32 research outputs found
Growth analysis in the potato crop under different irrigation levels
Conduziu-se um experimento na Fazenda São Manoel, localizada em São Manuel, SP, pertencente à Faculdade de Ciências Agronômicas da Universidade Estadual Paulista, com o objetivo de avaliar os efeitos de diferentes lâminas de irrigação no crescimento da cultura da batata (Solanum tuberosum ssp. tuberosum), cultivar Aracy. O ensaio foi instalado em um Latossolo Vermelho-Escuro, textura arenosa, sob uma cobertura de plástico. O delineamento experimental utilizado foi o de blocos ao acaso, com cinco tratamentos, cinco coletas de plantas para fins de análise de crescimento, e quatro repetições. Os tratamentos consistiam em irrigar a batata quando a tensão da água no solo atingia 15, 35, 55, 75 e 1.500 kPa. O aumento nas lâminas de irrigação induz incremento no índice de área foliar, na duração da área foliar, na taxa de crescimento relativo e na taxa assimilatória líquida. _________________________________________________________________________________________ ABSTRACT: An experiment was carried out at Fazenda São Manoel, pertaining to the Faculdade de Ciências Agronômicas of the Universidade Estadual Paulista, São Manuel, SP, Brazil, to evaluate irrigation levels in the potato (Solanum tuberosum ssp. tuberosum) growth, cv. Aracy. This work was installed in a sandy Dark-Red Latosol, under a plastic cover. The experimental design was an entirely randomized block composed by irrigation in the potato plots when the soil water potential has reached 15, 35, 55, 75 and 1,500 kPa, and five plant sampling time with four replicates. It was found that higher irrigation levels led to increase of the leaf area index, leaf area duration, relative growth rate and net assimilation rate
Whole-genome sequencing reveals host factors underlying critical COVID-19
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Impact of a local newspaper campaign on the uptake of the measles mumps and rubella vaccine
Prediction of infant drug exposure through breastfeeding: population PK modeling and simulation of fluoxetine
BACKGROUND: Risks of significant infant drug exposurethrough breastmilk are poorly defined for many drugs, and largescalepopulation data are lacking. We used population pharmacokinetics(PK) modeling to predict fluoxetine exposure levels ofinfants via mother's milk in a simulated population of 1000 motherinfantpairs.METHODS: Using our original data on fluoxetine PK of 25breastfeeding women, a population PK model was developed withNONMEM and parameters, including milk concentrations, wereestimated. An exponential distribution model was used to account forindividual variation. Simulation random and distribution-constrainedassignment of doses, dosing time, feeding intervals and milk volumewas conducted to generate 1000 mother-infant pairs with characteristicssuch as the steady-state serum concentrations (Css) and infantdose relative to the maternal weight-adjusted dose (relative infantdose: RID). Full bioavailability and a conservative point estimate of1-month-old infant CYP2D6 activity to be 20% of the adult value(adjusted by weigth) according to a recent study, were assumed forinfant Css calculations.RESULTS: A linear 2-compartment model was selected as thebest model. Derived parameters, including milk-to-plasma ratios(mean: 0.66; SD: 0.34; range, 0 - 1.1) were consistent with the valuesreported in the literature. The estimated RID was below 10% in >95%of infants. The model predicted median infant-mother Css ratio was0.096 (range 0.035 - 0.25); literature reported mean was 0.07 (range0-0.59). Moreover, the predicted incidence of infant-mother Css ratioof >0.2 was less than 1%.CONCLUSION: Our in silico model prediction is consistent withclinical observations, suggesting that substantial systemic fluoxetineexposure in infants through human milk is rare, but further analysisshould include active metabolites. Our approach may be valid forother drugs. [supported by CIHR and Swiss National Science Foundation(SNSF)]]]>
eng
oai:serval.unil.ch:BIB_64448644E59E
2022-02-19T02:22:49Z
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https://serval.unil.ch/notice/serval:BIB_64448644E59E
Storia linguistica di Venezia
urn:isbn:9788843055128
info:eu-repo/semantics/altIdentifier/isbn/9788843055128
Tomasin, Lorenzo
info:eu-repo/semantics/book
book
2010
ita
oai:serval.unil.ch:BIB_6444B2C2264E
2022-02-19T02:22:49Z
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https://serval.unil.ch/notice/serval:BIB_6444B2C2264E
L'utilisation du laser CO2 dans le cadre d'une consultation de colposcopie
Hohlfeld, P.
De Grandi, P.
info:eu-repo/semantics/article
article
1988
Médecine et Hygiène, vol. 46, pp. 1325-1329
info:eu-repo/semantics/altIdentifier/pissn/0025-6749
fre
oai:serval.unil.ch:BIB_644527E87B99
2022-02-19T02:22:49Z
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https://serval.unil.ch/notice/serval:BIB_644527E87B99
A study on the clinical significance of the who aml subtype inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q chromosomal abnormalities in 6,819 aml cases
Lugthart, S.
Groeschel, S.
Beverloo, H.
Valk, P.
Schanz, U.
Bhola, S.
Vellenga, E.
Kayser, S.
Ossenkoppele, G.
Verhoef, G.
Ferrant, A.
van den Berg-de Ruiter, E.
Ganser, A.
Jotterand, M.
Krauter, J.
Pabst, T.
Schlegelberger, B.
Schlenk, R.
Delwel, R.
Doehner, K.
Loewenberg, B.
