1,236 research outputs found
General relativity as an effective field theory: The leading quantum corrections
I describe the treatment of gravity as a quantum effective field theory. This
allows a natural separation of the (known) low energy quantum effects from the
(unknown) high energy contributions. Within this framework, gravity is a well
behaved quantum field theory at ordinary energies. In studying the class of
quantum corrections at low energy, the dominant effects at large distance can
be isolated, as these are due to the propagation of the massless particles
(including gravitons) of the theory and are manifested in the
nonlocal/nonanalytic contributions to vertex functions and propagators. These
leading quantum corrections are parameter-free and represent necessary
consequences of quantum gravity. The methodology is illustrated by a
calculation of the leading quantum corrections to the gravitational interaction
of two heavy masses.Comment: 34 pages, Latex, UMHEP-40
Leptonic - and -decays: mass effects, polarization effects and radiative corrections
We calculate the radiative corrections to the unpolarized and the four
polarized spectrum and rate functions in the leptonic decay of a polarized into a polarized electron. The new feature of our calculation is that we
keep the mass of the final state electron finite which is mandatory if one
wants to investigate the threshold region of the decay. Analytical results are
given for the energy spectrum and the polar angle distribution of the final
state electron whose longitudinal and transverse polarization is calculated. We
also provide analytical results on the integrated spectrum functions. We
analyze the limit of our general results and investigate the
quality of the approximation. In the case we
discuss in some detail the role of the anomalous helicity flip
contribution of the final electron which survives the limit. The
results presented in this 0203048 also apply to the leptonic decays of
polarized -leptons for which we provide numerical results.Comment: 39 pages, 11 postscript figures added. Updated version. Four
references added. A few text improvements. Final version to appear in
Phys.Rev.
The BioGRID Interaction Database: 2011 update
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein
interaction data from model organisms and humans
(http://www.thebiogrid.org). BioGRID currently holds 347 966
interactions (170 162 genetic, 177 804 protein) curated from both
high-throughput data sets and individual focused studies, as derived
from over 23 000 publications in the primary literature. Complete
coverage of the entire literature is maintained for budding yeast
(Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe)
and thale cress (Arabidopsis thaliana), and efforts to expand curation
across multiple metazoan species are underway. The BioGRID houses 48
831 human protein interactions that have been curated from 10 247
publications. Current curation drives are focused on particular areas
of biology to enable insights into conserved networks and pathways that
are relevant to human health. The BioGRID 3.0 web interface contains
new search and display features that enable rapid queries across
multiple data types and sources. An automated Interaction Management
System (IMS) is used to prioritize, coordinate and track curation
across international sites and projects. BioGRID provides interaction
data to several model organism databases, resources such as Entrez-Gene
and other interaction meta-databases. The entire BioGRID 3.0 data
collection may be downloaded in multiple file formats, including PSI MI
XML. Source code for BioGRID 3.0 is freely available without any
restrictions
New Approach for Measuring at Future -Factories
It is suggested that the measurements of hadronic invariant mass ()
distributons in the inclusive decays can be
useful in extracting the CKM matrix element . We investigated
hadronic invariant mass distributions within the various theoretical models of
HQET, FAC and chiral lagrangian as well as ACCMM model. It is also emphasized
that the distribution even at the region in the inclusive
are effetive in selecting the events, experimentally viable at
the future asymmetric factories, with better theoretical understandings.Comment: 11 pages not including 1 figur
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
