Hypogene speleogenesis within the Central Basin Platform: Karst Porosity in the Yates Field, Pecos County, Texas, U.S.A.

The Yates Unit Oil Field is located on the southeastern tip of the Central Basin Platform in eastern Pecos County, Texas. It produces from Middle Permian strata, primarily the upper San Andres Formation. Locally, the productive upper San Andres Formation is comprised of successively vertically stacked progradational shelf carbonates. Stratigraphically overlying the Yates Field reservoir, the Toborg Field produces from the uppermost Triassic and Cretaceous units. Both fields are bounded on the north and east sides by the Pecos River, which has remained entrenched in its current location since the early Tertiary. As mapped, the top of the San Andres Formation is an unconformity representing erosional topography that does not truly reflect the subsurface structural configuration

Aadi in situ hypoxia monitoring solutions applied in the framework of the eu fp7 project hypox

Peer Reviewe

GAFF-IC: realistic viscosities for isocyanate molecules with a GAFF-based force field

Aliphatic diisocyanates and their derivatives are key liquid components in the industrial processing of polyurethane materials. In particular, for the synthesis of crosslinked polyurethane materials, the higher functionality molecules obtained by reacting three -or more- diisocyanates are of interest. However, despite their widespread application, the relation between molecular structure and macroscopic physical properties, in particular viscosity, is poorly understood in these systems. In this work, we introduce a new force field parameter set, GAFF-IC, based on the widely-used and versatile GAFF force field, meant for accurate predictions of physical properties of isocyanate-based molecular liquids. The new parameters allow to predict the vaporization enthalpies and densities of several isocyanate-based molecules, which are found in excellent agreement with the available experimental data. The effectiveness and transferability of the improved parameters is verified by calculating the viscosities of several isocyanates, isocyanate dimers (uretdiones) and isocyanate trimers (isocyanurates), resulting in accurate viscosity predictions in excellent agreement with experimental values.This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sk lodowska-Curie Grant Agreement no. 642890 (http://thelink-project.eu/) and it was partially supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, and by the project ”Search-ON2: Revitalization of HPC infrastructure of Uminho” (NORTE-07-0162-FEDER-0000869), under the National Strategic Reference Framework, through the European Regional Development Fun

Cryptic Polyketide Synthase Genes in Non-Pathogenic Clostridium SPP

Modular type I polyketide synthases (PKS) produce a vast array of bacterial metabolites with highly diverse biological functions. Notably, all known polyketides were isolated from aerobic bacteria, and yet no example has been reported for strict anaerobes. In this study we explored the diversity and distribution of PKS genes in the genus Clostridium. In addition to comparative genomic analyses combined with predictions of modular type I polyketide synthase (PKS) gene clusters in sequenced genomes of Clostridium spp., a representative selection of other species inhabiting a variety of ecological niches was investigated by PCR screening for PKS genes. Our data reveal that all studied pathogenic Clostridium spp. are devoid of putative PKS genes. In stark contrast, cryptic PKS genes are widespread in genomes of non-pathogenic Clostridium species. According to phylogenetic analyses, the Clostridium PKS genes have unusual and diverse origins. However, reverse transcription quantitative PCR demonstrates that these genes are silent under standard cultivation conditions, explaining why the related metabolites have been overlooked until now. This study presents clostridia as a putative source for novel bioactive polyketides