Zarządzanie zasobami ludzkimi w wybranych firmach logistycznych – inspirujące praktyki

Obecnie można zaobserwować szereg zmian w organizacjach i ich otoczeniu. Zarządzanie zasobami ludzkimi pozostaje pod ich wpływem. Zmiany te dotyczą również organizacji w branży logistycznej. Dlatego celem artykułu jest zaprezentowanie wyróżniających się praktyk zarządzania zasobami ludzkimi, które mogą stać się inspiracją. Zatem rozważania skupiają się na praktycznym zarządzaniu zasobami ludzkimi. Metodyka badań zasadza się na systematycznym przeglądzie literatury – artykułów opublikowanych w czasopiśmie zajmującym się w pełni tematyką zarządzania ludźmi w Polsce - Zarządzania Zasobami Ludzkimi (lata 2000-2020). Case study zostały zaktualizowane o bieżące informacje

Axillary cerebral perfusion for arch surgery in acute type A dissection under moderate hypothermia

Backgound: Aortic arch surgery is still associated with increased mortality and morbidity especially in acute type A aortic dissection. Adequate brain protection is essential and commonly performed by either antegrade selective perfusion of the brachiocephalic arteries or an interval of profound hypothermic circulatory arrest. We present our experience for open aortic arch repair with continuous antegrade brain perfusion by means of direct cannulation of the right axillary artery, under moderate hypothermia in patients with acute type A aortic dissection. Methods: In, 25 consecutive patients (17 men) with a mean age of 62.6 ± 14.8 years, aortic repair extended to the arch, for acute type A aortic dissection, was performed through a midline sternotomy. The right axillary artery was used for arterial systemic and brain perfusion at a rectal temperature of 25-27 °C. Results: Mean duration of CPB and aortic cross-clamping was 241 ± 55 and 155 ± 72 min, respectively. The mean duration of circulatory arrest of the lower body and brain perfusion was 39.7 (range, 24-55 min). All the patients survived the procedure and all but one were discharged from hospital. One patient had left arm paralysis which he recovered the first postoperative month. There were no other transient or permanent neurologic deficits. A CT scan was performed at discharge for routine postoperative evaluation. There were no local neurovascular complications related to the cannulation site except for one local re-exploration for bleeding. Conclusions: The absence of any major permanent neurologic deficit or any visceral damages in our patients suggests that continuous moderate hypothermic cerebral perfusion, with an interval of circulatory arrest of the lower body, is adequate for acute type A aortic dissection surgery, allowing safe open repair of the distal aortic arc

Luminescence based temperature bio-imaging: Status, challenges, and perspectives

The only way to get thermal images of living organisms without perturbing them is to use luminescent probes with temperature-dependent spectral properties. The acquisition of such thermal images becomes essential to distinguish various states of cells, to monitor thermogenesis, to study cellular activity, and to control hyperthermia therapy. Current efforts are focused on the development and optimization of luminescent reporters such as small molecules, proteins, quantum dots, and lanthanide-doped nanoparticles. However, much less attention is devoted to the methods and technologies that are required to image temperature distribution at both in vitro or in vivo levels. Indeed, rare examples can be found in the scientific literature showing technologies and materials capable of providing reliable 2D thermal images of living organisms. In this review article, examples of 2D luminescence thermometry are presented alongside new possibilities and directions that should be followed to achieve the required level of simplicity and reliability that ensure their future implementation at the clinical level. This review will inspire specialists in chemistry, physics, biology, medicine, and engineering to collaborate with materials scientists to jointly develop novel more accurate temperature probes and enable mapping of temperature with simplified technical mean

Single-Cell Biodetection by Upconverting Microspinners

This is the peer reviewed version of the following article: Ortiz‐Rivero, E., Prorok, K., Skowickł, M., Lu, D., Bednarkiewicz, A., Jaque, D., & Haro‐González, P. (2019). Single‐Cell Biodetection by Upconverting Microspinners. Small, 15(46), 1904154, which has been published in final form at https://doi.org/10.1002/smll.201904154. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsNear-infrared-light-mediated optical tweezing of individual upconverting particles has enabled all-optical single-cell studies, such as intracellular thermal sensing and minimally invasive cytoplasm investigations. Furthermore, the intrinsic optical birefringence of upconverting particles renders them light-driven luminescent spinners with a yet unexplored potential in biomedicine. In this work, the use of upconverting spinners is showcased for the accurate and specific detection of single-cell and single-bacteria attachment events, through real-time monitoring of the spinners rotation velocity of the spinner. The physical mechanisms linking single-attachment to the angular deceleration of upconverting spinners are discussed in detail. Concomitantly, the upconversion emission generated by the spinner is harnessed for simultaneous thermal sensing and thermal control during the attachment event. Results here included demonstrate the potential of upconverting particles for the development of fast, high-sensitivity, and cost-effective systems for single-cell biodetectionThis work was partially supported by the Ministerio de Economía y Competitividad de España (MAT2016‐75362‐C3‐1‐R) and by the Instituto de Salud Carlos III (PI16/00812), by the Comunidad Autónoma de Madrid (B2017/BMD‐3867RENIMCM), and cofinanced by the European Structural and investment fund Additional funding was provided by COST action CM1403. D.L. thanks the Chinese Scholarship Council for financial support. K.P. acknowledges the support from Foundation for Polish Science (FNP) under START program. A.B. acknowledges financial support from NCN OPUS DEC‐2017/27/B/ST7/01255 gran

