Sky access versus shading for pedestrian comfort in the hot tropical climate of Jeddah

Many urban studies have been done to demonstrate that urban sprawl is not the right approach in hot climate cities. On the contrary, a compact design is recommended to enhance human thermal comfort. This research aims to clarify the relation between urban morphology and outdoor thermal comfort of Jeddah, Saudi Arabia. The aim is to develop an outstanding future strategic compact morphology that would facilitate a dynamic development of the city. Jeddah city will soon have a subway that is expected to radically change the habits of its inhabitants. Our idea is to consider the main stations of the future metro as nodes, creating more densely inhabited localities and also defining transitional spaces for pedestrian activities. Microclimates generated in and around these activity nodes must be particularly studied to encourage residents and visitors to reclaim a pedestrian life that was clearly noticeable in the old city, but has virtually disappeared in most recent neighborhoods, entirely devoted to automobile transport. Services and facilities around metro nodes should become the transitional thermal comfort areas of the metro station exits. This paper will provide numerical modeling simulations that are used to assess the solar radiation in the urban layout (the old compact area and the modern sprawl area) by the softwarePostprint (published version

Characterization of façade fenestration for energy studies within the “Eixample” urban tissue of Barcelona

This paper explores the possibility of characterising the degree of fenestration of a certain city by studying a limited building sample. For the case study of the Eixample district of Barcelona, window-to-wall ratio (WWR) guiding values are provided and the role of the date of construction and the façade orientation is assessed regarding the opening size. Results indicate that not only average WWR values but also dispersion indicators should be provided to adequately describe façade fenestration. The age of construction has found to be a helpful parameter to approximate representative WWR values of a tissue reducing the uncertainty.Postprint (published version

The use of thermography to highlight the relationship between air and surface temperatures in urban scenes

The correlation between air and surface temperatures is recurrently used as a descriptor of the urban climate within built environments. The aim of this paper is to explore the possibilities of time-lapse thermography to visualize this relationship in time and space. To this end, thermograms are colorized using a relative-to-air temperature scale, instead of the usual absolute one. This approach was tested for two deep urban canyons belonging to cities with different climates. Relative-to-air thermography has two main advantages: it facilitates comparisons between the thermal responses of urban scenes under different climates and makes convective energy exchanges more comprehensive.Peer ReviewedPostprint (author's final draft

Façade design and energy demand: fenestration indexes from an urban Approach

Façade design has significant effects on inner conditions of spaces and also on the energy needs to achieve user’s comfort. In this regard, the proportion of glazed surfaces to opaque ones plays a key role. Although the link between the fenestration ratio and energy demand for a space has been widely addressed in literature, a considerable number of these studies were based on isolated models, disregarding the effect of the urban surroundings. The aim of this paper is to provide insights on the impact of the window-to-wall ratio (WWR) on thermal energy demands taking into consideration a specific urban context. The Eixample district of Barcelona, with Mediterranean temperate climate, has been selected as the case study. Heating and cooling energy needs have been evaluated for a single residential space by means of computer simulations in Design Builder for different positions within the tissue. Results show that, from a thermal point of view, the design of façade openings within an urban context should vary depending on the orientation and the degree of obstruction, as a reflection of the differences in energy balance within the building envelope.Postprint (published version

Characterization of solar access in mediterranean cities: oriented sky factor

The link between city morphology and urban energy consumption, although proved, requires further research. In that sense, the analysis of parameters describing the urban texture may be a useful approach for energy assessment at a city scale. Some geometrical parameters have been used to study urban energy aspects related to the radiative phenomena, such as heat island or even a rough indicator of solar energy availability in locations where direct radiation is not determining. This paper aims to explore the correlation between one of these parameters -the Sky Factor (SF)- and direct solar radiation over facades, as a characterization tool of solar access within an urban context. Barcelona, a Mediterranean city where direct sunlight and the built environment density are deciding factors, has been chosen as case study. At different points of the facade for several urban canyons, SF value and direct solar radiation for different orientations and times of the year have been computed using Heliodon software. Both results have been related one to another and it has been found that, for a specific latitude, it is possible to define a smooth dependence between these parameters, if the orientation is taken into account. This paper shows that, beyond the SF threshold of 0.42, direct solar radiation on the facade reaches an almost asymptotic value for all orientations and times of the year.Postprint (published version

Genome of Herbaspirillum seropedicae Strain SmR1, a Specialized Diazotrophic Endophyte of Tropical Grasses

The molecular mechanisms of plant recognition, colonization, and nutrient exchange between diazotrophic endophytes and plants are scarcely known. Herbaspirillum seropedicae is an endophytic bacterium capable of colonizing intercellular spaces of grasses such as rice and sugar cane. The genome of H. seropedicae strain SmR1 was sequenced and annotated by The Paraná State Genome Programme—GENOPAR. The genome is composed of a circular chromosome of 5,513,887 bp and contains a total of 4,804 genes. The genome sequence revealed that H. seropedicae is a highly versatile microorganism with capacity to metabolize a wide range of carbon and nitrogen sources and with possession of four distinct terminal oxidases. The genome contains a multitude of protein secretion systems, including type I, type II, type III, type V, and type VI secretion systems, and type IV pili, suggesting a high potential to interact with host plants. H. seropedicae is able to synthesize indole acetic acid as reflected by the four IAA biosynthetic pathways present. A gene coding for ACC deaminase, which may be involved in modulating the associated plant ethylene-signaling pathway, is also present. Genes for hemagglutinins/hemolysins/adhesins were found and may play a role in plant cell surface adhesion. These features may endow H. seropedicae with the ability to establish an endophytic life-style in a large number of plant species

EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

AbstractIntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival