Room-temperature quantum optomechanics using an ultra-low noise cavity

Ponderomotive squeezing of light, where a mechanical oscillator creates quantum correlations between the phase and amplitude of the interacting light field, is a canonical signature of the quantum regime of optomechanics. At room temperature, this has only been reached in pioneering experiments where an optical restoring force controls the oscillator stiffness, akin to the vibrational motion of atoms in an optical lattice. These include both levitated nanoparticles and optically-trapped cantilevers. Recent advances in engineered mechanical resonators, where the restoring force is provided by material rigidity rather than an external optical potential, have realized ultra-high quality factors (Q) by exploiting `soft clamping'. However entering the quantum regime with such resonators, has so far been prevented by optical cavity frequency fluctuations and thermal intermodulation noise. Here, we overcome this challenge and demonstrate optomechanical squeezing at room temperature in a phononic-engineered membrane-in-the-middle system. By using a high finesse cavity whose mirrors are patterned with phononic crystal structures, we reduce cavity frequency noise by more than 700-fold. In this ultra-low noise cavity, we introduce a silicon nitride membrane oscillator whose density is modulated by silicon nano-pillars, yielding both high thermal conductance and a localized mechanical mode with Q of 1.8e8. These advances enable operation within a factor of 2.5 of the Heisenberg limit, leading to squeezing of the probing field by 1.09 dB below the vacuum fluctuations. Moreover, the long thermal decoherence time of the membrane oscillator (more than 30 vibrational periods) allows us to obtain conditional displaced thermal states of motion with an occupation of 0.97 phonon, using a multimode Kalman filter. Our work extends quantum control of engineered macroscopic oscillators to room temperature

Clamp-tapering increases the quality factor of stressed nanobeams

Stressed nanomechanical resonators are known to have exceptionally high quality factors ($Q$) due to the dilution of intrinsic dissipation by stress. Typically, the amount of dissipation dilution and thus the resonator $Q$ is limited by the high mode curvature region near the clamps. Here we study the effect of clamp geometry on the $Q$ of nanobeams made of high-stress $\mathrm{Si_3N_4}$. We find that tapering the beam near the clamp - and locally increasing the stress - leads to increased $Q$ of MHz-frequency low order modes due to enhanced dissipation dilution. Contrary to recent studies of tethered-membrane resonators, we find that widening the clamps leads to decreased $Q$ despite increased stress in the beam bulk. The tapered-clamping approach has practical advantages compared to the recently developed "soft-clamping" technique. Tapered-clamping enhances the $Q$ of the fundamental mode and can be implemented without increasing the device size

Prometeu contra Hermes: o lugar do design no imaginário contemporâneo

This article proposes a reflection on the contemporary imaginary, taking the design as a central vector and two mythical figures, Hermes and Prometeu, as main coordinates. First, we make some considerations about the theoretical bases that support the approach proposed here, and then we indicate the way in which the figures of Prometeu and Hermes lead much of the sociocultural dynamics. Next, we analyze the post-Promethean paradigm that Bruno Latour identifies from five connotations of the term design. We conclude, finally, that the myths of Hermes and Prometheus are implied in each other and that the design expresses, in the contemporary imaginary, this correlation.Este artigo propõe uma reflexão sobre o imaginário contemporâneo, tomando o design como vetor central e duas figuras míticas, Hermes e Prometeu, como coordenadas principais. De início, tecemos algumas considerações acerca dasbases teóricas que amparam a abordagem aqui proposta e, em seguida, indicamos o modo como as figuras de Prometeu e Hermes conduzem boa parte da dinâmica sociocultural. Na sequência, analisamos o paradigma pós-prometeico que BrunoLatour identifica a partir de cinco conotações do termo design. Concluímos, por fim, que os mitos de Hermes e Prometeu se encontram implicados um no outro e que o design expressa, no imaginário contemporâneo, essa correlação

Thermal intermodulation noise in cavity-based measurements

Thermal frequency fluctuations in optical cavities limit the sensitivity of precision experiments ranging from gravitational wave observatories to optical atomic clocks. Conventional modeling of these noises assumes a linear response of the optical field to the fluctuations of cavity frequency. Fundamentally, however, this response is nonlinear. Here we show that nonlinearly transduced thermal fluctuations of cavity frequency can dominate the broadband noise in photodetection, even when the magnitude of fluctuations is much smaller than the cavity linewidth. We term this noise "thermal intermodulation noise" and show that for a resonant laser probe it manifests as intensity fluctuations. We report and characterize thermal intermodulation noise in an optomechanical cavity, where the frequency fluctuations are caused by mechanical Brownian motion, and find excellent agreement with our developed theoretical model. We demonstrate that the effect is particularly relevant to quantum optomechanics: using a phononic crystal $Si_3N_4$ membrane with a low mass, soft-clamped mechanical mode we are able to operate in the regime where measurement quantum backaction contributes as much force noise as the thermal environment does. However, in the presence of intermodulation noise, quantum signatures of measurement are not revealed in direct photodetectors. The reported noise mechanism, while studied for an optomechanical system, can exist in any optical cavity

Hierarchical tensile structures with ultralow mechanical dissipation

Structural hierarchy is found in myriad biological systems and has improved man-made structures ranging from the Eiffel tower to optical cavities. Hierarchical metamaterials utilize structure at multiple size scales to realize new and highly desirable properties which can be strikingly different from those of the constituent materials. In mechanical resonators whose rigidity is provided by static tension, structural hierarchy can reduce the dissipation of the fundamental mode to ultralow levels due to an unconventional form of soft clamping. Here, we apply hierarchical design to silicon nitride nanomechanical resonators and realize binary tree-shaped resonators with quality factors as high as $10^9$ at 107 kHz frequency, reaching the parameter regime of levitated particles. The resonators' thermal-noise-limited force sensitivities reach $740\ \mathrm{zN/\sqrt{Hz}}$ at room temperature and $\mathrm{90\ zN/\sqrt{Hz}}$ at 6 K, surpassing state-of-the-art cantilevers currently used for force microscopy. We also find that the self-similar structure of binary tree resonators results in fractional spectral dimensions, which is characteristic of fractal geometries. Moreover, we show that the hierarchical design principles can be extended to 2D trampoline membranes, and we fabricate ultralow dissipation membranes suitable for interferometric position measurements in Fabry-P\'erot cavities. Hierarchical nanomechanical resonators open new avenues in force sensing, signal transduction and quantum optomechanics, where low dissipation is paramount and operation with the fundamental mode is often advantageous.Comment: 19 pages, 11 figures. Fixed link to Zenodo repositor

DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action

During the COVID-19 pandemic, drug repurposing represented an effective strategy to obtain quick answers to medical emergencies. Based on previous data on methotrexate (MTX), we evaluated the anti-viral activity of several DHFR inhibitors in two cell lines. We observed that this class of compounds showed a significant influence on the virus-induced cytopathic effect (CPE) partly attributed to the intrinsic anti-metabolic activity of these drugs, but also to a specific anti-viral function. To elucidate the molecular mechanisms, we took advantage of our EXSCALATE platform for in-silico molecular modelling and further validated the influence of these inhibitors on nsp13 and viral entry. Interestingly, pralatrexate and trimetrexate showed superior effects in counteracting the viral infection compared to other DHFR inhibitors. Our results indicate that their higher activity is due to their polypharmacological and pleiotropic profile. These compounds can thus potentially give a clinical advantage in the management of SARS-CoV-2 infection in patients already treated with this class of drugs