On the semiproportional character conjecture in groups Sp4(q)

Previously, the author made the following conjecture: if a finite group has two semiproportional irreducible characters φ and ψ, then φ(1) = ψ(1). In the present paper, a new confirmation of the conjecture is obtained. Namely, the conjecture is verified for symplectic groups Sp4(q) and PSp4(q). © 2013 Pleiades Publishing, Ltd

Photodynamic therapy at the treatment of recurrent basal cell skin cancer

The article reviews new laser-based methods of treatment of basal cell skin cancer. The results of the treatment of 25 patients with skin cancer were analyzed. The article reviews problems of complicated course of the disease when surgical and X-ray methods of treatment are not enough. We started to apply photodynamic therapy with use of Radahlorin for the enhancement of the results of treatment of recurrent basal cell skin cancer. New method of treatment became rather effective at the treatment of recurrent basal cell skin cancer

Katanin catalyzes microtubule depolymerization independently of tubulin C-terminal tails

Microtubule network remodeling is an essential process for cell development, maintenance, cell division, and motility. Microtubule‐severing enzymes are key players in the remodeling of the microtubule network; however, there are still open questions about their fundamental biochemical and biophysical mechanisms. Here, we explored the ability of the microtubule‐severing enzyme katanin to depolymerize stabilized microtubules. Interestingly, we found that the tubulin C‐terminal tail (CTT), which is required for severing, is not required for katanin‐catalyzed depolymerization. We also found that the depolymerization of microtubules lacking the CTT does not require ATP or katanin\u27s ATPase activity, although the ATP turnover enhanced depolymerization. We also observed that the depolymerization rate depended on the katanin concentration and was best described by a hyperbolic function. Finally, we demonstrate that katanin can bind to filaments that lack the CTT, contrary to previous reports. The results of our work indicate that microtubule depolymerization likely involves a mechanism in which binding, but not enzymatic activity, is required for tubulin dimer removal from the filament ends

Increase in Intake Capacity by Dynamic Operation of Injection Wells

The method of pumping water to compensate for fluid withdrawals from an oil formation in order to maintain formation pressure has long established itself as an effective technology and is widely used at oil and gas fields. At the same time, field operator is often faced with the problem of reduction in the intake capacity of injection wells, which may be caused by various complications arising in the near-wellbore area due to a violation of water treatment technology or other factors. This problem is typical for reservoirs with low permeability values, which leads to a decrease in the performance indicators of the formation pressure maintenance system. In order to counter contamination of the bottomhole zone of the well, as a rule, injection of specialized acid compositions for the purpose of cleaning is used. To increase the effectiveness of this procedure, the authors of the article propose to discharge the injection well at the maximum permissible speeds. This event will allow primary cleaning of the bottomhole zone of the formation from moving particles clogging the pore space, and reduce formation pressure in the vicinity of the injection well, which will subsequently improve the intake capacity of the well during treatment with acid compositions. The decrease in formation pressure in the bottomhole zone of the well also has a positive effect on the radius of acid penetration into the formation. The proposed approach has been successfully tested on a number of injection wells at one of «Gazprom Neft» enterprises. The results of pilot operations showed an increase in the quality of cleaning the bottomhole zone of the formation and an increase in the intake capacity of injection wells with subsequent preservation of intake dynamics

