4,218 research outputs found
Experiences and perceptions of Spring Lane Sure Start Children's Centre
Spring Lane Sure Start Children’s Centre was designated in September 2007, and ‘officially opened’ in February 2009. The Centre is housed in refurbished premises within a nursery/school complex in the heart of Northampton and offers diverse health, childcare, early education and support services delivered by a multi-professional team. These services and activities are available to children aged 0-5 years old, and their parents/carers, residing within a catchment area comprising eight ‘Super Output Areas’ in the Castle and St. James ward of Northampton.
In April 2009, the Centre for Children and Youth (CCY) – a research centre based at The University of Northampton – was commissioned by Spring Lane Sure Start Children’s Centre to collate and gather evaluative data regarding experiences and perceptions of the Children’s Centre during its first year of activitie
Spatially Resolved Galaxy Star Formation and its Environmental Dependence I
We use the photometric information contained in individual pixels of 44,964
(0.019<z<0.125 and -23.5<M_r<-20.5) galaxies in the Fourth Data Release (DR4)
of the Sloan Digital Sky Survey to investigate the effects of environment on
galaxy star formation (SF). We use the pixel-z technique, which combines
stellar population synthesis models with photometric redshift template fitting
on the scale of individual pixels in galaxy images. Spectral energy
distributions are constructed, sampling a wide range of properties such as age,
star formation rate (SFR), dust obscuration and metallicity. By summing the
SFRs in the pixels, we demonstrate that the distribution of total galaxy SFR
shifts to lower values as the local density of surrounding galaxies increases,
as found in other studies. The effect is most prominent in the galaxies with
the highest star formation, and we see the break in the SFR-density relation at
a local galaxy density of (Mpc/h). Since our method
allows us to spatially resolve the SF distribution within galaxies, we can
calculate the mean SFR of each galaxy as a function of radius. We find that on
average the mean SFR is dominated by SF in the central regions of galaxies, and
that the trend for suppression of SFR in high density environments is driven by
a reduction in this nuclear SF. We also find that the mean SFR in the outskirts
is largely independent of environmental effects. This trend in the mean SFR is
shared by galaxies which are highly star forming, while those which are weakly
star forming show no statistically significant correlation between their
environment and the mean SFR at any radius.Comment: 37 pages, 11 figures. Referee's comments included and matches version
accepted for publication in the Astrophysical Journal. For high resolution
figures, see http://www.phyast.pitt.edu/~welikala/pixelz/paper1
Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections
BACKGROUND: Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance. METHODS: The effects of drug treatment on within-host competition were studied using the rodent malaria Plasmodium chabaudi. Mice were infected simultaneously with a drug-resistant and a drug-sensitive clone and were then either drug-treated or left untreated. Transmission was assessed by feeding mice to Anopheles stephensi mosquitoes. RESULTS: In the absence of drugs, the sensitive clone competitively suppressed the resistant clone; this resulted in lower asexual parasite densities and also reduced transmission to the mosquito vector. Drug treatment, however, allowed the resistant clone to fill the ecological space emptied by the removal of the sensitive clone, allowing it to transmit as well as it would have done in the absence of competition. CONCLUSION: These results show that under drug pressure, resistant strains can have two advantages: (1) they survive better than sensitive strains and (2) they can exploit the opportunities presented by the removal of their competitors. When mixed infections are common, such effects could increase the spread of drug resistance
Better Bell Inequality Violation by Collective Measurements
The standard Bell inequality experiments test for violation of local realism
by repeatedly making local measurements on individual copies of an entangled
quantum state. Here we investigate the possibility of increasing the violation
of a Bell inequality by making collective measurements. We show that
nonlocality of bipartite pure entangled states, quantified by their maximal
violation of the Bell-Clauser-Horne inequality, can always be enhanced by
collective measurements, even without communication between the parties. For
mixed states we also show that collective measurements can increase the
violation of Bell inequalities, although numerical evidence suggests that the
phenomenon is not common as it is for pure states.Comment: 7 pages, 4 figures and 1 table; references update
Uplift and Seismicity driven by Magmatic Inflation at Sierra Negra Volcano, Galápagos Islands
Catalogue of detected earthquakes and cGPS uplift timeseries for Sierra Negra Volcano, Galapagos Island
Bounds on Quantum Correlations in Bell Inequality Experiments
Bell inequality violation is one of the most widely known manifestations of
entanglement in quantum mechanics; indicating that experiments on physically
separated quantum mechanical systems cannot be given a local realistic
description. However, despite the importance of Bell inequalities, it is not
known in general how to determine whether a given entangled state will violate
a Bell inequality. This is because one can choose to make many different
