2,377 research outputs found

    Why we might not need to stress about ruling out inducible myocardial ischemia

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    Editorial on the high-sensitivity cardiac troponin (hs-cTn) tests

    Premature mortality in refractory partial epilepsy: does surgical treatment make a difference?

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    Background: Epilepsy carries an increased risk of premature death. For some people with intractable focal epilepsy, surgery offers hope for a seizure-free life. The authors aimed to see whether epilepsy surgery influenced mortality in people with intractable epilepsy. Methods: The authors audited survival status in two cohorts (those who had surgery and those who had presurgical assessment but did not have surgery). Results: There were 40 known deaths in the non-surgical group (3365 person years of follow-up) and 19 in the surgical group (3905 person-years of follow-up). Non-operated patients were 2.4 times (95% CI 1.4 to 4.2) as likely to die as those who had surgery. They were 4.5 times (95% CI 1.9 to 10.9) as likely to die a probable epilepsy-related death. In the surgical group, those with ongoing seizures 1 year after surgery were 4.0 (95% CI 1.2 to 13.7) times as likely to die as those who were seizure-free or who had only simple partial seizures. Time-dependent Cox analysis showed that the yearly outcome group did not significantly affect mortality (HR 1.3, 95% CI 0.9 to 1.8). Conclusion: Successful epilepsy surgery was associated with a reduced risk of premature mortality, compared with those with refractory focal epilepsy who did not have surgical treatment. To some extent, the reduced mortality is likely to be conferred by inducing freedom from seizures. It is not certain whether better survival is attributable only to surgery, as treatment decisions were not randomised, and there may be inherent differences between the groups.<br/

    Employment insecurity and life satisfaction: The moderating influence of labour market policies across Europe

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    This article tests whether the link between employment insecurity and life satisfaction is moderated by the generosity of labour market policies across Europe. Employment insecurity provokes anxieties about (a) the difficulties of finding a new job and (b) alternative sources of non-work income. These components can be related to active and passive labour market policies, respectively. Generous policy support is thus expected to buffer the negative consequences of employment insecurity by lowering the perceived difficulty of finding a similar job or providing income maintenance during unemployment. Based on data for 22 countries from the 2010 European Social Survey, initial support for this hypothesis is found. Perceived employment insecurity is negatively associated with life satisfaction but the strength of the relationship is inversely related to the generosity of labour market policies. Employment insecurity, in other words, is more harmful in countries where labour market policies are less generous

    \Lambda-buildings and base change functors

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    We prove an analog of the base change functor of \Lambda-trees in the setting of generalized affine buildings. The proof is mainly based on local and global combinatorics of the associated spherical buildings. As an application we obtain that the class of generalized affine building is closed under ultracones and asymptotic cones. Other applications involve a complex of groups decompositions and fixed point theorems for certain classes of generalized affine buildings.Comment: revised version, 29 pages, to appear in Geom. Dedicat

    Candidates for a possible third-generation gravitational wave detector: comparison of ring-Sagnac and sloshing-Sagnac speedmeter interferometers

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    Speedmeters are known to be quantum non-demolition devices and, by potentially providing sensitivity beyond the standard quantum limit, become interesting for third generation gravitational wave detectors. Here we introduce a new configuration, the sloshing-Sagnac interferometer, and compare it to the more established ring-Sagnac interferometer. The sloshing-Sagnac interferometer is designed to provide improved quantum noise limited sensitivity and lower coating thermal noise than standard position meter interferometers employed in current gravitational wave detectors. We compare the quantum noise limited sensitivity of the ring-Sagnac and the sloshing-Sagnac interferometers, in the frequency range, from 5 Hz to 100 Hz, where they provide the greatest potential benefit. We evaluate the improvement in terms of the unweighted noise reduction below the standard quantum limit, and by finding the range up to which binary black hole inspirals may be observed. The sloshing-Sagnac was found to give approximately similar or better sensitivity than the ring-Sagnac in all cases. We also show that by eliminating the requirement for maximally-reflecting cavity end mirrors with correspondingly-thick multi-layer coatings, coating noise can be reduced by a factor of approximately 2.2 compared to conventional interferometers

