A significant hardening and rising shape detected in the MeV/GeV nuFnu spectrum from the recently-discovered very-high-energy blazar S4 0954+65 during the bright optical flare in 2015 February

We report on Fermi Large Area Telescope (LAT) and multi-wavelength results on the recently-discovered very-high-energy (VHE, $E>$ 100 GeV) blazar S4 0954+65 ($z=0.368$) during an exceptionally bright optical flare in 2015 February. During the time period (2015 February, 13/14, or MJD 57067) when the MAGIC telescope detected VHE $\gamma$-ray emission from the source, the Fermi-LAT data indicated a significant spectral hardening at GeV energies, with a power-law photon index of $1.8 \pm 0.1$---compared with the 3FGL value (averaged over four years of observation) of $2.34 \pm 0.04$. In contrast, Swift/XRT data showed a softening of the X-ray spectrum, with a photon index of $1.72 \pm 0.08$ (compared with $1.38 \pm 0.03$ averaged during the flare from MJD 57066 to 57077), possibly indicating a modest contribution of synchrotron photons by the highest-energy electrons superposed on the inverse Compton component. Fitting of the quasi-simultaneous ($<1$ day) broadband spectrum with a one-zone synchrotron plus inverse-Compton model revealed that GeV/TeV emission could be produced by inverse-Compton scattering of external photons from the dust torus. We emphasize that a flaring blazar showing high flux of $\gtrsim 1.0 \times 10^{-6}$ photons cm$^{-2}$ s$^{-1}$ ($E>$ 100 MeV) and a hard spectral index of $\Gamma_{\rm GeV} < 2.0$ detected by Fermi-LAT on daily time scales is a promising target for TeV follow-up by ground-based Cherenkov telescopes to discover high-redshift blazars, investigate their temporal variability and spectral features in the VHE band, and also constrain the intensity of the extragalactic background light.Comment: 15 pages, 3 figures, 2 tables. Accepted by PAS

Circulating vitamin D levels and colorectal cancer risk: a meta-analysis and systematic review of case-control and prospective cohort studies

The associations between circulating vitamin D concentrations and total and site-specific colorectal cancer (CRC) incidence have been examined in several epidemiological studies with overall inconclusive findings. The aim of this systematic review and meta-analysis of both case-control and prospective cohort studies was to evaluate the association between CRC and circulating levels of vitamin D. The main exposure and outcome were circulating total 25(OH)D and CRC, respectively, in the overall population (i.e., all subjects). Two reviewers, working independently, screened all the literature available to identify studies that met the inclusion criteria (e.g., case-control or prospective cohort studies, published in English, and excluding non-original papers). Data were pooled by the generic inverse variance method using a random or fixed effect model, as approriate. Heterogeneity was identified using the Cochran's Q-test and quantified by the I2 statistic. Results were stratified by study design, sex, and metabolite of vitamin D. Sensitivity and subgroup analyses were also performed. A total of 28 original studies were included for the quantitative meta-analysis. Meta-analyses comparing the highest vs lowest categories, showed a 39% lower risk between levels of total 25(OH)D and CRC risk (OR (95% CI): 0.61 (0.52; 0.71); 11 studies) in case-control studies; whereas a 20% reduced CRC risk in prospective cohort studies (HR (95% CI): 0.80 (0.66; 0.97); 6 studies). Results in women mirrored main results, whereas results in men were non-significant in both analyses. Our findings support an inverse association between circulating vitamin D levels and CRC risk

A deep survey of short GRB host galaxies over z∼0−2z\sim0-2: implications for offsets, redshifts, and environments

