On-sky single-mode fiber coupling measurements at the Large Binocular Telescope

The demonstration of efficient single-mode fiber (SMF) coupling is a key requirement for the development of a compact, ultra-precise radial velocity (RV) spectrograph. iLocater is a next generation instrument for the Large Binocular Telescope (LBT) that uses adaptive optics (AO) to inject starlight into a SMF. In preparation for commissioning iLocater, a prototype SMF injection system was installed and tested at the LBT in the Y-band (0.970-1.065 $\mu$m). This system was designed to verify the capability of the LBT AO system as well as characterize on-sky SMF coupling efficiencies. SMF coupling was measured on stars with variable airmasses, apparent magnitudes, and seeing conditions for six half-nights using the Large Binocular Telescope Interferometer. We present the overall optical and mechanical performance of the SMF injection system, including details of the installation and alignment procedure. A particular emphasis is placed on analyzing the instrument's performance as a function of telescope elevation to inform the final design of the fiber injection system for iLocater.Comment: 11 pages, 7 figure

Vitamin D supplementation in cutaneous malignant melanoma outcome (ViDMe): a randomized controlled trial.

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Interim Analysis of Phase 2 Results for Cemiplimab in Patients with Metastatic Basal Cell Carcinoma (mBCC) who Progressed on or are Intolerant to Hedgehog Inhibitors (HHIs)

Abstract not available

Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

About one-third of people with major depressive disorder (MDD) fail at least two antidepressant drug trials at 1 year. Together with clinical and experimental evidence indicating that the pathophysiology of MDD is multifactorial, this observation underscores the importance of elucidating mechanisms beyond monoaminergic dysregulation that can contribute to the genesis and persistence of MDD. Oxidative stress and neuroinflammation are mechanistically linked to the presence of neurovascular dysfunction with blood-brain barrier (BBB) hyperpermeability in selected neurological disorders, such as stroke, epilepsy, multiple sclerosis, traumatic brain injury, and Alzheimer’s disease. In contrast to other major psychiatric disorders, MDD is frequently comorbid with such neurological disorders and constitutes an independent risk factor for morbidity and mortality in disorders characterized by vascular endothelial dysfunction (cardiovascular disease and diabetes mellitus). Oxidative stress and neuroinflammation are implicated in the neurobiology of MDD. More recent evidence links neurovascular dysfunction with BBB hyperpermeability to MDD without neurological comorbidity. We review this emerging literature and present a theoretical integration between these abnormalities to those involving oxidative stress and neuroinflammation in MDD. We discuss our hypothesis that alterations in endothelial nitric oxide levels and endothelial nitric oxide synthase uncoupling are central mechanistic links in this regard. Understanding the contribution of neurovascular dysfunction with BBB hyperpermeability to the pathophysiology of MDD may help to identify novel therapeutic and preventative approaches

European, National and Transnational Industrial Relations: Visible and Invisible Hands in European and National Wage Setting (short policy report)

This publication constitutes a deliverable of the ENTIRE VIEW project – European, National and Transnational Industrial Relations: Visible and Invisible Hands in European and National Wage Setting. This project has received funding from the European Commission, DG Employment, Social Affairs and Inclusion under Agreement No VS/2018/0017. March 202

European, National and Transnational Industrial Relations: Visible and Invisible Hands in European and National Wage Setting

This publication constitutes a deliverable of the ENTIRE VIEW project – European, National and Transnational Industrial Relations: Visible and Invisible Hands in European and National Wage Setting. This project has received funding from the European Commission, DG Employment, Social Affairs and Inclusion under Agreement No VS/2018/0017. March 202

European, National and Transnational Industrial Relations: Visible and Invisible Hands in European and National Wage Setting

This publication constitutes a deliverable of the ENTIRE VIEW project – European, National and Transnational Industrial Relations: Visible and Invisible Hands in European and National Wage Setting. This project has received funding from the European Commission, DG Employment, Social Affairs and Inclusion under Agreement No VS/2018/0017. March 202

European, National and Transnational Industrial Relations: Visible and Invisible Hands in European and National Wage Setting (final project report))

This publication constitutes a deliverable of the ENTIRE VIEW project – European, National and Transnational Industrial Relations: Visible and Invisible Hands in European and National Wage Setting. This project has received funding from the European Commission, DG Employment, Social Affairs and Inclusion under Agreement No VS/2018/0017. March 202