A Guide to Standards-Based Learning

This learning module educates parents/guardians and teachers new to the practice to understand what standards-based learning is, why a school system would use it, how to know when students are learning the standards, and the difference from traditional learning. View professional learning module.https://digitalcommons.gardner-webb.edu/improve/1032/thumbnail.jp

Reference to index of papers of John Leake (1780-1865) of Rosedale, near Campbell Town Pt. 2

John Leake (1780-1865) was born in Kent, U.K., in 1780, son of Robert and Sarah Leake. The family were merchants connected with the firm of Travis and Leake of Hull and John worked as a shipping and cargo agent, trading in various commodities between Hamburg, Hull, and North Sea and Mediterranean ports. In Hull in 1805 he married Elizabeth the daughter of a Hull merchant, William Bell, and between 1806 and 1819 they had six sons and two daughters, but one daughter died in childhood. After the Napoleonic Wars Leake and his family settled in Hamburg, an important trading centre and home for many British merchants, where he acted as agent for a number of East Yorkshire and German business companies, especially in agricultural produce, linseed oil, whale oil, cotton, etc. In the 1820s and 1830s, however, business began to decline and many of the Anglo-German merchant community emigrated. Leake was encouraged by William Wilberforce and the British consul in Hamburg to emigrate to Van Diemen's Land and he and his family sailed from Leith in 1822 and arrived in Hobart in 1823. The family settled near Campbell Town in the Midlands where many other former merchants of Hamburg and Altona (Holstein) settled, including Lewis Gilles and the Oakden and Milliken families etc. Others, later settled in South Australia, including Osmond Gilles and two of Leake's sons, Robert and Edward. Leake still kept in touch with friends and relatives in Hamburg and Hull. Former business associates acted as Leake's agents for the sale of wool and other business, especially Leake's father-in-law William Bell of Hull and his son, William Bell jr. Leake's father-in-law left property in Hull, in the street called "Land of Green Ginger", in trust for the education of Leake's son John Travis Leake as a surgeon, the residue for Bell's daughter Elizabeth Leake and then for Elizabeth's other children (see L.l/D.277-99). John T. Leake studied medicine in Kiel and Dublin and later received an MD. from Kiel University. William Bell the younger offered to educate a younger son, Arthur, and teach him the merchant business, so he was sent back to Hull and spent some years there and also in Hamburg with his other uncle Edward John Bell. One of Edward Bell's daughters, Clara, came to live with the Leakes in 1857 and in 1869 married the youngest son, Charles. Bell's son Ernst joined Robert Leake at Glencoe for a few years and then settled at Mt. Drummond near Port Lincoln, South Australia. Another son, Edward Geiss settled in Queensland, and after their father's death the youngest sister, Helen, came out to join the Leake family at Campbell Town in 1878

Reference to index of papers of John Leake (1780-1865) of Rosedale, near Campbell Town

John Leake (1780-1865) was born in Kent, U.K., in 1780, son of Robert and Sarah Leake. The family were merchants connected with the firm of Travis and Leake of Hull and John worked as a shipping and cargo agent, trading in various commodities between Hamburg, Hull, and North Sea and Mediterranean ports. In Hull in 1805 he married Elizabeth the daughter of a Hull merchant, William Bell, and between 1806 and 1819 they had six sons and two daughters, but one daughter died in childhood. After the Napoleonic Wars Leake and his family settled in Hamburg, an important trading centre and home for many British merchants, where he acted as agent for a number of East Yorkshire and German business companies, especially in agricultural produce, linseed oil, whale oil, cotton, etc. In the 1820s and 1830s, however, business began to decline and many of the Anglo-German merchant community emigrated. Leake was encouraged by William Wilberforce and the British consul in Hamburg to emigrate to Van Diemen's Land and he and his family sailed from Leith in 1822 and arrived in Hobart in 1823. The family settled near Campbell Town in the Midlands where many other former merchants of Hamburg and Altona (Holstein) settled, including Lewis Gilles and the Oakden and Milliken families etc. Others, later settled in South Australia, including Osmond Gilles and two of Leake's sons, Robert and Edward. Leake still kept in touch with friends and relatives in Hamburg and Hull. Former business associates acted as Leake's agents for the sale of wool and other business, especially Leake's father-in-law William Bell of Hull and his son, William Bell jr. Leake's father-in-law left property in Hull, in the street called "Land of Green Ginger", in trust for the education of Leake's son John Travis Leake as a surgeon, the residue for Bell's daughter Elizabeth Leake and then for Elizabeth's other children (see L.l/D.277-99). John T. Leake studied medicine in Kiel and Dublin and later received an MD. from Kiel University. William Bell the younger offered to educate a younger son, Arthur, and teach him the merchant business, so he was sent back to Hull and spent some years there and also in Hamburg with his other uncle Edward John Bell. One of Edward Bell's daughters, Clara, came to live with the Leakes in 1857 and in 1869 married the youngest son, Charles. Bell's son Ernst joined Robert Leake at Glencoe for a few years and then settled at Mt. Drummond near Port Lincoln, South Australia. Another son, Edward Geiss settled in Queensland, and after their father's death the youngest sister, Helen, came out to join the Leake family at Campbell Town in 1878. From Leake Family Papers L

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

One of the most common symptoms of Alzheimer\u27s disease (AD) and related tauopathies is memory loss. The exact mechanisms leading to memory loss in tauopathies are not yet known; however, decreased translation due to ribosomal dysfunction has been implicated as a part of this process. Here we use a proteomics approach that incorporates subcellular fractionation and coimmunoprecipitation of tau from human AD and non-demented control brains to identify novel interactions between tau and the endoplasmic reticulum (ER). We show that ribosomes associate more closely with tau in AD than with tau in control brains, and that this abnormal association leads to a decrease in RNA translation. The aberrant tau–ribosome association also impaired synthesis of the synaptic protein PSD-95, suggesting that this phenomenon contributes to synaptic dysfunction. These findings provide novel information about tau-protein interactions in human brains, and they describe, for the first time, a dysfunctional consequence of tau–ribosome associations that directly alters protein synthesis

