2 ganglioside and presented morphological differences with respect to cells derived from healthy donors.In conclusion, we generated a human neuronal model of NPC disease through the induction of differentiation of stem cells obtained from patient's easily accessible sources. The strategy described here may be applied to easily generate human neuronal models of other neurodegenerative diseases

Borehole climatology: a discussion based on contributions from climate modeling

Progress in understanding climate variability through the last millennium leans on simulation and reconstruction efforts. Exercises blending both approaches present a great potential for answering questions relevant both for the simulation and reconstruction of past climate, and depend on the specific peculiarities of proxies and methods involved in climate reconstructions, as well as on the realism and limitations of model simulations. This paper explores research specifically related to paleoclimate modeling and borehole climatology as a branch of climate reconstruction that has contributed significantly to our knowledge of the low frequency climate evolution during the last five centuries. The text flows around three main issues that group most of the interaction between model and geothermal efforts: the use of models as a validation tool for borehole climate reconstructions; comparison of geothermal information and model simulations as a means of either model validation or inference about past climate; and implications of the degree of realism on simulating subsurface climate on estimations of future climate change. The use of multi-centennial simulations as a surrogate reality for past climate suggests that within the simplified reality of climate models, methods and assumptions in borehole reconstructions deliver a consistent picture of past climate evolution at long time scales. Comparison of model simulations and borehole profiles indicate that borehole temperatures are responding to past external forcing and that more realism in the development of the soil model components in climate models is desirable. Such an improved degree of realism is important for the simulation of subsurface climate and air-ground interaction; results indicate it could also be crucial for simulating the adequate energy balance within climate change scenario experiments

Gradient catastrophe and flutter in vortex filament dynamics

Gradient catastrophe and flutter instability in the motion of vortex filament within the localized induction approximation are analyzed. It is shown that the origin if this phenomenon is in the gradient catastrophe for the dispersionless Da Rios system which describes motion of filament with slow varying curvature and torsion. Geometrically this catastrophe manifests as a rapid oscillation of a filament curve in a point that resembles the flutter of airfoils. Analytically it is the elliptic umbilic singularity in the terminology of the catastrophe theory. It is demonstrated that its double scaling regularization is governed by the Painlev\'e-I equation.Comment: 11 pages, 3 figures, typos corrected, references adde

ZZ--Z′Z' mixing and oblique corrections in an SU(3)×U(1){\rm SU(3) \times U(1)} model

A global fit for experiments is included in this revised version.Comment: IFP-460-UNC, TRI-PP-93-11, 20 pages, 2 figures are appende

Three Kinds of Special Relativity via Inverse Wick Rotation

Since the special relativity can be viewed as the physics in an inverse Wick rotation of 4-d Euclid space, which is at almost equal footing with the 4-d Riemann/Lobachevski space, there should be important physics in the inverse Wick rotation of 4-d Riemann/Lobachevski space. Thus, there are three kinds of special relativity in de Sitter/Minkowski/anti-de Sitter space at almost equal footing, respectively. There is an instanton tunnelling scenario in the Riemann-de Sitter case that may explain why \La be positive and link with the multiverse.Comment: 3 pages, no figures, to appear in Chin. Phys. Let

Classification of integrable Weingarten surfaces possessing an sl(2)-valued zero curvature representation

In this paper we classify Weingarten surfaces integrable in the sense of soliton theory. The criterion is that the associated Gauss equation possesses an sl(2)-valued zero curvature representation with a nonremovable parameter. Under certain restrictions on the jet order, the answer is given by a third order ordinary differential equation to govern the functional dependence of the principal curvatures. Employing the scaling and translation (offsetting) symmetry, we give a general solution of the governing equation in terms of elliptic integrals. We show that the instances when the elliptic integrals degenerate to elementary functions were known to nineteenth century geometers. Finally, we characterize the associated normal congruences

Systemic T Cells Immunosuppression of Glioma Stem Cell-Derived Exosomes Is Mediated by Monocytic Myeloid-Derived Suppressor Cells

A major contributing factor to glioma development and progression is its ability to evade the immune system. Nano-meter sized vesicles, exosomes, secreted by glioma-stem cells (GSC) can act as mediators of intercellular communication to promote tumor immune escape. Here, we investigated the immunomodulatory properties of GCS-derived exosomes on different peripheral immune cell populations. Healthy donor peripheral blood mononuclear cells (PBMCs) stimulated with anti-CD3, anti-CD28 and IL-2, were treated with GSC-derived exosomes. Phenotypic characterization, cell proliferation, Th1/Th2 cytokine secretion and intracellular cytokine production were analysed by distinguishing among effector T cells, regulatory T cells and monocytes. In unfractionated PBMCs, GSC-derived exosomes inhibited T cell activation (CD25 and CD69 expression), proliferation and Th1 cytokine production, and did not affect cell viability or regulatory T-cell suppression ability. Furthermore, exosomes were able to enhance proliferation of purified CD4+ T cells. In PBMCs culture, glioma-derived exosomes directly promoted IL-10 and arginase-1 production and downregulation of HLA-DR by unstimulated CD14+ monocytic cells, that displayed an immunophenotype resembling that of monocytic myeloid-derived suppressor cells (Mo-MDSCs). Importantly, the removal of CD14+ monocytic cell fraction from PBMCs restored T-cell proliferation. The same results were observed with exosomes purified from plasma of glioblastoma patients. Our results indicate that glioma-derived exosomes suppress T-cell immune response by acting on monocyte maturation rather than on direct interaction with T cells. Selective targeting of Mo-MDSC to treat glioma should be considered with regard to how immune cells allow the acquirement of effector functions and therefore counteracting tumor progression

On the Structure of the Magnetic Field in a Kinematic ABC Flow Dynamo

The kinematic induction equation of MHD is solved numerically in the case of the normal ``111'' ABC flow using a general staggered mesh method. Careful 3-D visualizations of the topology of the magnetic field reveal that previous conclusions about the modes of operation of this type of kinematic dynamo must be revised. The two known windows of dynamo action at low and high magnetic Reynolds number, correspond to two distinct modes, both relying crucially on the replenishing of the magnetic field near a discontinuity at the beta-type stagnation points in the flow. One of these modes display double magnetic structures that were previously found only to obscure the physics of the dynamo: They turn out, however, to play an important part in the process of amplifying the magnetic field. Invariant properties of the mode in the second magnetic Reynolds number window support the case for the normal ABC flow as a fast dynamo.Comment: Associated webpage, see http://www.astro.su.se/~dorch/dynamo