Spatial distribution of Schistosoma mansoni infection before and after chemotherapy with two praziquantel doses in a community of Pernambuco, Brazil

Praziquantel chemotherapy has been the focus of the Schistosomiasis Control Program in Brazil for the past two decades. Nevertheless, information on the impact of selective chemotherapy against Schistosoma mansoni infection under the conditions confronted by the health teams in endemic municipalities remains scarce. This paper compares the spatial pattern of infection before and after treatment with either a 40 mg/kg or 60 mg/kg dose of praziquantel by determining the intensity of spatial cluster among patients at 180 and 360 days after treatment. The spatial-temporal distribution of egg-positive patients was analysed in a Geographic Information System using the kernel smoothing technique. While all patients became egg-negative after 21 days, 17.9% and 30.9% reverted to an egg-positive condition after 180 and 360 days, respectively. Both the prevalence and intensity of infection after treatment were significantly lower in the 60 mg/kg than in the 40 mg/kg treatment group. The higher intensity of the kernel in the 40 mg/kg group compared to the 60 mg/kg group, at both 180 and 360 days, reflects the higher number of reverted cases in the lower dose group. Auxiliary, preventive measures to control transmission should be integrated with chemotherapy to achieve a more enduring impact

Mapping the Risk of Soil-Transmitted Helminthic Infections in the Philippines

The authors thank the regional coordinators, regional directors, provincial health officers, provincial health team leaders, municipal health officers, medical technologists, midwives, and barangay health workers for their commitment, which was key to completing all the phases of the national prevalence survey. We would like to thank Prof. May Lebanan for assisting us in the preparation of the data set.Author Summary Soil-transmitted helminth (STH) infections with A. lumbricoides, T. trichiura and hookworms are endemic in all 80 provinces of the Philippines, but the spatial variation in the prevalence of these infections has not been previously described. This analysis revealed that while A. lumbricoides and T. trichiura infections were widespread and highly endemic, hookworm infections were more circumscribed to smaller foci in the Visayas and Mindanao. The results also suggest that it may be necessary to place greater emphasis on improving the provision of water, sanitation and the promotion of behavioral change for improved hygiene for the control and prevention of STH infections, particularly for hookworm.Yeshttp://www.plosntds.org/static/editorial#pee