Sugar-sweetened beverage intake and cardiovascular risk factor profile in youth with type 1 diabetes: application of measurement error methodology in the SEARCH Nutrition Ancillary Study

The SEARCH Nutrition Ancillary Study aims to investigate the role of dietary intake on the development of long-term complications of type 1 diabetes in youth, and capitalise on measurement error (ME) adjustment methodology. Using the National Cancer Institute (NCI) method for episodically consumed foods, we evaluated the relationship between sugar-sweetened beverage (SSB) intake and cardiovascular risk factor profile, with the application of ME adjustment methodology. The calibration sample included 166 youth with two FFQ and three 24 h dietary recall data within 1 month. The full sample included 2286 youth with type 1 diabetes. SSB intake was significantly associated with higher TAG, total and LDL-cholesterol concentrations, after adjusting for energy, age, diabetes duration, race/ethnicity, sex and education. The estimated effect size was larger (model coefficients increased approximately 3-fold) after the application of the NCI method than without adjustment for ME. Compared with individuals consuming one serving of SSB every 2 weeks, those who consumed one serving of SSB every 2 d had 3·7 mg/dl (0·04 mmol/l) higher TAG concentrations and 4·0 mg/dl (0·10 mmol/l) higher total cholesterol and LDL-cholesterol concentrations, after adjusting for ME and covariates. SSB intake was not associated with measures of adiposity and blood pressure. Our findings suggest that SSB intake is significantly related to increased lipid levels in youth with type 1 diabetes, and that estimates of the effect size of SSB on lipid levels are severely attenuated in the presence of ME. Future studies in youth with diabetes should consider a design that will allow for the adjustment for ME when studying the influence of diet on health status

Relative validity and reliability of a food frequency questionnaire in youth with type 1 diabetes

To evaluate the relative validity and reliability of the SEARCH food frequency questionnaire (FFQ) that was modified from the Block Kids Questionnaire

Plasma Nutrient Biomarkers Are Associated with Waist-to-Height Ratio in Youth with Type 1 Diabetes

Background: Plasma fatty acids (FAs) and micronutrients have been associated with central obesity in adults; however, previous studies of these associations in adults have yielded mixed results. In addition, no comparable research has been conducted among youth with type 1 diabetes (T1D)

The influence of curricula content on sociology students’ transformations: the case of feminist knowledge

Previous research identifies the importance of feminist knowledge for improving gender equity, economic prosperity and social justice for all. However, there are difficulties in embedding feminist knowledge in higher education curricula. Across England, undergraduate sociology is a key site for acquiring feminist knowledge. In a study of four English sociology departments, Basil Bernstein's theoretical concepts and Madeleine Arnot's notion of gender codes frame an analysis indicating that sociology curricula in which feminist knowledge is strongly classified in separate modules is associated with more women being personally transformed. Men's engagement with feminist knowledge is low and it does not become more transformative when knowledge is strongly classified. Curriculum, pedagogy and gender codes are all possible contributors to these different relationships with feminist knowledge across the sample of 98 students

Author Correction: Discovery of 42 genome-wide significant loci associated with dyslexia

Correction to: Nature Genetics https://doi.org/10.1038/s41588-022-01192-y. Published online 20 October 2022. In the version of this article originally published, a paragraph was omitted in the Methods section, reading “Genomic control. Top SNPs are reported from the more conservative GWAS results adjusted for genomic control (Fig. 1, Extended Data Figs. 1–4, and Supplementary Tables 1, 2, 9 and 10), whereas downstream analyses (including gene-set analysis, enrichment and heritability partitioning, genetic correlations, polygenic prediction, candidate gene replication) are based on GWAS results without genomic control.” The paragraph has now been included in the HTML and PDF versions of the article

Which outcome measurement instruments are used to measure core infant feeding outcomes in children up to 1 year of age? A scoping review protocol

BackgroundHow, what, and when infants are fed plays a role in the aetiology of childhood obesity. Heterogeneity in how infant feeding outcomes are measured in trials of interventions to prevent childhood obesity limits evidence syntheses and understanding of intervention effectiveness. An infant feeding core outcome set (COS) was previously developed to standardised outcome measurement and reporting. The COS represents what to measure; determining how best to measure these outcomes is the next essential step to improve intervention evaluations. The aim of this scoping review is therefore to identify what outcome measurement instruments have been used in trials, and how they have been used, to measure the core infant feeding outcomes.MethodsA scoping review will be conducted. MEDLINE, EMBASE, CINAHL, PsychINFO, the Cochrane Central Register of Controlled Trials, OpenGrey and GreyNet will be searched from inception. Papers areeligible for inclusion if they report trials involving primary data collection that measure and report at least one core infant feeding outcome in infants ≤one year of age. Following searching and screening, eligible studies will be categorised into the following four overarching categories for data extraction, synthesis and write-up: caregiver-related outcomes; diet-related outcomes; feeding environment outcomes; child weight outcomes. Data will be narratively described and presented in tabular format, with findings presented in four separate review papers delineated by the four overarching categories.DiscussionThis scoping review forms part of the Standardised measurement for Childhood Obesity Prevention (SCOPE) study (www.eiascope.com). Evidence from this scoping review on what measurement instruments are used, and how they are used, represents an essential first step in developing recommendations and guidance about how best to measure core infant feeding outcomes for childhood obesity prevention. This can improve evidence syntheses and understanding of what infant feeding interventions are most effective for childhood obesity prevention