Laser refrigeration by an Ytterbium-doped NaYF4 microspinner

Thermal control of liquids with high (micrometric) spatial resolution is required for advanced research such as single molecule/cell studies (where temperature is a key factor) or for the development of advanced microfluidic devices (based on the creation of thermal gradients at the microscale). Local and remote heating of liquids is easily achieved by focusing a laser beam with wavelength adjusted to absorption bands of the liquid medium or of the embedded colloidal absorbers. The opposite effect, that is highly localized cooling, is much more difficult to achieve. It requires the use of a refrigerating micro-/nanoparticle which should overcome the intrinsic liquid heating. Remote monitoring of such localized cooling, typically of a few degrees, is even more challenging. In this work, a solution to both problems is provided. Remote cooling in D2O is achieved via anti-Stokes emission by using an optically driven ytterbium-doped NaYF4 microparticle. Simultaneously, the magnitude of cooling is determined by mechanical thermometry based on the analysis of the spinning dynamics of the same NaYF4 microparticle. The angular deceleration of the NaYF4 particle, caused by the cooling-induced increase of medium viscosity, reveals liquid refrigeration by over −6 K below ambient conditionsThis work was supported by the Ministerio de Ciencia e Innovación de España (PID2019-106211RB-I00 and PID2019-105195RA-I00) and by Universidad Autónoma de Madrid and Comunidad Autónoma de Madrid (SI1/PJI/2019-00052). E.O.R gratefully acknowledges the financial support provided by the Spanish Ministerio de Universidades, through the FPU program (FPU19/04803). K.P. acknowledges financial support from NCN, Poland, grant number 2018/31/D/ST5/0132

Dobowy rytm ciśnienia a niedokrwienie mięśnia sercowego w chorobie wieńcowej z prawidłowym i podwyższonym ciśnieniem tętniczym

Wstęp: Brak nocnego spadku ciśnienia jest czynnikiem ryzyka powikłań narządowych nadciśnienia tętniczego. Znaczenie tego zjawiska u osób normotensyjnych jest nieznane. Celem pracy była ocena wpływu braku nocnego spadku ciśnienia na niedokrwienie mięśnia sercowego w chorobie wieńcowej z prawidłowym i podwyższonym ciśnieniem tętniczym. Materiał i metody: Do badania włączono 98 pacjentów z potwierdzoną koronarograficznie chorobą wieńcową. Na podstawie 24-godzinnego automatycznego monitorowania ciśnienia tętniczego wyodrębniono 55 chorych z nadciśnieniem tętniczym (grupa I) i 43 normotensyjnych (grupa II). W każdej z grup znajdowali się chorzy, u których ciśnienie tętnicze w nocy było niższe o co najmniej 10% w stosunku do wartości rejestrowanych w ciągu dnia. Nazwano ich dippers w odróżnieniu od non-dippers — pacjentów bez nocnego spadku ciśnienia. Wszystkim chorym wykonano 24-godzinne monitorowanie EKG metodą Holtera oceniając liczbę epizodów obniżenia odcinka ST, ich charakter oraz rytm dobowy. Wyniki: W grupie I zarejestrowano 172, a w grupie II — 118 przemijających epizodów obniżenia odcinka ST (PEN). W obu grupach około 60% stanowiły epizody nieme. Całkowita liczba PEN w grupach dippers i non-dippers były podobna. Jednak chorzy bez nocnego spadku ciśnienia większość epizodów mieli w nocy, zaś chorzy z zachowanym rytmem dobowym ciśnienia — w ciągu dnia. U non-dippers istotnie częściej rejestrowano nieme PEN. Zależność ta dotyczyła non-dippers z nadciśnieniem oraz normotensyjnych. Wniosek: W chorobie wieńcowej niezależnie od obecności nadciśnienia tętniczego brak nocnego spadku ciśnienia wiąże się z częstszym występowaniem niemego niedokrwienia i modyfikacją dobowej zmienności niedokrwienia