A significant fraction ($\sim$30\%) of well-localized short gamma-ray bursts (sGRBs) lack a coincident host galaxy. This leads to two main scenarios: \textit{i}) that the progenitor system merged outside of the visible light of its host, or \textit{ii}) that the sGRB resided within a faint and distant galaxy that was not detected by follow-up observations. Discriminating between these scenarios has important implications for constraining the formation channels of neutron star mergers, the rate and environments of gravitational wave sources, and the production of heavy elements in the Universe. In this work, we present the results of our observing campaign targeted at 31 sGRBs that lack a putative host galaxy. Our study effectively doubles the sample of well-studied sGRB host galaxies, now totaling 72 events of which $28\%$ lack a coincident host galaxy to deep limits ($r$\,$\gtrsim$\,$26$ or $F110W$\,$\gtrsim$\,$27$ AB mag), and represents the largest homogeneously selected catalog of sGRB offsets to date. We find that 70\% of sub-arcsecond localized sGRBs occur within 10 kpc of their host's nucleus, with a median projected physical offset of $5.6$ kpc. Using this larger population, we discover a redshift evolution in the locations of sGRBs: bursts at low-$z$ occur at $2\times$ larger offsets compared to those at $z$\,$>$\,$0.5$. Furthermore, we find evidence for a sample of hostless sGRBs at $z$\,$\gtrsim$\,$1$ that are indicative of a larger high-$z$ population, further constraining the sGRB redshift distribution and disfavoring log-normal delay time models.Comment: Submitted to MNRAS. 39 pages, 18 Figures, 4 Table

The Sensitivity of HAWC to High-Mass Dark Matter Annihilations

The High Altitude Water Cherenkov (HAWC) observatory is a wide field-of-view detector sensitive to gamma rays of 100 GeV to a few hundred TeV. Located in central Mexico at 19 degrees North latitude and 4100 m above sea level, HAWC will observe gamma rays and cosmic rays with an array of water Cherenkov detectors. The full HAWC array is scheduled to be operational in Spring 2015. In this paper, we study the HAWC sensitivity to the gamma-ray signatures of high-mass (multi- TeV) dark matter annihilation. The HAWC observatory will be sensitive to diverse searches for dark matter annihilation, including annihilation from extended dark matter sources, the diffuse gamma-ray emission from dark matter annihilation, and gamma-ray emission from non-luminous dark matter subhalos. Here we consider the HAWC sensitivity to a subset of these sources, including dwarf galaxies, the M31 galaxy, the Virgo cluster, and the Galactic center. We simulate the HAWC response to gamma rays from these sources in several well-motivated dark matter annihilation channels. If no gamma-ray excess is observed, we show the limits HAWC can place on the dark matter cross-section from these sources. In particular, in the case of dark matter annihilation into gauge bosons, HAWC will be able to detect a narrow range of dark matter masses to cross-sections below thermal. HAWC should also be sensitive to non-thermal cross-sections for masses up to nearly 1000 TeV. The constraints placed by HAWC on the dark matter cross-section from known sources should be competitive with current limits in the mass range where HAWC has similar sensitivity. HAWC can additionally explore higher dark matter masses than are currently constrained.Comment: 15 pages, 4 figures, version to be published in PR

Optical spectroscopy of Blazars for the Cherenkov Telescope Array

Context. Blazars are the most numerous class of High Energy (HE; E about 50 MeV - few 100 GeV) and Very High Energy (VHE; E about 100 GeV - 10 TeV) gamma-ray emitters. As of today, a measured spectroscopic redshift is available for only about 50% of gamma-ray BL Lacs, mainly due to the difficulty of measuring reliable redshifts from their nearly featureless, continuum-dominated optical spectra. The knowledge of the redshift is fundamental for understanding the emission from blazars, for population studies and also for indirect studies of the extragalactic background light and searches for Lorentz invariance violation and axion-like particles using blazars. Aims. This paper is the first of a series of papers which aim to measure the redshift of a sample of blazars likely to be detected with the upcoming Cherenkov Telescope Array (CTA), a ground based gamma-ray observatory. Methods. Monte Carlo simulations were performed to select those hard spectrum gamma-ray blazars detected with the Fermi-LAT telescope still lacking redshift measurements but likely to be detected by CTA in 30 hours of observing time or less. Optical observing campaigns involving deep imaging and spectroscopic observations were organised to efficiently constrain their redshifts. We performed deep medium to high resolution spectroscopy of nineteen blazar optical counterparts using the ESI spectrograph at Keck, the RSS spectrograph at the SALT telescope, and the EFOSC2 spectrograph at the ESO NTT. We searched systematically for spectral features and, when possible, we estimated the contribution of the host galaxy to the total flux. Results. We measured eleven firm spectroscopic redshifts with values ranging from 0.1116 to 0.482. one tentative redshift, three redshift lower limits including one at z > 0.449 and another at z > 0.868. There were four objects found to have featureless spectra.Comment: Accepted by Astronomy & Astrophysic