ОПЫТ ПРИМЕНЕНИЯ ЭРИБУЛИНА В УСЛОВИЯХ РЕАЛЬНОЙ КЛИНИЧЕСКОЙ ПРАКТИКИ

Background: Eribulin mesylate was initially approved in 2010 by FDA as a third-line treatment for women with advanced breast cancer (ABC) pretreated with at least two lines of chemotherapy, and then in 2011 it was approved by EMA as a second-line therapy. Patients should have received an anthracycline and a taxane in either the adjuvant or metastatic setting. Since then, several studies have been conducted confirming its efficacy and safety. We report our experience of using eribulin in our centre in a real-life clinical setting.Materials and methods: 34 patients with ABC were enrolled to receive eribulin. From February 2016 to February 2017, patients were treated with standard doses of eribulin and evaluated for toxicity and responses. All of them had previously received anthracyclines and taxanes in either the adjuvant or metastatic setting. Median age was 60 years (range: 39–79). ECOG performance status was 1 or 2 at the time of enrollment. Median number of cycles of eribulin was 5 (range 2–10). Patients received eribulin from first-line chemotherapy to seventh-line chemotherapy for ABC. Median number of envolved visceral organs was 2 (range 1–4).Results: There were no complete responses. Partial responses were achieved in 26.4% (9/34), stabilization of the disease in 32.4% (11/34) and progression of the disease in 41.2% (14/34) of patients. The median progression-free survival was 4.09 months (range: 2.6–6.53). Main toxicities (grade 3–4) included peripheral neuropathy and neutropenia. Neuropathy was marked in 14.7% (5/34) and neutropenia in 14.7% (5/34) of patients. Dose reductions were required in 14.7% (5/34) of patients because of neutropenia.Conclusion: Our experience shows that eribulin has clinical activity as well as satisfactory tolerability in unselected patients in a reallife clinical setting. Thus, in our opinion, eribulin can represent a new option in treatment of ABC patients.Введение: Эрибулин впервые был зарегистрирован FDA в 2010 г. в качестве 3 линии терапии у пациентов с метастатическим раком молочной железы (мРМЖ), ранее получивших по крайней мере 2 линии химиотерапии по поводу распространенного процесса, включавшие антрациклины и таксаны. Далее в 2011 г. EMA одобрила эрибулин в качестве 2 линии химиотерапии. Пациенты должны были получать антрациклины и таксаны или в адъювантном, или лечебном режиме. К настоящему времени опубликован ряд исследований, подтверждающих эффективность и безопасность препарата. В настоящей работе представлен собственный опыт применения эрибулина в условиях реальной клинической практики.Пациенты и методы: С февраля 2016 по февраль 2017 г. лечение эрибулином получили 34 пациента с прогрессирующим мРМЖ с последующей оценкой эффективности и безопасности препарата. Все больные получили предшествующую терапию с использованием антрациклинов и таксанов по поводу местнораспространенного и/или метастатического рака. Средний возраст пациентов на момент включения в исследование составил 60 лет (от 39 до 79 лет). Статус общего состояния по шкале ECOG на момент включения был от 0 до 2. Медиана числа проведенных курсов химиотерапии эрибулином составила 5 (от 2 до 10 курсов). Пациенты получали эрибулин с первой по седьмую линии химиотерапии по поводу мРМЖ. Среднее количество пораженных органов – 2 (от 1 до 4 органов).Результаты: Полных регрессией отмечено не было. Частичная регрессия отмечена у 26,4% (9/34) пациентов, стабилизация болезни достигнута у 32,4% (11/34). Прогрессирование болезни зафиксировано у 41,2% (14/34) пациентов. Медиана выживаемости без прогрессирования на терапии эрибулином мРМЖ составила 4,09 (95% ДИ 2,6–6,53) месяца. Наиболее клинически значимой (3–4 степени) токсичностью стали нейтропения и полинейропатия. Нейтропения была отмечена у 14,7% (5/34), полинейропатия также у 14,7% (5/34) пациентов. 5 больным (14,7%) потребовалась редукция дозы эрибулина в связи с нейтропенией.Выводы: Проведенный нами анализ демонстрирует, что эрибулин является активным препаратом с предсказуемым и управляемым профилем безопасности при лечении пациентов с мРМЖ в условиях реальной клинической практики. Таким образом, по нашему мнению, эрибулин может стать новым вариантом лечения пациентов с мРМЖ

Oxide charge evolution under crystallization of amorphous Li–Nb–O films

Li–Nb–O amorphous films were deposited onto Si substrates by the radio-frequency magnetron sputtering method in an Ar environment and an Ar(60%)+O2(40%) gas mixture. A positive effective fixed oxide charge Qeff having negative, -Qeff, and positive, +Qeff, components, exists in the as-grown heterostructures. -Qeff is located near the substrate/film interface, whereas + Qeff is determined by a deficit of Li and O (vacancies) in the bulk of Li–Nb–O films. As-grown films crystallized under thermal annealing (TA) at temperatures up to 600 °C and revealed the formation of polycrystalline LiNbO3. TA at about 520 °C resulted in the formation of the second phase LiNb3O8, increasing + Qeff, and compensating -Qeff entirely. The dielectric constants of the as-grown films exhibit two peaks at the annealing temperatures of 450 °C and 550 °C, which are attributed to the total crystallization and recrystallization of the LN films under TA, respectively. © 2020 The AuthorsRussian Foundation for Basic Research, RFBR: 18-29-11062, 18-32-00959This research was supported by the Russian Foundation for Basic Research (Grant № 18-29-11062 and Grant № 18-32-00959 ). The equipment of the Ural Center for Shared Use “Modern Nanotechnology” of the Ural Federal University was used

