43 research outputs found
Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results
Background: Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory diseases. The advent of biosimilar treatment options such as CT-P13 promises to improve the availability of biological therapy, yet real-world switching data are currently limited. Here, we assess the effectiveness and safety of switching to CT-P13 from infliximab reference product (RP) in patients with inflammatory bowel disease.
Materials and methods: This was a prospective single-center observational study in patients with moderate to severe Crohn’s disease (CD) and ulcerative colitis (UC). All patients were switched from infliximab RP (Remicade) to CT-P13 treatment and followed up for up to 12 months. The efficacy endpoint was the change in clinical response assessed at 3-monthly intervals, according to the Harvey–Bradshaw score and partial Mayo score for patients with CD and UC, respectively. C-reactive protein (CRP) was also measured. Adverse events were monitored and recorded throughout the study.
Results: A total of 98 patients with inflammatory bowel disease (67 CD/31 UC) were included. A total of 83.6% (56/67) of patients with CD were in remission at the time of the switch and 62.7% were in remission at 12 months. The Harvey–Bradshaw score showed a significant change at 12 months (P =0.007) but no significant change was observed in median CRP at this timepoint (P= 0.364). A total of 80.6% (25/31) of patients with UC were in remission at the time of the switch and 65.3% (18/28) were in remission at 12 months. No significant changes in the median partial Mayo score (P=0.058) or CRP (P =0.329) were observed at 12 months. Serious adverse events related to medication were reported in 11 (11.2%) patients.
Conclusion: Switching from infliximab RP to CT-P13 is efficacious and well tolerated in patients with CD or UC for up to 12 months
Risk factors associated with the antimicrobial resistance of staphylococci in canine pyoderma
This study reports the susceptibility to antimicrobial agents of staphylococci
4 (n=105) isolated from dogs, and the factors associated with this resistance. The study
5 animals were 23 healthy dogs (group A), 24 with first-time pyoderma (group B), and 27
6 with recurrent pyoderma that had undergone long-term antibiotic treatment (group C).
7 Staphylococci were more commonly isolated from the pyoderma-affected than the
8 healthy dogs (p<0.0001).
9
10 Some 78% of the isolates were resistant to at least one antimicrobial agent.
11 Resistance to amoxicillin-clavulanate,cephalosporins (OR 4.29, 95% CI [1.15, 16.3]
12 respectively), enrofloxacin (OR 9.47, 95% CI [1.53, 58.5]) and ciprofloxacin (OR 79.7
13 95% CI [3.26, 1947.4]) was more common among group C isolates. Some 32% of all
14 the isolates were multiresistant (MR) and 10.4% were methicillin-resistant (MRS). The
15 probability of isolating MRS staphylococci in group C increased by a factor of four
16 (95% CI [1.18, 17.9]) compared to A plus B. Multi-resistant (MR) isolates were
17 obtained more commonly from urban than rural dogs (OR 3.79, 95% CI [1.09, 13.17]).
18 All the MRS staphylococci encountered were obtained from urban dogs and more
19 commonly from male dogs (p= 0.07).
20
21 This study shows that dogs bred in urban habitat, with a history of antibiotic
22 therapy in the past year represents significant risk of being carriers of isolates resistant
23 to methicillin (MRS) and other antimicrobials. These factors should be considered
24 before applying an antimicrobial treatment in veterinary clinics
Comparison of the Mayo Endoscopy Score and the Ulcerative Colitis Endoscopy Index of Severity and the Ulcerative Colitis Colonoscopy Index of Severity
Background and study aims: Endoscopy plays an essential
role in managing patients with ulcerative colitis (UC),
as it allows us to visualize and assess the severity of the disease.
As such assessments are not always objective, different
scores have been devised to standardize the findings.
The main aim of this study was to assess the interobserver
variability between the Mayo Endoscopy Score (MES), Ulcerative
Colitis Endoscopy Index of Severity (UCEIS) and
Ulcerative Colitis Colonoscopy Index of Severity (UCCIS)
analyzing the severity of the endoscopic lesions in patients
with ulcerative colitis.