measurements on a quantum system to test any given Bell inequality and the
optimization over measurements is a high-dimensional variational problem. In
order to better understand this problem we present algorithms that provide, for
a given quantum state, both a lower bound and an upper bound on the maximal
expectation value of a Bell operator. Both bounds apply techniques from convex
optimization and the methodology for creating upper bounds allows them to be
systematically improved. In many cases these bounds determine measurements that
would demonstrate violation of the Bell inequality or provide a bound that
rules out the possibility of a violation. Examples are given to illustrate how
these algorithms can be used to conclude definitively if some quantum states
violate a given Bell inequality.Comment: 13 pages, 1 table, 2 figures. Updated version as published in PR
Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases
Multifocal pupillographic objective perimetry (mfPOP) shows regions of slight hypersensitivity away from retinal regions damaged by diabetes or age-related macular degeneration (AMD). This study examines if such results also appear in multifocal visual evoked potentials (mfVEPs) recorded on the same day in the same patients. The pupil control system receives input from the extra-striate cortex, so we also examined evidence for such input. We recruited subjects with early type 2 diabetes (T2D) with no retinopathy, and patients with unilateral exudative AMD. Population average responses of the diabetes patients, and the normal fellow eyes of AMD patients, showed multiple regions of significant hypersensitivity (p < 0.05) on both mfPOP and mfVEPs. For mfVEPs the occipital electrodes showed fewer hypersensitive regions than the surrounding electrodes. More advanced AMD showed regions of suppression becoming centrally concentrated in the exudative AMD areas. Thus, mfVEP electrodes biased towards extra-striate cortical responses (surround electrodes) appeared to show similar hypersensitive visual field locations to mfPOP in early stage diabetic and AMD damage. Our findings suggest that hypersensitive regions may be a potential biomarker for future development of AMD or non-proliferative diabetic retinopathy, and may be more informative than visual acuity which remains largely undisturbed during early disease
Key Biofouling Organisms in Tidal Habitats Targeted by the Offshore Renewable Energy Sector in the North Atlantic Include the Massive Barnacle Chirona hameri
Marine habitats are being targeted for the extraction of offshore renewable energy (ORE) as part of the drive to decarbonise electricity generation. Unmanaged biofouling impacts ORE devices and infrastructure by elevating drag forces, increasing weight, and accelerating corrosion, leading to decreased performance and survivability, and extending costly periods of maintenance. ORE deployments in high tidal flow locations are providing opportunities to study the biofouling unique to these habitats. In this study, surveys of numerous devices and associated infrastructure deployed at the European Marine Energy Centre in Scotland identified high tidal flow fouling assemblages. Substrate orientation relative to tidal flow appears to affect the abundance of key fouling species, including the massive barnacle Chirona hameri. This species is shown to recruit to a wide range of artificial substrates, over a prolonged period from mid-spring to mid-summer, and in maximum current speeds from 0.4–4.0 m/s. For the first time, C. hameri is reported in near-surface depths, on uncoated components of a floating tidal device. The highly gregarious settlement behaviour and rapid growth exhibited by this species may have important implications for managing fouling in the ORE industry, especially in ‘niche’ areas. Anti-fouling strategies and maintenance scheduling applicable to ORE and other marine industries are discussed
Non-Equilibrium Quantum Dissipation
Dissipative processes in non-equilibrium many-body systems are fundamentally
different than their equilibrium counterparts. Such processes are of great
importance for the understanding of relaxation in single molecule devices. As a
detailed case study, we investigate here a generic spin-fermion model, where a
two-level system couples to two metallic leads with different chemical
potentials. We present results for the spin relaxation rate in the nonadiabatic
limit for an arbitrary coupling to the leads, using both analytical and exact
numerical methods. The non-equilibrium dynamics is reflected by an exponential
relaxation at long times and via complex phase shifts, leading in some cases to
an "anti-orthogonality" effect. In the limit of strong system-lead coupling at
zero temperature we demonstrate the onset of a Marcus-like Gaussian decay with
{\it voltage difference} activation. This is analogous to the equilibrium
spin-boson model, where at strong coupling and high temperatures the spin
excitation rate manifests temperature activated Gaussian behavior. We find that
there is no simple linear relationship between the role of the temperature in
the bosonic system and a voltage drop in a non-equilibrium electronic case. The
two models also differ by the orthogonality-catastrophe factor existing in a
fermionic system, which modifies the resulting lineshapes. Implications for
current characteristics are discussed. We demonstrate the violation of
pair-wise Coulomb gas behavior for strong coupling to the leads. The results
presented in this paper form the basis of an exact, non-perturbative
description of steady-state quantum dissipative systems
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