Red Europe Versus No Europe? The impact of attitudes towards the EU and the economic crisis on radical-left voting

The 2014 European Parliament election saw a relatively large increase in the size of radical left parties (RLPs), particularly in Western Europe. This article aims to provide new ways of thinking about the dynamics of radical-left voting by analyzing the changing role of attitudes towards the European Union (EU) in explaining support for RLPs at European Parliament elections during the Great Recession. It is argued that the Europeanization of economic issues during the financial crisis, together with the particular kind of Euroscepticism advocated by these parties, have enabled them to successfully attract a heterogeneous pool of voters. Using the 2009 and 2014 European Elections Studies, it is shown that the effect of negative opinions about the EU on radical-left voting increased significantly during the crisis. In addition, support for RLPs also increased among voters with positive views of the EU who were nevertheless strongly dissatisfied with the economic situation

Weathering the crisis: Evidence of diffuse support for the EU from a six-wave Dutch panel

Political regimes draw legitimacy from diffuse political support. How diffuse is support for the European Union? By focusing on cross-sectional data, the extant literature fails to demonstrate that support for the European Union displays the key defining characteristic of diffuse support: individual-level stability over a time of crisis. I use a six-wave panel data set from the Netherlands to study stability in support for the European Parliament during the 2008 economic crisis. I argue that public support for the European Parliament is highly diffuse. Using three analytical techniques, I find that individual-level support for the European Parliament remained highly stable from 2007 to 2012. These results suggest that in times of crisis, the European Union can draw on mass public support as a source of resilience

Impact of Vutrisiran on Quality of Life and Physical Function in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy

INTRODUCTION: Hereditary transthyretin (ATTRv; v for variant) amyloidosis, also known as hATTR amyloidosis, is a progressive and fatal disease associated with rapid deterioration of physical function and patients' quality of life (QOL). Vutrisiran, a subcutaneously administered RNA interference (RNAi) therapeutic that reduces hepatic production of transthyretin, was assessed in patients with ATTRv amyloidosis with polyneuropathy in the pivotal HELIOS-A study. METHODS: The phase 3 open-label HELIOS-A study investigated the efficacy and safety of vutrisiran in patients with ATTRv amyloidosis with polyneuropathy, compared with an external placebo group from the APOLLO study of the RNAi therapeutic patisiran. Measures of QOL and physical function were assessed. RESULTS: At month 18, vutrisiran improved Norfolk Quality of Life-Diabetic Neuropathy (Norfolk QOL-DN) total score (least squares mean difference [LSMD] in change from baseline [CFB]: –21.0; p = 1.84 × 10–10) and Norfolk QOL-DN domain scores, compared with external placebo. This benefit relative to external placebo was evident across all baseline polyneuropathy disability (PND) scores and most pronounced in patients with baseline PND scores I–II. Compared with external placebo, vutrisiran also demonstrated benefit in EuroQoL-Visual Analog Scale (EQ-VAS) score (LSMD in CFB: 13.7; nominal p = 2.21 × 10–7), 10-m walk test (LSMD in CFB: 0.239 m/s; p = 1.21 × 10–7), Rasch-built Overall Disability Score (LSMD in CFB: 8.4; p = 3.54 × 10–15), and modified body mass index (mBMI) (LSMD in CFB: 140.7; p = 4.16 × 10–15) at month 18. Overall, Norfolk QOL-DN, EQ-VAS, and mBMI improved from pretreatment baseline with vutrisiran, whereas all measures worsened from baseline in the external placebo group. At month 18, Karnofsky Performance Status was stable/improved from baseline in 58.2/13.1% with vutrisiran versus 34.7/8.1% with external placebo. CONCLUSION: Vutrisiran treatment provided significant clinical benefits in multiple measures of QOL and physical function in patients with ATTRv amyloidosis with polyneuropathy. Benefits were most pronounced in patients with earlier-stage disease, highlighting the importance of early diagnosis and treatment

Early detection of skin and cardiac amyloid deposits among asymptomatic carriers of hereditary pathogenic transthyretin mutation with normal electroneuromyography

International audienc

Hijacking Europe: Counter‐European Strategies and Radical Right Mainstreaming during the Humanitarian Crisis Debate 2015–16*

Radical right European contestation is analyzed mainly as claims denouncing European integration. Less focus is put on narratives suggesting how a supposed 'truly European' political process should be and work. This paper explores how radical right actors use such counter-European claims within their competition strategies. Computer-assisted qualitative analysis of communication by Front National, Alternative for Germany and Fidesz during the humanitarian crisis debate 2015-16 demonstrates that radical right counter-Europeanism constitutes a nuanced tactical resource deployed to normalize nativist supply in the name of Europe. Unlike Eurorejectionist FN, Fidesz and AfD redefined Europe in nativist terms, attempting to draw legitimacy from association with European identity and cooperation. Concurrently, both actors justified Euronativism not only as antithetical to current EU values and political principles, but mainly as their more fundamental practice juxtaposed against 'not (truly) European elites', effectively 'hijacking' Europe from within. The findings deepen our understanding of radical right Europe-contesting competition strategies

Protecting Us, Protecting Europe? Public Concern about Immigration and Declining Support for European Integration in Italy

This article investigates the effect of immigration on attitudes towards Europe in Italy. This question resonates throughout the European Union (EU), but does so particularly in Italy – one of EU's most exposed external borders, especially under recent global challenges such as the economic crisis and the Arab Spring. Over the last two decades, Italy received more than four million migrants and refugees, which has put immigration on top of the political agenda ever since. Using data from the European Values Study (EVS), we find that concerns about immigration, especially in the context of the economic crisis of 2007, is a factor of declining support for European integration and that these effects vary across regions. In particular, we demonstrate the mediating effect of context by showing that the effect of being concerned about immigration is more corrosive for support in regions with higher immigration rates than in regions with lower rates

Motor unit number index as an individual biomarker: Reference limits of intra-individual variability over time in healthy subjects.

Motor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our objective is to determine the intra-individual variability over time of the MUNIX. In 11 different hospital centres, MUNIX was assessed twice, at least 3 months apart (range 90-360 days), in tibialis anterior (TA), abductor pollicis brevis (APB), abductor digiti minimi (ADM) and deltoid muscles in 118 healthy subjects. MUNIX sum score 2, 3 and 4 were respectively the sum of the MUNIX of the TA and ADM, of the TA, APB and ADM and of the TA, APB, ADM and deltoid muscles. The repeatability of the MUNIX was better for sum scores than for single muscle recordings. The variability of the MUNIX was independent of sex, age, interval between measurements and was lower for experienced than non-experienced operators. The 95th percentile of the coefficient of variability of the MUNIX sum score 2, 3 and 4 were respectively 22%, 18% and 15% for experienced operators. The MUNIX technique must be performed by experienced operators on several muscles to reduce its variability and improve its reliability. A variation of the MUNIX sum score ≥20% can be interpreted as a significant change of muscle innervation