Patients and methods: This was a single-cohort observational
study in which a colonoscopy was carried out on patients
with UC, as normal clinical practice, and a video was
recorded. The results from the video were classified according
to the MES, UCEIS and UCCIS by three endoscopic specialists
independently, and they were compared to each
other. The Mayo Endoscopy Score (MES) was used to assess
the clinical situation of the patient. The therapeutic impact
was analyzed after colonoscopy was carried out.
Results: Sixty-seven patients were included in the study.
The average age was 51 (SD ± 16.7) and the average MES
was 3.07 (SD± 2.54). The weighted Kappa index between
endoscopists A and B for the MES was 0.8; between A and
C 0.52; and between B and C 0.49. The intraclass correlation
coefficient for UCEIS was 0.92 among the three endoscopists
(CI 95 %: 0.83–0.96) and 0.96 for UCCIS among the
three endoscopists (CI 95% 0.94–0.97). A change in treatment
for 34.3% of the patients was implemented on seeing
the results of the colonoscopy.
Conclusions: There was an adequate, but not perfect, correlation
between the different endoscopists for MES, UCEIS,
UCCIS. This was higher with the last two scores. Thus, there
is still some subjectivity to be minimized through special
training, on assessing the seriousness of the endoscopic lesions
in patients with UC
Diseño e implementación de un taller de aprendizaje transversal basado en la resolución de problemas en Histología y Anatomía Patológica Veterinarias
Mediante el desarrollo de un taller práctico empleando las técnicas de aprendizaje basado en la resolución de problemas y deducción de pruebas, los alumnos de tres asignaturas diferentes pero relacionadas (Histología Veterinaria, Anatomía Patológica General y Especial), del grado en veterinaria, participaron en su propio proceso de aprendizaje, trabajando en equipo, desarrollando habilidades deductivas y críticas al resolver y analizar supuestos reales, que les ayudarán a estar mejor preparados para su futuro profesional
Lab at home: prácticas de Ingeniería Química en tiempos de confinamiento
En este proyecto de innovación docente se han desarrollado prácticas de laboratorio de dos asignaturas del Grado en Ingeniería Química, Ingeniería Térmica y Operaciones de Separación, para así garantizar la experimentalidad en situaciones de docencia no presencial empleando materiales cotidianos e instalaciones confeccionadas por impresión 3D, que podrán ser empleadas por los estudiantes en situación de confinamiento
Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)
Cases were patients with complicated urinary tract infection (cUTI), complicated intraabdominal (cIAI), pneumonia or bacteraemia from other sources (BSI-OS) due to CRE; control groups were patients with infection caused by carbapenem-susceptible Enterobacterales (CSE), and by non-infected patients, respectively. Matching criteria included type of infection for CSE group, ward and duration of hospital admission. Conditional logistic regression was used to identify risk factors. Findings Overall, 235 CRE case patients, 235 CSE controls and 705 non-infected controls were included. The CRE infections were cUTI (133, 56.7%), pneumonia (44, 18.7%), cIAI and BSI-OS (29, 12.3% each). Carbapenemase genes were found in 228 isolates: OXA-48/like, 112 (47.6%), KPC, 84 (35.7%), and metallo-beta-lactamases, 44 (18.7%); 13 produced two. The risk factors for CRE infection in both type of controls were (adjusted OR for CSE controls; 95% CI; p value) previous colonisation/infection by CRE (6.94; 2.74-15.53; <0.001), urinary catheter (1.78; 1.03-3.07; 0.038) and exposure to broad spectrum antibiotics, as categorical (2.20; 1.25-3.88; 0.006) and time-dependent (1.04 per day; 1.00-1.07; 0.014); chronic renal failure (2.81; 1.40-5.64; 0.004) and admission from home (0.44; 0.23-0.85; 0.014) were significant only for CSE controls. Subgroup analyses provided similar results. Interpretation The main risk factors for CRE infections in hospitals with high incidence included previous coloni-zation, urinary catheter and exposure to broad spectrum antibiotics
5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica
El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería.
En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones.
El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador.
Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores.
Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros
Geodivulgar: Geología y Sociedad
Con el lema “Geología para todos” el proyecto Geodivulgar: Geología y Sociedad apuesta por la divulgación de la Geología a todo tipo de público, incidiendo en la importancia de realizar simultáneamente una acción de integración social entre estudiantes y profesores de centros universitarios, de enseñanza infantil, primaria, de educación especial y un acercamiento con público con diversidad funcional