9 research outputs found

    Cultural Resources Investigation Report Of The Proposed Hallsville ISD K-4 Elementary School Project In Harrison County, Texas

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    Sphere 3 Environmental, Inc. (Sphere 3) conducted an intensive pedestrian cultural resource survey of approximately 15.12 hectares (37.35 acres) of land designated as the Area of Potential Effects (APE) on October 28, 29, and 31, and November 6, 2019, in response to the proposed undertaking to construct the Hallsville ISD K - 4 School campus. The project sponsor and owner of the project area is the Hallsville Independent School District. The project area is situated wholly within the City of Longview, Texas. The project area is located on the southwest side of Loop 281 and the north side of Page Road in western Harrison County. The cultural resources survey was conducted under Texas Antiquities Permit Number 9146 to identify properties eligible for inclusion in the National Register of Historic Places (NRHP) or listing as a State Antiquities Landmark (SAL). A total of 81 shovel tests were excavated across the project area. Two archaeological sites, 41HS1024 and 41HS1025 were newly discovered by the survey. Site 41HS1024 was identified as a dual-component historic and indeterminate prehistoric, very low-density subsurface artifact distribution site. The site consists of five chipped stone flakes and flake fragments and two historic glass shards. Site 41HS1025 was identified as an early to middle 20th century historic, low-density subsurface and surface artifact scatter. Cultural objects recovered from shovel testing of the two newly recorded sites and all documents associated with this investigation were curated at the Texas Archeological Research Laboratory (TARL) in Austin, Texas. Site 41HS1024 and Site 41HS1025 have been evaluated as not eligible for inclusion in the NRHP or for listing as a SAL. Sphere 3 therefore recommends that construction of school campus buildings and facilities proceed as planned without further cultural resource investigations

    Cultural Resources Investigation Report Of The Proposed City Of Jefferson 48-Inch RCP (Pipeline) Drainage Improvements Along Valve Street In Marion County, Texas

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    Sphere 3 Environmental, Inc. (Sphere 3) conducted an intensive pedestrian cultural resources survey of approximately 0.12 hectares (0.29 acres) of land designated as the Project Area/Area of Potential Effects on September 16 and 17, 2020, in response to the proposed pipeline replacement in Jefferson, Texas. The City of Jefferson retained Sphere 3 to conduct a cultural resources survey of the proposed pipeline replacement location. The cultural resources survey was conducted to identify properties eligible for inclusion in the National Register of Historic Places (NRHP) or worthy of listing as a State Antiquities Landmark (SAL). A total of 12 shovel tests were excavated across the project area. Four historic era archaeological sites (41MR296, 41MR297, 41MR298, and 41MR299) were identified as a result of the survey. All cultural objects recovered from shovel testing, except for modern objects less than 50 years old and excessive numbers of structural materials such as brick and concrete fragments, and all documents associated with this investigation were curated at the Texas Archeological Research Laboratory in Austin, Texas. For the excessive numbers of structural materials, a representative sample will be retained and submitted to TARL for permanent curation. Site 41MR296 has been evaluated as not eligible for inclusion in the NHRP and not worthy of designation as a SAL. Sites 41MR297, 41MR298, and 41MR299 have been determined to be unknown as to eligibility for inclusion in the NRHP or worthy of listing as a SAL. The client has agreed to conduct the proposed construction in such a way as to not impact the three archaeological sites with unknown eligibility. Sphere 3 therefore recommends construction be allowed to proceed without further cultural resource investigations

    Cultural Resources Investigation Report of the Proposed Bear Creek SUD Water System Improvements Project in Lavon, Collin County, Texas

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    Sphere 3 Environmental, Inc. (Sphere 3) conducted an intensive pedestrian cultural resources survey of approximately 5.1 hectares (12.7 acres) of land designated as the Area of Potential Effects (APE) on January 31 through February 1, 2019, in response to water system improvements proposed by Bear Creek Special Utility District (SUD). The project area is located on the east side of Lake Road, the north side of Moore Lane, and both sides of Texas State Highway 78. The facilities tracts and waterline are owned by Bear Creek SUD. The waterline will be owned by Bear Creek SUD. The cultural resources survey was conducted under Texas Antiquities Permit #8745 to identify properties eligible for inclusion in the National Register of Historic Places (NRHP) or listing as a State Antiquities Landmark (SAL). A total of 64 shovel tests were excavated across the project area. Two archaeological localities were identified, Site 41COL316 and Isolated Find #1. Site 41COL316 was identified as a multi-component indeterminate prehistoric and indeterminate historic low-density artifact scatter in a highly disturbed cultivated upland flat terrace. Prehistoric artifacts recovered from the site consisted of five lithic fragments exhibiting minimal cultural modification. Historic artifacts, likely scattered from domestic activities at a nearby residence, consist of two chronologically diagnostic amethyst bottle glass shards. Additional cultural objects collected included: a clam shell fragment, several amber, aqua, and colorless bottle glass fragments evaluated as likely greater than 50 years old, and several iron objects. Recent cultural objects (less than 50 years old) within this scatter include amber bottle fragments with paper beer labels attached thereunto, contemporary store label affixed to lighter, and amber glass shards exhibiting no patina, wear, of other signs of aging and are attributed as discarded materials from the occupants of vehicles traversing the road forming the site’s east boundary. The site’s integrity has been destroyed by many years of use for cultivating row crops since prior to the 1960s. Isolated Find #1 consists of a buried single translucent colorless bottle glass shard, for which site delineation revealed no additional historic cultural association. Project records and artifacts were curated at the Texas Archeological Research Laboratory (TARL) in Austin, Texas. The site and Isolated Find #1 have been evaluated as not eligible for inclusion in the NRHP or for listing as a SAL. Sphere 3 therefore recommends that construction of water system improvements proceed as planned without further cultural resource investigations

    Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

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    BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

    Enzyme Handbook

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