Misreading Jane Eyre: a postformalist paradigm

(print) xvi, 259 p. ; 23 cmAcknowledgments, pg. ix -- PRELIMINARIES -- On Postformalism, pg. xi -- PART I -- Intertextualities, pg. l -- 1. Species and Scenes : Fictional Autobiography and the Confined Child, pg. 11 -- 2. Reality and Narratability : Dothegirls Hall and Child-Deaths, pg. 33 -- 3. Dialogic Genres : The Governess and the Ghost, pg. 46 -- 4. The Transgeneric Topic, Love : A Tale of Incident, Fire, and Feeling, pg. 77 -- PART II -- Strategies of the Text, pg. 101 -- 5. Hybridization : The Three Voices of Jane, pg. 109 -- 6. Devastation and Revisitations : A Cold, Solitary Girl Again, pg. 134 -- 7. Ideology and the Act of Reading : The Cold Cumbrous Column, pg. 168 -- 8. Decentering the Narrator : St. John's Way, pg. 196 -- AFTERWORD -- Decentering the Author : Charlotte Bronte's Misreading of Jane Eyre, pg. 213 -- NOTES, pg. 223 -- BIBLIOGRAPHY, pg. 239 -- INDEX, pg. 25

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

RATIONALE: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known.OBJECTIVES: Perform meta-analyses of GWAS for airflow obstruction, a key pathophysiologic characteristic of COPD assessed by spirometry, in population-based cohorts examining all participants, ever smokers, never smokers, asthma-free participants, and more severe cases.METHODS: Fifteen cohorts were studied for discovery (3,368 affected; 29,507 unaffected), and a population-based family study and a meta-analysis of case-control studies were used for replication and regional follow-up (3,837 cases; 4,479 control subjects). Airflow obstruction was defined as FEV(1) and its ratio to FVC (FEV(1)/FVC) both less than their respective lower limits of normal as determined by published reference equations.MEASUREMENTS AND MAIN RESULTS: The discovery meta-analyses identified one region on chromosome 15q25.1 meeting genome-wide significance in ever smokers that includes AGPHD1, IREB2, and CHRNA5/CHRNA3 genes. The region was also modestly associated among never smokers. Gene expression studies confirmed the presence of CHRNA5/3 in lung, airway smooth muscle, and bronchial epithelial cells. A single-nucleotide polymorphism in HTR4, a gene previously related to FEV(1)/FVC, achieved genome-wide statistical significance in combined meta-analysis. Top single-nucleotide polymorphisms in ADAM19, RARB, PPAP2B, and ADAMTS19 were nominally replicated in the COPD meta-analysis.CONCLUSIONS: These results suggest an important role for the CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be independent of smoking and implicate the HTR4 gene in the etiology of airflow obstruction.</p

The Norton introduction to literature

xxxiv, 2218 p. ; ill. : 25 cm

The Norton introduction to literature. Vol.I

1 CD-ROM ; 4 3/4 in

The Norton introduction to literature

xxxiv, 2218 p. ; ill. : 25 cm

The Norton introduction to literature

xxxiv, 2218 p. ; ill. : 25 cm

Introduction to literature

xxxi, 1782, 121 p. ; 24 cm

The Norton introduction to literature. Vol.II

1 CD-ROM ; 4 3/4 in

The Norton introduction to literature

xxxiv, 2218, 140 p. : ill. ; 24 cm + 1 CD (4 3/4 in)