PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

Abstract Background Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment. Methods All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals. Results A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death. Conclusion Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions. </jats:sec

'Commersonia rosea' (Malvaceae s.l.: Lasiopetaleae): a new, rare fire-ephemeral species from the upper Hunter Valley of New South Wales

'Commersonia rosea' S.A.J. Bell &amp; L.M. Copel., a fire-ephemeral species from the Central Western Slopes of New South Wales is described as new. Notes on its distribution, ecology and conservation status are given. The species is currently known from just four small populations, totalling c. 200 plants, and is considered endangered

Bird richness and composition along an agricultural gradient in New Guinea: The influence of land use, habitat heterogeneity and proximity to intact forest

We examined variation in bird species richness, abundance and guild composition along an agricultural gradient in New Guinea, and looked for any additive influence of habitat heterogeneity on these variables. The study was based on a grid of survey plots, six plots wide and 24 plots long with the long axis running from a settlement 2.4 km through active and abandoned agricultural plots towards a large area of forest. Each circular survey plot (25 m radius) was assigned to a broad habitat type, ten habitat measures taken, and birds counted for 1 h in each plot. Principal component analysis (PCA) habitat axis 1 described an axis of decreasing forest alteration (larger trees, greater tree densities, fuller canopy) that was positively correlated with distance from the settlement. Bird richness and abundance were highest at intermediate disturbance levels (plots with mid-range axis 1 scores). Proportions of insectivores and frugivores increased with decreasing forest alteration, while proportions of nectarivores decreased. We calculated three measures of habitat heterogeneity by comparing each plot's PCA score to those of eight neighbouring plots (50–110 m away). These measures reflected how different the plot was to its neighbours, how variable the habitat was around the plot, and the degree to which the plot bordered less disturbed forest. We related these measures to plot bird variable scores independently, and to residuals following regressions of bird scores against PCA scores. Heterogeneity measures had no significant influence on abundance or richness measures, but there were greater proportions of frugivores in plots showing a given degree of habitat alteration if they bordered more pristine habitat. While we readily identified differences in bird communities along the agricultural gradient, the influences of habitat heterogeneity were not striking for birds at this fine scale

Effects of dispersal and selection on stochastic assembly in microbial communities.

Stochastic processes can play an important role in microbial community assembly. Dispersal limitation is one process that can increase stochasticity and obscure relationships between environmental variables and microbial community composition, but the relationship between dispersal, selection and stochasticity has not been described in a comprehensive way. We examine how dispersal and its interactions with drift and selection alter the consistency with which microbial communities assemble using a realistic, individual-based model of microbial decomposers. Communities were assembled under different environmental conditions and dispersal rates in repeated simulations, and we examined the compositional difference among replicate communities colonizing the same type of leaf litter ('within-group distance'), as well as between-group deterministic selection. Dispersal rates below 25% turnover per year resulted in high within-group distance among communities and no significant environmental effects. As dispersal limitation was alleviated, both within- and between-group distance decreased, but despite this homogenization, deterministic environmental effects remained significant. In addition to direct effects of dispersal rate, stochasticity of community composition was influenced by an interaction between dispersal and selection strength. Specifically, communities experiencing stronger selection (less favorable litter chemistries) were more stochastic, possibly because lower biomass and richness intensified drift or priority effects. Overall, we show that dispersal rate can significantly alter patterns of community composition. Partitioning the effects of dispersal, selection and drift based on static patterns of microbial composition will be difficult, if not impossible. Experiments will be required to tease apart these complex interactions between assembly processes shaping microbial communities