    Topos-Theoretic Extension of a Modal Interpretation of Quantum Mechanics

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    This paper deals with topos-theoretic truth-value valuations of quantum propositions. Concretely, a mathematical framework of a specific type of modal approach is extended to the topos theory, and further, structures of the obtained truth-value valuations are investigated. What is taken up is the modal approach based on a determinate lattice \Dcal(e,R), which is a sublattice of the lattice \Lcal of all quantum propositions and is determined by a quantum state ee and a preferred determinate observable RR. Topos-theoretic extension is made in the functor category \Sets^{\CcalR} of which base category \CcalR is determined by RR. Each true atom, which determines truth values, true or false, of all propositions in \Dcal(e,R), generates also a multi-valued valuation function of which domain and range are \Lcal and a Heyting algebra given by the subobject classifier in \Sets^{\CcalR}, respectively. All true propositions in \Dcal(e,R) are assigned the top element of the Heyting algebra by the valuation function. False propositions including the null proposition are, however, assigned values larger than the bottom element. This defect can be removed by use of a subobject semi-classifier. Furthermore, in order to treat all possible determinate observables in a unified framework, another valuations are constructed in the functor category \Sets^{\Ccal}. Here, the base category \Ccal includes all \CcalR's as subcategories. Although \Sets^{\Ccal} has a structure apparently different from \Sets^{\CcalR}, a subobject semi-classifier of \Sets^{\Ccal} gives valuations completely equivalent to those in \Sets^{\CcalR}'s.Comment: LaTeX2

    Transcranial Doppler Directed Dextran Therapy in the Prevention of Carotid Thrombosis: Three Hour Monitoring is as Effective as Six Hours

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    AbstractBackgroundsix hours» monitoring by transcranial Doppler (TCD) has been successful in directing Dextran therapy in patients at high risk of thrombotic stroke after carotid endarterectomy (CEA).Objectivesis 3 h of routine monitoring as effective as 6 h in the prevention of early postoperative thrombotic stroke?Designprospective, consecutive study in all patients with an accessible cranial window.Methodsone hundred and sixty-six patients undergoing CEA underwent 3 h of postoperative monitoring by TCD. Any patient with >25 emboli detected in any 10 min period or those with emboli that distorted the arterial waveform were commenced on an incremental infusion of dextran 40.Resultsthe majority of patients destined to embolise will do so within the first 2 postoperative hours. Dextran therapy was instituted in nine patients (5%) and rapidly controlled this phase of embolisation although the dose had to be increased in three (33%). No patient suffered a postoperative carotid thrombosis but one suffered a minor stroke on day 5 and was found to have profuse embolisation on TCD; high dose dextran therapy was again instituted, the embolus count rate fell rapidly and he made a good recovery thereafter. Overall, the death and disabling stroke rate was 1.2% and the death/any stroke rate was 2.4%.Conclusionthree hours of postoperative TCD monitoring is as effective as 6 h in the prevention of postoperative carotid thrombosis

    Electromagnetic corrections in the anomaly sector

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    Chiral perturbation theory in the anomaly sector for Nf=2N_f=2 is extended to include dynamical photons, thereby allowing a complete treatment of isospin breaking. A minimal set of independent chiral lagrangian terms is determined and the divergence structure is worked out. There are contributions from irreducible and also from reducible one-loop graphs, a feature of ChPT at order larger than four. The generating functional is non-anomalous at order e2p4e^2p^4, but not necessarily at higher order in e2e^2. Practical applications to γπππ\gamma\pi\to\pi\pi and to the π02γ\pi^0\to2\gamma amplitudes are considered. In the latter case, a complete discussion of the corrections beyond current algebra is presented including quark mass as well as electromagnetic effects.Comment: 26 pages, 3 figure
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