DISCRIMINANT ANALYSIS OF PURIFICATION ON TURMERIC (CURCUMA LONGA LINN) SAMPLES BASED ON PHYTO-PHARMACOGNOSTICAL AND MULTIVARIATE CHEMOMETRIC TECHNIQUE

Objective: To establish an acceptable identification system of various purification effects in context classical based different media on turmeric samples and relates its altering pattern in favor of phyto-pharmacognostical, image processing and multivariate chemometric analysis.Methods: Authenticated turmeric samples purified through different processes by using different media such as cow's urine, panchapllava (five different plants tender leaves), the inflorescence of alambusha (Sphaeranthus indicus, Linn) decoction, water and buttermilk. Resultant samples dried, pulverized and undertaken powder microscopy, image processing, physicochemical and chromatographic fingerprinting (HPTLC). The multivariate chemometric analysis, principal component analysis (PCA) analyzed with help of Unscrambler and image processing in Matlab software.Results: The addition of characters of medias drug with turmeric powders like the crystal of gomutra, pollen grain and starch grain of Alambusha, epidermis, fibre, the crystal of panchapllava. Identify different perceivable colors in variously processed turmeric by analyzing the Lab color space through the Image segmentation. PC1 and PC2 explained (90 + 9) % total variance in score plot of respective purify turmeric samples shown clear grouping in relation to the physicochemical constant. Quantification of curcumin in various treated turmeric samples displayed variation due to additive effect in high-performance thin layer chromatographic profile.Conclusion: This study proved that purification in ayurveda not only refers to the elimination of toxins and unwanted particles but also the transformation in the properties in the primary substance rendering it safe as well as many desired qualities are imbibed in it

EFFICACY OF AYURVEDIC THERAPIES ON PSORIASIS: A REVIEW ON RESEARCHES CONDUCTED AT GUJARAT AYURVED UNIVERSITY, JAMNAGAR

Psoriasis is a chronic disease that has substantial psychological and social impact on a patients life. However the treatment options available in contemporary system of medicine are not much satisfactory. Psoriasis is far more than just a skin disease and is equated to Eka Kushtha in Ayurveda. Various clinical studies have been carried out at different research centers in India on Psoriasis (Eka Kushtha). Present study is aimed to compile such available research works in various departments of two PG institutes under Gujarat Ayurved University. Total 27 completed research works on Psoriasis were found at PG (24) and PhD (3) levels, which revalidated the impact of various Ayurvedic treatment modalities (viz. Shodhana and Shamana). In Shamana therapy maximum drugs were of Vata Kapha Shamaka, Rakta Prasadana, Vishaghna, Kushthaghna and Kandughna etc. properties, which effectively counteract the etio-pathogenesis of Psoriasis. Whereas, in Shodhana therapy maximum times Virechana procedure was carried out. The therapies were found to be significantly effective and clinically safe as no adverse drug reactions were reported during treatment period

A Review on Kanta Loha (Magnetite)

The pharmaceutical branch of Ayurveda, Rasa Shastra goes into great depth regarding how to prepare various metals and minerals for maximum therapeutic benefit. One of the most prominent Rasa Dravyas, Loha (iron) is non-homologous and extremely harmful to the human body. It must be transformed into a homologous form known as Loha Bhasma. Among the Loha, Kanta Loha is considered the best. In this article, the information regarding Kanta Loha, collected from Ayurvedic classics, as well as information regarding magnetite, is also included. The goal of this study was to highlight the Ayurvedic classic references and modern knowledge of Kanta Loha (Magnetite) and its importance. This article contains studies on Kanta Loha that have been published in both index and non-index journals. For acquiring pertinent knowledge, Ayurvedic Samhitas with commentaries and textbooks on Ayurveda and modern medicine are advised. The knowledge on Kanta Loha scattered across Ayurveda has been gathered together for a better understanding of its relevance in the human body through various approaches, as well as its modern elements. According to a critical analysis of these Kanta Lohas, ancient seers administered magnetite in a more acceptable form

Antihyperlipidemic activity of Navaka Guggulu prepared with fresh (Naveena) and old (Purana) Guggulu: A randomized clinical trial

