1,324 research outputs found

    Lexical typology : a programmatic sketch

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    The present paper is an attempt to lay the foundation for Lexical Typology as a new kind of linguistic typology.1 The goal of Lexical Typology is to investigate crosslinguistically significant patterns of interaction between lexicon and grammar

    Qualities, objects, sorts, and other treasures : gold digging in English and Arabic

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    In the present monograph, we will deal with questions of lexical typology in the nominal domain. By the term "lexical typology in the nominal domain", we refer to crosslinguistic regularities in the interaction between (a) those areas of the lexicon whose elements are capable of being used in the construction of "referring phrases" or "terms" and (b) the grammatical patterns in which these elements are involved. In the traditional analyses of a language such as English, such phrases are called "nominal phrases". In the study of the lexical aspects of the relevant domain, however, we will not confine ourselves to the investigation of "nouns" and "pronouns" but intend to take into consideration all those parts of speech which systematically alternate with nouns, either as heads or as modifiers of nominal phrases. In particular, this holds true for adjectives both in English and in other Standard European Languages. It is well known that adjectives are often difficult to distinguish from nouns, or that elements with an overt adjectival marker are used interchangeably with nouns, especially in particular semantic fields such as those denoting MATERIALS or NATlONALlTIES. That is, throughout this work the expression "lexical typology in the nominal domain" should not be interpreted as "a typology of nouns", but, rather, as the cross-linguistic investigation of lexical areas constitutive for "referring phrases" irrespective of how the parts-of-speech system in a specific language is defined

    Scatter factor : molecular characteristics and effect on the invasiveness of epithelial cells

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    The generation of invasiveness in transformed cells represents an essential step of tumor progression. We have previously shown that MDCK epithelial cells, which are deprived of intracellular adhesion by the addition of anti-Arc-1/uvomorulin antibodies, become invasive for collagen gels and embryonal heart tissue (Behrens, J., M. M. Mareel, F. M. Van Roy, and W. Birchmeier. 1989. J. Cell Biol. 108: 2435-2447.). Here we examined whether invasiveness is also induced by scatter factor, which is known to dissociate epithelial cells (Stoker, M., E. Gherardi, M. Perryman, and J. Gray. 1987. Nature (Lond.). 327:239-242.). Scatter factor was purified to homogeneity from conditioned medium of human fibroblasts by heparin-Sepharose chromatography, followed by cation exchange chromatography, gel filtration, or preparative SDS gel electrophoresis. We found that scatter factor represents a 92,000 mol wt glycoprotein which, apparently, is converted by limited proteolysis into disulfide-linked 62,000 and 34/32,000 mol wt subunits. Reversed phase HPLC and sequence analysis of tryptic peptides confirmed the suggested molecular structure, and revealed further that scatter factor exhibits sequence similarities to hepatocyte growth factor and to plasminogen. Purified scatter factor in fact induces the invasiveness into collagen matrices of MDCK epithelial cells, and induces or promotes the invasiveness of a number of human carcinoma cell lines. Apparently, the effect on the human cells depends on their respective degree of differentiation, i.e., cell lines with a less pronounced epithelial phenotype were more susceptible to the factor. Scatter factor does not seem to influence synthesis, steady-state level, and phosphorylation of the cell adhesion molecule Arc-1/uvomorulin. Thus, scatter factor represents a clearly defined molecular species which induces, in vitro, the progression of epithelial cells to a more motile, i.e., invasive phenotype

    Rapid hydrothermal cooling above the axial melt lens at fast-spreading mid-ocean ridge

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    Axial melt lenses sandwiched between the lower oceanic crust and the sheeted dike sequences at fast-spreading mid-ocean ridges are assumed to be the major magma source of oceanic crust accretion. According to the widely discussed "gabbro glacier'' model, the formation of the lower oceanic crust requires efficient cooling of the axial melt lens, leading to partial crystallization and crystal-melt mush subsiding down to lower crust. These processes are believed to be controlled by periodical magma replenishment and hydrothermal circulation above the melt lens. Here we quantify the cooling rate above melt lens using chemical zoning of plagioclase from hornfelsic recrystallized sheeted dikes drilled from the East Pacific at the Integrated Ocean Drilling Program Hole 1256D. Weestimate the cooling rate using a forward modelling approach based on CaAl-NaSi interdiffusion in plagioclase. The results show that cooling from the peak thermal overprint at 1000-10506 degrees C to 6006 degrees C are yielded within about 10-30 years as a result of hydrothermal circulation above melt lens during magma starvation. The estimated rapid hydrothermal cooling explains how the effective heat extraction from melt lens is achieved at fast-spreading mid-ocean ridges.DFG/KO1723/12-1DFG/KO1723/12-

    Betriebliche Restrukturierung und Partizipation: wie viel Teilhabe erlauben unterschiedliche Rationalisierungsansätze?