A Simple Way to Control the Filling Degree of the SiO2/Si Template Pores With Nickel

The paper demonstrates a simple way to control the filling degree of the pores of a silicon oxide template on silicon substrate with nickel. SiO2/Si template was formed using the swift heavy ion tracks technology, which includes irradiation with high energy ions and chemical transformation of the obtained latent tracks into the pores. The preparation of SiO2(Ni)/Si nanostructures with different filling degree of pores in SiO2 with nickel was performed using the electrodeposition method by changing the duration of the process. A study and analysis of the morphology of SiO2(Ni)/Si nanostructures using scanning electron and atomic force microscopy was carried out to determine the nature of pore filling by metal. © 2019 Elsevier Ltd.The authors acknowledge the support of the work in frames of H2020 - MSCA - RISE2017 - 778308 - SPINMULTIFILM Project and the Scientific-technical program ‘Technology-SG’ [project number 3.1.5.1]

Характер и взаимосвязь изменений перекисного окисления липидов и иммунитета у больных острой пневмонией

The character and connection between changes of peroxide lipid oxidation and immune profile were studied in 325 patients with acute pneumonia in different courses of the disease. It was found that inflammatory process in pulmonary tissue was accompanied with expressed intensification of peroxide lipid oxidation processes, with the decrease of the antiperoxide protection level, and immunodeficiency state formation. The most expressed secondary immunodeficiency corresponded to the highest peroxide lipid oxidation level and the considerable decrease of antiperoxide protection. The author presumed that peroxide lipid oxidation processes and connected changes of peroxide protection lead to universal membrane pathology during the abundance of the primary factor and the lack of the latter are the most common mechanisms of the inflammation in the lung tissue. The authors suppose that the study of the peroxide lipid oxidation character in connection with changes of other organs and systems allows to outlying the essence of pathological process in the pulmonary tissue, to estimate mechanisms of reparation (the sanogenesis) of the morphological structure and the function of the lung, and to elaborate measures for correction of the revealed dysfunction.У 325 больных острой пневмонией изучены характер и взаимосвязь изменений перекисного окисления липидов (ПОЛ) и иммунитета при различном течении острой пневмонии. Обнаружено, что воспалительный процесс в легочной ткани сопровождается выраженной интенсификацией процессов ПОЛ, снижением уровня антиоксидантной защиты (АОЗ) и формированием иммунодефицитного состояния. Наиболее высокому уровню ПОЛ и значительному снижению мощности АОЗ соответствует и наиболее значительный вторичный иммунодефицит. Авторами высказано предположение, что наиболее общим механизмом развития воспаления в легочной ткани являются процессы ПОЛ и сопряженные с ними изменения АОЗ, вызывающие при избыточности первого и недостаточности второго формирование универсальной мембранной патологии. Авторы полагают, что изучение характера ПОЛ во взаимосвязи с изменениями других органов и систем позволит глубже проникнуть в суть патологического процесса в легочной ткани, оценить механизмы восстановления (саногенеза) морфологической структуры и функции легких, разработать мероприятия по коррекции выявленных нарушений

ОСОБЕННОСТИ ФОРМИРОВАНИЯ МЕДНОГО ОСАДКА В ПОРАХ ДИОКСИДА КРЕМНИЯ

Using the SiO2 porous templates on silicon substrate, Si/SiO2(Cu) nanostructures have been synthesized by electrochemical method. A comprehensive study by means of scanning electron, transmission electron, atomic force microscopy and diffraction analysis techniques have been conducted. The morphological features and the lateral dimensions of metal nanostructures, deposited in the pores, have been defined. A tendency to form copper agglomerates with dendritic shape have been shown. This structures are promising for using as catalyst or substrates for SERS.С использованием SiO2-пористых шаблонов на кремниевой подложке электрохимическим методом синтезированы наноструктуры Si/SiO2(Cu). Проведено их всестороннее изучение посредством электронной сканирующей, электронной просвечивающей, атомно-силовой микроскопии и дифракционных методов анализа. Определены морфологические особенности и латеральные размеры металлического осадка в порах. Показана тенденция к образованию агломератов меди дендритной формы, что указывает на перспективность использования таких структур при катализе и в спектроскопии гигантского комбинационного рассеяния света