Damaged mitochondria are eliminated by mitophagy, a selective form of autophagy whose dysfunction associates with neurodegenerative diseases. PINK1, PARKIN and p62/SQTMS1 have been shown to regulate mitophagy, leaving hitherto ill-defined the contribution by key players in 'general' autophagy. In basal conditions, a pool of AMBRA1 - an upstream autophagy regulator and a PARKIN interactor - is present at the mitochondria, where its pro-autophagic activity is inhibited by Bcl-2. Here we show that, upon mitophagy induction, AMBRA1 binds the autophagosome adapter LC3 through a LIR (LC3 interacting region) motif, this interaction being crucial for regulating both canonical PARKIN-dependent and -independent mitochondrial clearance. Moreover, forcing AMBRA1 localization to the outer mitochondrial membrane unleashes a massive PARKIN- and p62-independent but LC3-dependent mitophagy. These results highlight a novel role for AMBRA1 as a powerful mitophagy regulator, through both canonical or noncanonical pathways
Generalized Gordon Identities, Hara Theorem and Weak Radiative Hyperon Decays
It is shown that an alternative form of the parity-nonconserving (PNC)
transition electromagnetic current resolves partly a puzzle with the Hara
theorem. New formulation of it has allowed PNC weak radiative hyperon
transitions of the charged hyperons and
revealing hitherto unseen transition
toroid dipole moment.Comment: LaTex, 7 pages, 2 tables added, text also change
Two-point function of strangeness-carrying vector-currents in two-loop Chiral Perturbation Theory
We calculate the correlator between two external vector-currents having the
quantum-numbers of a charged kaon. We give the renormalized expression to two
loops in standard chiral perturbation theory in the isospin limit, which, as a
physical result, is finite and scale-independent. Applications include a low
energy theorem, valid at two loop order, of a flavor breaking combination of
vector current correlators as well as a determination of the phenomenologically
relevant finite -counterterm combination by means of inverse
moment finite energy sum rules. This determination is less sensitive to
isospin-breaking effects than previous attempts.Comment: 24 pages, revtex, 4 figures, 2 tables, revised version, one ref.
adde
Calculation of 1/m^3 terms in the total semileptonic width of D mesons.
We calculate the 1/ corrections in the inclusive semileptonic widths
of mesons. We show that these are due to the novel penguin type operators
that appear at this level in the transition operator. Taking into account the
nonperturbative corrections leads to the predicted value of the semileptonic
width significantly lower than the experimental value. The worsen the
situation or at the very least, within uncertainty, give small contribution. We
indicate possible ways out. It seems most probable that violations of duality
are noticeable in the energy range characteristic to the inclusive decays in
the charm family. Theoretically these deviations are related to divergence of
the high-order terms in the power expansion in the inverse heavy quark mass.Comment: Final version accepted for publication in Physical Review D (19
pages, 5 figures appended as two PS files at the end of the LATEX file
Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature
Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue sarcoma mostly occurring in extraosseous sites. SEF represents a clinically challenging entity especially because no standardized treatment regimens are available. Intraosseous localization is an additional challenge with respect to the therapeutical approach. We report on a 16-year-old patient with SEF of the right proximal tibia. The patient underwent standardized neoadjuvant chemotherapy analogous to the EURAMOS-1 protocol for the treatment of osteosarcoma followed by tumor resection and endoprosthetic reconstruction. Histopathological analysis of the resected tumor showed >90% vital tumor cells suggesting no response to chemotherapy. Therefore, therapy was reassigned to the CWS 2002 High-Risk protocol for the treatment of soft tissue sarcoma. To date (22 months after diagnosis), there is no evidence of relapse or metastasis. Our data suggest that SEF may be resistant to a chemotherapy regimen containing Cisplatin, Doxorubicin, and Methotrexate, which should be considered in planning treatment for patients with SEF
QED Corrections to Neutrino Electron Scattering
We evaluate the O(alpha) QED corrections to the recoil electron energy
spectrum in the process nu_l + e --> nu_l + e (+gamma), where (+gamma)
indicates the possible emission of a photon and l=e, mu or tau. The soft and
hard bremsstrahlung differential cross sections are computed for an arbitrary
value of the photon energy threshold. We also study the O(alpha) QED
corrections to the differential cross section with respect to the total
combined energy of the recoil electron and a possible accompanying photon.
Their difference from the corrections to the electron spectrum is investigated.
We discuss the relevance and applicability of both radiative corrections,
emphasizing their role in the analysis of precise solar neutrino electron
scattering experiments.Comment: 14 pages + 10 figures. Minimal changes, published versio
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