Total dairy consumption in relation to overweight and obesity in children and adolescents: A systematic review and meta-analysis

A systematic review and meta-analysis of cross-sectional and prospective cohort studies was conducted to assess the associations between total dairy consumption and its different subtypes with the prevalence and incidence of overweight, obesity, and overweight/obesity in children and adolescents. A literature search was conducted in Medline through PUBMED and Cochrane Library databases until October 18, 2021. Articles reporting the risk estimates as odd ratios (OR), risk ratios (RR), or hazard ratios and their corresponding 95% confidence interval (CI) for the association between dairy product consumption and the risk of overweight and/or obesity were included. In the meta-analysis from cross-sectional studies, results showed an inverse association between total dairy consumption and obesity prevalence (OR (95% CI): 0.66 (0.48–0.91). No significant associations were found between milk or yogurt and obesity prevalence risk. Regarding prospective studies, total milk consumption was positively associated with overweight prevalence (OR (95% CI): 1.13 (1.01–1.26)) and incidence (RR (95%CI): 1.17 (1.01–1.35)) risk. Evidence from pooled analysis of cross-sectional studies suggested an inverse association between total dairy consumption and obesity. However, there is limited and no conclusive evidence to confirm an inverse relationship from pooled analysis of prospective studies in children and adolescents

VAMOS: a Pathfinder for the HAWC Gamma-Ray Observatory

VAMOS was a prototype detector built in 2011 at an altitude of 4100m a.s.l. in the state of Puebla, Mexico. The aim of VAMOS was to finalize the design, construction techniques and data acquisition system of the HAWC observatory. HAWC is an air-shower array currently under construction at the same site of VAMOS with the purpose to study the TeV sky. The VAMOS setup included six water Cherenkov detectors and two different data acquisition systems. It was in operation between October 2011 and May 2012 with an average live time of 30%. Besides the scientific verification purposes, the eight months of data were used to obtain the results presented in this paper: the detector response to the Forbush decrease of March 2012, and the analysis of possible emission, at energies above 30 GeV, for long gamma-ray bursts GRB111016B and GRB120328B.Comment: Accepted for pubblication in Astroparticle Physics Journal (20 pages, 10 figures). Corresponding authors: A.Marinelli and D.Zaboro

The major upgrade of the MAGIC telescopes, Part II: A performance study using observations of the Crab Nebula

MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes located in the Canary island of La Palma, Spain. During summer 2011 and 2012 it underwent a series of upgrades, involving the exchange of the MAGIC-I camera and its trigger system, as well as the upgrade of the readout system of both telescopes. We use observations of the Crab Nebula taken at low and medium zenith angles to assess the key performance parameters of the MAGIC stereo system. For low zenith angle observations, the standard trigger threshold of the MAGIC telescopes is ~50GeV. The integral sensitivity for point-like sources with Crab Nebula-like spectrum above 220GeV is (0.66+/-0.03)% of Crab Nebula flux in 50 h of observations. The angular resolution, defined as the sigma of a 2-dimensional Gaussian distribution, at those energies is < 0.07 degree, while the energy resolution is 16%. We also re-evaluate the effect of the systematic uncertainty on the data taken with the MAGIC telescopes after the upgrade. We estimate that the systematic uncertainties can be divided in the following components: < 15% in energy scale, 11-18% in flux normalization and +/-0.15 for the energy spectrum power-law slope.Comment: 21 pages, 25 figures, accepted for publication in Astroparticle Physic