Doehner, H.
info:eu-repo/semantics/conferenceObject
inproceedings
2010
15th Annual Meeting of the European Hematology Association, vol. 95, pp. 482
info:eu-repo/semantics/altIdentifier/isbn/0390-6078
eng
oai:serval.unil.ch:BIB_6445291F3B73
2022-02-19T02:22:49Z
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https://serval.unil.ch/notice/serval:BIB_6445291F3B73
Le politique et l’oblitération. Sur la dialectique de l’engagement
Voirol, Olivier
info:eu-repo/semantics/bookPart
incollection
2015
Penser l’engagement, pp. 71-95
Ouelbani, Mélika (ed.)
fre
oai:serval.unil.ch:BIB_63D52E568CD1
2022-02-19T02:22:47Z
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https://serval.unil.ch/notice/serval:BIB_63D52E568CD1
La maladie ulcereuse gastro-duodenale: que reste-t-il des indications chirurgicales? [Gastroduodenal ulcer disease: what surgical indications are left?]
info:eu-repo/semantics/altIdentifier/pmid/2569232
Cuttat, J. F.
Ruchat, P.
Chapuis, G.
info:eu-repo/semantics/article
article
1989-05
Schweizerische Medizinische Wochenschrift, vol. 119, no. 21, pp. 729-30
info:eu-repo/semantics/altIdentifier/pissn/0036-7672
<![CDATA[Between 1976, date of the introduction of anti-H2, and 1987, 716 patients were hospitalized and operated on for ulcer disease in the surgical department of this hospital. The present study shows that 1. the annual number of operations has regressed by some 30%, 2. while the number of gastric ulcers remains constant on the whole, cases of acute duodenal ulcer have diminished by half, 3. cases of chronic, recurrent, or therapy-resistent duodenal ulcer have increased some tenfold (2 out of 78 in 1976 and 14 out of 45 in 1987), 4. the same is true of perforated ulcers (12 out of 78 in 1976 and 10 out of 45 in 1987) and hemorrhages (12 out of 78 and 10 out of 45), 5. surgery for stenosis has remained constant. -Proximal selective vagotomy has been the treatment of choice since 1981 in over 80% of duodenal ulcers. Operative mortality affects only elderly patients undergoing emergency surgery for complicated ulcer (two thirds perforations, one third hemorrhages). It is 2.6%. We thus confirm the reduced role of surgery in the treatment of gastric ulcer, while redefining the present surgical indications
Prediction of Infant Drug Exposure Through Breastfeeding: Population PK Modeling and Simulation of Fluoxetine Exposure.
The likelihood of significant exposure to drugs in infants through breast milk is poorly defined, given the difficulties of conducting pharmacokinetics (PK) studies. Using fluoxetine (FX) as an example, we conducted a proof-of-principle study applying population PK (popPK) modeling and simulation to estimate drug exposure in infants through breast milk. We simulated data for 1,000 mother-infant pairs, assuming conservatively that the FX clearance in an infant is 20% of the allometrically adjusted value in adults. The model-generated estimate of the milk-to-plasma ratio for FX (mean: 0.59) was consistent with those reported in other studies. The median infant-to-mother ratio of FX steady-state plasma concentrations predicted by the simulation was 8.5%. Although the disposition of the active metabolite, norfluoxetine, could not be modeled, popPK-informed simulation may be valid for other drugs, particularly those without active metabolites, thereby providing a practical alternative to conventional PK studies for exposure risk assessment in this population
The divisomal protein DivIB contains multiple epitopes that mediate its recruitment to incipient division sites
Bacterial cytokinesis is orchestrated by an assembly of essential cell division proteins that form a supramolecular structure known as the divisome. DivIB and its orthologue FtsQ are essential members of the divisome in Gram-positive and Gram-negative bacteria respectively. DivIB is a bitopic membrane protein composed of an N-terminal cytoplasmic domain, a single-pass transmembrane domain, and a C-terminal extracytoplasmic region comprised of three separate protein domains. A molecular dissection approach was used to determine which of these domains are essential for recruitment of DivIB to incipient division sites and for its cell division functions. We show that DivIB has three molecular epitopes that mediate its localization to division septa; two epitopes are encoded within the extracytoplasmic region while the third is located in the transmembrane domain. It is proposed that these epitopes represent sites of interaction with other divisomal proteins, and we have used this information to develop a model of the way in which DivIB and FtsQ are integrated into the divisome. Remarkably, two of the three DivIB localization epitopes are dispensable for vegetative cell division; this suggests that the divisome is assembled using a complex network of protein–protein interactions, many of which are redundant and likely to be individually non-essential. © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Ltd
Biological Properties and Response to X-rays of First-generation Transplants of Spontaneous Mammary Carcinomas in C3H Mice
Introduction to a Debate on City-Regions: New Geographies of Governance, Democracy and Social Reproduction
In this introduction to a special Debates and Developments forum on city-regions, we argue that the recent revival of interest in city-regions has been constructed around a rather narrow set of empirical and theoretical issues relating to exchange, interspatial competition and globalization. The 'new' city-regionalism results in a reification of the city-region as an autonomous political agent of the global space economy. We outline an alternative approach to investigating and understanding geographies of city-regionalism, highlighting: a politics of governance and state re-territorialization around the city-region; the role of democracy and citizenship in city-region politics; and tensions around social reproduction and sustainability across the city-region. Copyright (c) 2007 The Authors. Journal Compilation (c) 2007 Joint Editors and Blackwell Publishing Ltd..