Introduction: Navaka Guggulu is a well-known polyherbal formulation containing Guggulu (Commiphora wightii Arn. Bhandari) as main ingredient. It is effectively used in Medoroga (hyperlipidemia), Sthaulya (obesity), and other Kaphaja roga. In classics, fresh (Naveena) Guggulu is attributed with Brimhana (body mass increasing) effect while old (Purana) with Atilekhana (scrapping). Earlier studies reported that 1-year-old Guggulu possesses better effect on body weight, body mass index, and cardinal symptoms of Medoroga along with significant lipid lowering effect against fresh Guggulu. It infers that old sample of Guggulu is beneficial. Aim: Considering the results of 1-year-old sample, an attempt has been made to evaluate comparative antihyperlipidemic effect of Navaka Guggulu prepared by old (3-year-old-Purana) Guggulu and fresh (Naveena) Guggulu. Materials and Methods: Navaka Guggulu was prepared by freshly collected and 3-year-old samples of Guggulu. Patients who satisfied inclusion criteria of hyperlipidemia were randomly allocated into two groups, namely, A and B and Navaka Guggulu was administrated at a dose of 2 g twice daily with lukewarm water during Prabhata and Nishi kala (1 h before meal) for 8 weeks. Results: Navaka Guggulu prepared from 3-year-old sample exhibited better results in reducing serum cholesterol (8.94%), serum triglycerides (22.76%), and very low-density lipoprotein (VLDL) level (23.10%), wherein Navaka Guggulu prepared from Naveena sample, reduction was found 4.58% in serum cholesterol, 17.26% in serum triglycerides, and 17.76% in VLDL level. Conclusion: Navaka Guggulu prepared from 3-year-old (Purana) sample is better antihyperlipidemic agent against fresh (Naveena) sample

Autoimmune bullous skin disease managed with ayurvedic treatment: A case report

Autoimmune bullous diseases are a group of rare, acquired disorders characterized by overlapping features, resistance to treatment, and potential fatality. They need quick and proper management to avoid fatal complications. Ayurveda is found to provide better relief in some autoimmune disorders. Herein, we report a 40-year-old male of autoimmune bullous skin disorder (Visphoṭaka) who failed to respond to allopathic medicines and was subsequently treated with Ayurvedic medicines and achieved complete remission

Pharmaceutico-Analytical standardization of 60 Puti Abhraka Bhasma

Abhraka  Bhasma comes under Maharasa Varga and after Parada second position hold by Abhraka. From centuries, Acharayas have been using Abhraka  Bhasma incorporated in vast number of formulations. There are so many methods and medias is used for Shodhana,Marana process of Abhraka ,in present study for Abhraka  Shodhana, Godugdha is used as Shodhana media followed by,Dhanyabhraka and for Marana Gomutra is used. Aim: To generate  pharmaceutical and analytical  profile of 60 Puti Abhraka  Bhasma Material & methods:  Abhraka  Shodhana was done by quenching Abharaka in Godugdha  followed by Dhanyabhraka in Kanji later subjected to Puta using Gomutra as liquid media.Physcio- chemical parameters of Bhasma is performed as per API.  Discussion: Different critical aspects of Abhraka Bhasma will be discussed while increasing number of Puta Conclusion: 60 Puti Abhraka Bhasma dull brown in color and passed all the classical and modern parameters.&nbsp

Hepatoprotective evaluation of Arogyavardhini Rasa against paracetamol-induced liver damage in rats

Introduction: Liver is termed as Yakrut in ayurvedic classical literature, is one of the major organs for maintaining homeostasis, and is involved more or less with all the biochemical pathways in the body. Arogyavardhini Rasa (AVR) is one of the widely practicing ayurvedic herbo-mineral formulations in liver disorders. It has been used for the management of diverse types of Jvara (fever), Kushtha (skin disorders), Medoroga (altered lipid profiles associated with obesity), and other Yakrit vikara (liver disorders). In this study, AVR was prepared as per the 13th-century classical text Rasaratna Samuchaya. On the other hand, heavy metals causing toxicity, especially mercury present in this formulation, are an issue of concern. Aim of the Study: Hepatoprotective effects of formulation were evaluated by paracetamol (PCM)-induced liver damage in rats to substantiate the role of metal mineral in the classical AVR formulation. Materials and Methods: Effects of formulation were assessed on serum and liver tissue biochemical parameters and histopathological studies. Results: PCM produced significantly impaired the liver and kidney functions as assessed through an increase in liver and kidney marker enzymes. Arogyavardhini-treated group significantly (P = 0.05) prevented this hepatotoxicity and strongly supported by histopathological examinations that revealed AVR shows the protection of liver tissue from PCM-induced hepatotoxicity. Conclusion: The observation of the present study has stalwartly supported the hepatoprotective action of AVR against PCM-induced hepatotoxicity in rats

