The objective of this study was to determine the Basal Energy Expenditure (BEE) of patients with squamous cell carcinoma (SCC) of the esophagus by indirect calorimetry (IC)

Objetivo: O objetivo do presente estudo foi determinar o Gasto Energético Basal (GEB) através da Calorimetria Indireta (CI) em pacientes com carcinoma epidermóide de esôfago (CEE). Métodos: Estudo transversal com 30 pacientes internados com diagnóstico de CEE submetidos à CI antes de iniciar a terapia oncológica. A avaliação nutricional foi realizada a partir de parâmetros antropométricos (Índice de Massa Corporal, Circunferência do Braço, Dobra Cutânea Triciptal, Circunferência Muscular do Braço e Percentual de Perda de Peso), parâmetros bioquímicos (albumina, transferrina e Proteína C Reativa) e bioimpedância tetrapolar. Além disso, foram determinados a capacidade pulmonar e o estadiamento clínico. A CI foi realizada depois de uma noite de jejum. Valores de p < 0,05 foram considerados estatisticamente significativos. Resultados: A média do GEB pela CI foi de 1.421,8 ± 348,2 kcal e pela Equação de Harris e Benedict (EHB) de 1.310,6 ± 215,1 kcal. A EHB subestimou o GEB comparado com a CI (p= 0,014). Foi encontrada diferença significativa no GEB entre os pacientes desnutridos (1.181,7 ± 278,1 kcal) e bem nutridos (1.509,1 ± 334,1 kcal) pelo IMC (p=0,020). Pelo %PP não foram encontradas diferenças significativas entre o GEB dos pacientes com PP significativa e não significativa (p=0,526). Entre os pacientes que apresentavam o percentual de massa magra abaixo do esperado, foi encontrada GEB de 1.408,9 ± 364,3 kcal, enquanto que os que tinham o percentual de massa magra adequado o GEB foi de 1.538,4 ± 97,5 kcal (p=0,550). Não houve associação entre o GEB pela CI e o estadiamento (p=0,255) e o Índice de Tiffeneau (p=0,946). Na associação entre os exames laboratoriais e o GEB pela CI, não foram encontradas associações significativas entre os que tinham alteração e os que não a tinham (p= 0,364, 0,309 e 0,780, respectivamente). Conclusões: O GEB de pacientes com CEE foi subestimado pela EHB sem fator injúria e superestimado pela EHB com fator injúria de 1,3 quando comparado ao GEB medido pela CI.Expenditure (BEE) of patients with squamous cell carcinoma (SCC) of the esophagus by indirect calorimetry (IC). Methods: Cross-sectional study involving 30 patients admitted with a diagnosis of SCC who underwent IC before starting cancer therapy. Nutritional assessment was conducted using anthropometric parameters (body mass index, arm circumference, triceps skinfold thickness, arm muscle circumference and percentage weight loss), biochemical parameters (albumin, transferrin and Creactive protein) and tetrapolar bioimpedance analysis. Additionally, lung capacity and clinical staging were determined. IC was carried out after overnight fasting. P values <0.05 were considered statistically significant. Results: The mean of the BEE for IC and Harris-Benedict equation were 1421.8 ± 348.2 kcal/day and 1310.6 ± 215.1 kcal/day, respectively. The HBE underestimated the BEE when compared with IC (p=0.014). A significant difference was found in the BEE between malnourished (1181.7 ± 278.1 kcal/day) and well-nourished (1509.1 ± 334.1 kcal/day) patients by BMI (p=0.020). In terms of percentage weight loss, no significant difference was found in BEE between patients with significant or non-significant weight loss (p=0.526). BEE for patients presenting with a lower than expected lean body mass was 1408.9 ± 364.3 kcal/day, whereas for those with an adequate lean body mass it was 1538.4 ± 97.5 kcal/day (p=0.550). No association was found between BEE measured by IC and clinical staging (p=0.255) or the Tiffeneau Index (p=0.946). Additionally, when comparing laboratory examinations with BEE measured by IC, no significant association was found between those with and those without alterations (p=0.364, 0.309 and 0.780 respectively). Conclusion: When compared to BEE measured by IC of patients with SCC, it was found that the HBE without injury factor underestimated, whereas the HBE with an injury factor of 1.3 overestimated BEE

The objective of this study was to determine the Basal Energy Expenditure (BEE) of patients with squamous cell carcinoma (SCC) of the esophagus by indirect calorimetry (IC)