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    "Rationalisierung in ihren unterschiedlichen Facetten stellt eine wichtige Realität in der Mehrzahl deutscher Betriebe dar. Der vorliegende Beitrag analysiert konkrete Restrukturierungsformen, die mit den Rationalisierungsansätzen „operative Dezentralisierung“ und „strategisches Grenzmanagement“ verbunden sind, und fragt nach deren Bedeutung für die Partizipation des Betriebsrats. Unter Rückgriff auf die Daten der WSI-Betriebsrätebefragung zur betrieblichen Restrukturierung (2006) wird neben der Intensität von Restrukturierung selbst auch die Tiefe der Partizipation des Betriebsrates untersucht. Beim Vergleich zwischen operativer Dezentralisierung und strategischem Grenzmanagement zeigen sich deutliche Unterschiede. So werden Betriebsräte bei Maßnahmen der Dezentralisierung vergleichsweise besser informiert und unterbreiten häufiger eigene Konzeptvorschläge, welche dann auch vermehrt vom Management aufgegriffen werden." (Autorenreferat)"Rationalization in its different forms is an important aspect of life within German establishments. The paper analyzes different restructuring projects which can be associated with the rationalization concepts of “operational decentralization” and “strategic management of boundaries” and discusses their impact on establishment-level codetermination through works councils. The analysis is based on the 2006 WSI-survey of establishment-level restructuring which focuses on the intensity of restructuring as well as on the depth of participation of works councils. The comparison of operational decentralization and strategic management of boundaries reveals important differences. In the case of restructuring projects which are associated with decentralization, works councils proved to be comparatively better informed by management and their own proposals for restructuring were adopted more frequently." (author's abstract

    Effekte veredelter Rohmaterialien angewandt als Dünger oder Wachstumsstimulatoren auf Pflanzenwachstum und -gesundheit

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    In an EU CRAFT project (COOP-CT-2004-508458) running from March 2004 to March 2006, an international consortium of producers of environmentally benign crop inputs, RTD performers and end users, evaluated the production and use of products manu-factured from different raw materials such as seaweeds, pine needles, trees and herbaceous species or physically hydrolysed bovine fur and hair residues. At the field level, the products were applied as solid pellets or liquids, as fertilisers or sprays, respectively. This paper presents as an example results from field trials of organically grown potatoes and tomatoes at the University of Kassel. Assessments were per-formed on yield, plant health and quality aspects. In most of the experiments solid products (pellets) with nitrogen contents between 7 to 12% resulted in comparable growth effects as obtained with hornmeal fertilisers. However, one of the liquid prod-ucts applied as a spray in potatoes increased yield significantly. A combination of the same liquid and a solid product based on plant raw materials reduced plant and fruit late blight in a field trial with open-field tomatoes. It is concluded that especially the combination of well adapted liquid and solid products can have promising effects on crop performance

    Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours

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    The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are β-catenin-binding sites. Each mutation in the MCR leads to the synthesis of a truncated APC product expressed in a colorectal tumour. The MCR extends from the 3′ border of the first 20R coding region to approximately the middle of the third 20R coding region, reflecting both positive and negative selections of the N- and C-terminal halves of the APC protein in colon cancer cells, respectively. In contrast, the second 20R escapes selection and can be either included or excluded from the truncated APC products found in colon cancer cells. To specify the functional outcome of the selection of the mutations, we investigated the β-catenin binding capacity of the first three 20R in N-terminal APC fragments. We found in co-immunoprecipitation and intracellular co-localization experiments that the second 20R is lacking any β-catenin binding activity. Similarly, we also show that the tumour-associated truncations abolish the interaction of β-catenin with the third 20R. Thus, our data provide a functional definition of the MCR: the APC fragments typical of colon cancer are selected for the presence of a single functional 20R, the first one, and are therefore equivalent relative to β-catenin bindin

    Microstructural evolution and mechanical properties of hybrid bevel gears manufactured by tailored forming

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    The production of multi-metal bulk components requires suitable manufacturing technologies. On the example of hybrid bevel gears featuring two different steels at the outer surface and on the inside, the applicability of the novel manufacturing technology of Tailored Forming was investigated. In a first processing step, a semi-finished compound was manufactured by cladding a substrate using a plasma transferred arc welding or a laser hotwire process. The resulting semi-finished workpieces with a metallurgical bond were subsequently near-net shape forged to bevel gears. Using the residual heat after the forging process, a process-integrated heat treatment was carried out directly after forming. For the investigations, the material combinations of 41Cr4 with C22.8 (AISI 5140/AISI 1022M) and X45CrSi9-3 with C22.8 (AISI HNV3/AISI 1022M) were applied. To reveal the influence of the single processing steps on the resulting interface, metallographic examinations, hardness measurements and micro tensile tests were carried out after cladding, forging and process-integrated heat treatment. Due to forging and heat-treatment, recrystallization and grain refinement at the interface and an increase in both, hardness and tensile strength, were observed. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

    Process chain for the manufacture of hybrid bearing bushings

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    The current study presents a novel Tailored Forming process chain developed for the production of hybrid bearing bushings. In a first step, semi-finished products in the form of locally reinforced hollow profiles were produced using a new co-extrusion process. For this purpose, a modular tool concept was developed in which a steel tube made of a case-hardening steel, either C15 (AISI 1015) or 20MnCr5 (AISI 5120), is fed laterally into the tool. Inside the welding chamber, the steel tube is joined with the extruded aluminum alloy EN AW-6082. In the second step, sections from the compound profiles were formed into hybrid bearing bushings by die forging. In order to set the required forming temperatures for each material—aluminum and steel—simultaneously, a tailored heating strategy was developed, which enabled successful die forging of the hybrid workpiece to the desired bearing bushing geometry. Using either of the case-hardening steels in combination with aluminum, this novel process chain made it possible to produce intact hybrid bearing bushings, which showed both macroscopically and microscopically intimate material contact inside the compound zone
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