Comparative pharmaceutico analytical study of Haratala (orpiment) Shodhana (purification) using different Shodhana media

INTRODUCTION: Haratala is Uprasa mentioned since vedic period. Chemically, it is Arsenic trisulfide and also classified under schedule E1 drug. There are methods and medias used for Shodhana of Haratala. In the present study for Shodhana of Haratala, three Shodhana media have been taken, i.e., Triphala Kwatha, Tila Tail, Kanji. AIM: The aim of the study is to standardize pharmaceutical procedure of Haratala Shodhana in different Shodhana media and developing its comparative analytical profile. MATERIALS AND METHODS: Haratala Shodhana is done in different Shodhana Media, i.e., Triphala Kwatha, Tila Taila and Kanji. Total three batches in each Shodhana media were carried out for standardization. RESULTS AND DISCUSSION: Three hour duration was required for 100 g of Shodhana of Haratala average 2l of liquid media used for Shodhana, analytically there was significant difference in all three samples of Haratala was found, Three media were taken, i.e., Triphala Kwatha, Tila Taila, Kanji and there analytical profile will be generated to find the probable variations in before and after Shodhana. CONCLUSION: All three media were used for Shodhana of Haratala because all liquid medias were easily available for Shodhana and all possess different therapeutic utilities. Although there is a significant difference seen analytically after Shodhana, In X-ray diffraction, maximum number of peaks were found in Triphala Kwatha Shodhit Haratala so this could be used as differentiating factor for better comparison between all three Shodhana media

Kanta Loha Tablet as a Madhumeha hara drug – A single case study

Rasa Shastra which explains a compendium of formulations that act as spectacular remedies for numerous diseases. Metals were used for Deha Vada (for the cure of ailments) and also for Rasayana Karma(Immunity boosting). Loha Bhasma had been using in many formulations from ancient time itself. Kanta Loha, which is superior among Loha can be considered as Magnetite. The Magnetite should contain more than 60% of iron content in it. The incineration process  done according to the reference of classical Rasa Shastra classics. The controversy term “iron overload lead to diabetes” needs to be rechecked by monitoring the results of tests in diabetic patients after medication in the form of Kanta Loha Bhasma. In this article a single case study result showing towards the anti diabetic effect in human subject

Pharmaceutico-analytical Standardization of Katupila Taila; An Ayurvedic Dosage Form from Ethnobotany: Securinega leucopyrus

Katupila - Securinega leucopyrus (willd) Muell. is ethnobotanic medicine, whose leaves are proven to exhibit wound healing property through in vitro, in vivo experimental studies and clinical study along with other properties like anti inflammatory, antioxidant etc. Present study was aimed to develop suitable Ayurvedic dosage form which can value add to ethnic practice and outcomes of recent studies on Katupila by utilizing probable potential of its alternate aria plant part; stem. Six batches of Katupila taila were prepared from decoction and bolus of stem of Katupila heated with Sesame oil in prescribed manner of Snehapaka as per Ayurvedic classics till Madhyam Snehapaka. Organoleptic, physicochemical evaluation, test parameters for evaluation of Snehakalpa as per Ayurvedic Pharmacopeia of India (API) were recorded in triplicate along with chromatographic pattern. Average 934.8 g (93.48% yield) of Katupila Taila was obtained from batch size of, 1 l of Tila Taila with 212 g of Kalka dravya and 4 l of Kwatha of Katupila stem prepared over 3 days with 13 hrs of total duration of actual heating. Mean specific gravity, refractive index, acid value, iodine value, saponification value and Bellier’s turbidity temperature test (BTTT) value were 0.9179, 1.449  2.908 ± 0.0538, 108.075 ± 2.97, 169.66 ± 8.91 and 19.6 ± 0.3 Mean ± SD respectively. Adopted method of Snehapaka for preparation of Katupila Taila can be considered as standard. Observed organoleptic features, range of physicochemical parameters and chromatographic pattern as per API may be considered as analytical standard for Katupila Taila