Editorial introduction to Designing for Play as Cultural Production in Childhood:Seeking new grounds

In 2021 the BIN network (Børneforskere i Norden - [Children’s Culture Researchers in the Nordic Countries]) invited researchers from all over the world to meet in order to explore potential relationships and bridges between two research areas, childhood studies and design, that share an interest in play as a topic of research.The conference invited both practitioners and scholars to participate to empower and enrich a landscape for conversation and development in order for the areas to inspire each other. Over 400 people from all over the world participated in sessions during the two-day conference.Based on the conference, we invited authors to contribute to this special issue of Conjunctions. Transdisciplinary Journal of Cultural Participation with the title Designing for Play as Cultural Participation in Childhood. Seeking new grounds

Editorial introduction to Designing for Play as Cultural Production in Childhood:Seeking new grounds

In 2021 the BIN network (Børneforskere i Norden - [Children’s Culture Researchers in the Nordic Countries]) invited researchers from all over the world to meet in order to explore potential relationships and bridges between two research areas, childhood studies and design, that share an interest in play as a topic of research.The conference invited both practitioners and scholars to participate to empower and enrich a landscape for conversation and development in order for the areas to inspire each other. Over 400 people from all over the world participated in sessions during the two-day conference.Based on the conference, we invited authors to contribute to this special issue of Conjunctions. Transdisciplinary Journal of Cultural Participation with the title Designing for Play as Cultural Participation in Childhood. Seeking new grounds

What determines individuals' preferences for colorectal cancer screening programmes? A discrete choice experiment.

INTRODUCTION: In many countries uptake of colorectal cancer (CRC) screening remains low. AIM: To assess how procedural characteristics of CRC screening programmes determine preferences for participation and how individuals weigh these against the perceived benefits from participation in CRC screening. METHODS: A discrete choice experiment was conducted among subjects in the age group of 50-75 years, including both screening-naive subjects and participants of a CRC screening programme. Subjects were asked on their preferences for aspects of CRC screening programmes using scenarios based on pain, risk of complications, screening location, preparation, duration of procedure, screening interval a

ZAK beta is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle

Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle repair, and hypertrophy. However, the mechanisms by which muscle fibers sense mechanical load to activate this signaling have remained elusive. Here, we show that the upstream MAP3K ZAK beta is activated by cellular compression induced by osmotic shock and cyclic compression in vitro, and muscle contraction in vivo. This function relies on ZAKO's ability to recognize stress fibers in cells and Z-discs in muscle fibers when mechanically perturbed. Consequently, ZAK-deficient mice present with skeletal muscle defects characterized by fibers with centralized nuclei and progressive adaptation towards a slower myosin profile. Our results highlight how cells in general respond to mechanical compressive load and how mechanical forces generated during muscle contraction are translated into MAP kinase signaling.Peer reviewe

Appropriate use of colistin in neonates, infants and children : interim guidance

DATA AVAILABILITY : No raw data are available for this guidance document.No abstract available.http://www.sajid.co.zaam2024Paediatrics and Child HealthSDG-03:Good heatlh and well-bein

Zinc enrichment and isotopic fractionation in a marine habitat of the c. 2.1 Ga Francevillian Group: A signature of zinc utilization by eukaryotes?

Constraining the timing of eukaryogenesis and the divergence of eukaryotic clades is a major challenge in evolutionary biology. Here, we present trace metal concentration and zinc isotope data for c. 2.1 billion-year-old Francevillian Group pyritized structures, previously described as putative remnants of the first colonial multicellular organisms, and their host black shales. Relative to the host rocks, pyritized structures are strongly enriched in zinc, cobalt and nickel, by at least one order of magnitude, with markedly lighter zinc isotope compositions. A metabolic demand for high concentrations of aqueous zinc, cobalt, and nickel combined with preferential uptake of lighter zinc isotopes may indicate metalloenzyme utilization by eukaryotes in marine habitats c. 2.1 billion years ago. Once confirmed, this would provide a critical calibration point for eukaryogenesis, suggesting that this major evolutionary innovation may have happened contemporaneously with elevated atmospheric oxygen levels during the latter part of the Great Oxidation Event, some 400 million years earlier than is currently widely accepted