Objetivo: O objetivo do presente estudo foi determinar o Gasto Energético Basal (GEB) através da Calorimetria Indireta (CI) em pacientes com carcinoma epidermóide de esôfago (CEE). Métodos: Estudo transversal com 30 pacientes internados com diagnóstico de CEE submetidos à CI antes de iniciar a terapia oncológica. A avaliação nutricional foi realizada a partir de parâmetros antropométricos (Índice de Massa Corporal, Circunferência do Braço, Dobra Cutânea Triciptal, Circunferência Muscular do Braço e Percentual de Perda de Peso), parâmetros bioquímicos (albumina, transferrina e Proteína C Reativa) e bioimpedância tetrapolar. Além disso, foram determinados a capacidade pulmonar e o estadiamento clínico. A CI foi realizada depois de uma noite de jejum. Valores de p < 0,05 foram considerados estatisticamente significativos. Resultados: A média do GEB pela CI foi de 1.421,8 ± 348,2 kcal e pela Equação de Harris e Benedict (EHB) de 1.310,6 ± 215,1 kcal. A EHB subestimou o GEB comparado com a CI (p= 0,014). Foi encontrada diferença significativa no GEB entre os pacientes desnutridos (1.181,7 ± 278,1 kcal) e bem nutridos (1.509,1 ± 334,1 kcal) pelo IMC (p=0,020). Pelo %PP não foram encontradas diferenças significativas entre o GEB dos pacientes com PP significativa e não significativa (p=0,526). Entre os pacientes que apresentavam o percentual de massa magra abaixo do esperado, foi encontrada GEB de 1.408,9 ± 364,3 kcal, enquanto que os que tinham o percentual de massa magra adequado o GEB foi de 1.538,4 ± 97,5 kcal (p=0,550). Não houve associação entre o GEB pela CI e o estadiamento (p=0,255) e o Índice de Tiffeneau (p=0,946). Na associação entre os exames laboratoriais e o GEB pela CI, não foram encontradas associações significativas entre os que tinham alteração e os que não a tinham (p= 0,364, 0,309 e 0,780, respectivamente). Conclusões: O GEB de pacientes com CEE foi subestimado pela EHB sem fator injúria e superestimado pela EHB com fator injúria de 1,3 quando comparado ao GEB medido pela CI.Expenditure (BEE) of patients with squamous cell carcinoma (SCC) of the esophagus by indirect calorimetry (IC). Methods: Cross-sectional study involving 30 patients admitted with a diagnosis of SCC who underwent IC before starting cancer therapy. Nutritional assessment was conducted using anthropometric parameters (body mass index, arm circumference, triceps skinfold thickness, arm muscle circumference and percentage weight loss), biochemical parameters (albumin, transferrin and Creactive protein) and tetrapolar bioimpedance analysis. Additionally, lung capacity and clinical staging were determined. IC was carried out after overnight fasting. P values <0.05 were considered statistically significant. Results: The mean of the BEE for IC and Harris-Benedict equation were 1421.8 ± 348.2 kcal/day and 1310.6 ± 215.1 kcal/day, respectively. The HBE underestimated the BEE when compared with IC (p=0.014). A significant difference was found in the BEE between malnourished (1181.7 ± 278.1 kcal/day) and well-nourished (1509.1 ± 334.1 kcal/day) patients by BMI (p=0.020). In terms of percentage weight loss, no significant difference was found in BEE between patients with significant or non-significant weight loss (p=0.526). BEE for patients presenting with a lower than expected lean body mass was 1408.9 ± 364.3 kcal/day, whereas for those with an adequate lean body mass it was 1538.4 ± 97.5 kcal/day (p=0.550). No association was found between BEE measured by IC and clinical staging (p=0.255) or the Tiffeneau Index (p=0.946). Additionally, when comparing laboratory examinations with BEE measured by IC, no significant association was found between those with and those without alterations (p=0.364, 0.309 and 0.780 respectively). Conclusion: When compared to BEE measured by IC of patients with SCC, it was found that the HBE without injury factor underestimated, whereas the HBE with an injury factor of 1.3 overestimated BEE

Basal Energy Expenditure measured by indirect calorimetry in patients with squamous cell carcinoma of the esophagus

Background: Determination of Basal Energy Expenditure (BEE) is essential for planning nutritional therapy in patients with esophageal cancer. Aims: The objective of this study was to determine BEE through indirect calorimetry (IC) in patients with squamous cell carcinoma of the esophagus (SCC). Methods: Cross-sectional study involving 30 patients admitted with a diagnosis of SCC who underwent IC before starting cancer therapy. The BEE was evaluated using IC and also estimated by means of the Harris-Benedict Equation (HBE). Nutritional assessment was conducted using anthropometric parameters (body mass index, arm circumference, triceps skinfold thickness, arm muscle circumference, and weight loss), biochemical parameters (albumin, transferrin and C-reactive protein) and tetrapolar bioimpedance to assess body composition (fat free mass). Additionally, lung capacity was measured and clinical staging of the cancer established by the TNM method. Results: The mean of the BEE for IC and Harris-Benedict Equation were 1421.8 ± 348.2 kcal/day and 1310.6 ± 215.1 kcal/day, respectively. No association was found between BEE measured by IC and clinical staging (p=0.255) or the Tiffeneau Index (p=0.946). There were no significant associations between BEE measured by IC and altered dosages of transferrin, albumin and C-reactive protein (p=0.364, 0.309 and 0.780 respectively). The factors most associated with BEE were BMI and fat free mass. Conclusion: The BEE of patients with SCC was underestimated when using the HBE, and the result overestimated when incorporating an injury factor with the HBE. Therefore, despite the practical difficulties of implementing IC, its use should be considered