Timing of proper introduction, optimization and maintenance of anti-TNF therapy in IBD: Results from a Delphi consensus

Background: Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBDs) with a rapidly growing worldwide incidence. The last decades presented rapid progress in pharmacological treatment leading in many cases to clinical and endoscopic remission, including biological treatment with anti-TNF agents. Aim: The exact timing of introduction, optimization and maintenance of anti-TNF therapy in IBDs is not thoroughly covered in current guidelines. Methods: We used the Delphi panel methodology to gather the IBD experts' views and achieve consensus for clinical recommendations on introducing and maintaining anti-TNF therapy for patients with IBDs. Results: Twelve recommendations achieved a high level of consensus in two assessment rounds by 52 (1st round) and 47 (2nd round) IBD experts. Conclusion: In many clinical situations, the early use of anti-TNF therapy is recommended. Nowadays, the cost-efficacy profile of anti-TNF biosimilars makes them the first-line drug in a substantial proportion of patients, thus providing the opportunity to increase access to biological therapy

Litografia Bulla. Un viaggio di duecento anni fra arte e tecnica (Treccani, La Cultura Italiana)

Catalogo della mostra "Litografia Bulla. Un viaggio di duecento anni fra arte e tecnica" (Roma, Palazzo Poli - Istituto centrale per la grafica, 20/04/2018-01/07/2018), edito da Treccani La Cultura Italiana in italiano e in inglese, a cura di Claudio Zambianchi con Flaminia Bulla, Marta Maria Caudullo, Federica De Giambattista, Giulia Papale, Francesca Petito, Patrizia Principi, Eva Scurto, Marta Variali e con Beatrice Bull

Histopathology of non-IBD colitis practical recommendations from pathologists of IG-IBD Group

Pathologists are often called upon to diagnose colitides that differ from the two main forms of inflammatory bowel disease (IBD). These non-IBD colitides include infectious colitis, microscopic colitis, ischemic colitis, eosinophilic colitis, autoimmune enterocolitis, segmental colitis associated with diverticulosis, drug-induced colitis, radiation colitis and diversion colitis. The diagnosis of these different disease entities relies on the histopathological examination of endoscopic biopsies of the gastrointestinal tract. This paper reviews the main histomorphological characteristics of the various Non-IBD colitides. (c) 2021 Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l

Genotype frequencies with significant differences in the selected SNPs between controls and children with bacteriologically confirmed (BC) sepsis.^a

a<p>The sums may not add up to the total because of some missing values. HWE: Hardy-Weinberg equilibrium.</p>b<p>p-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.</p

Genotype frequencies with significant differences in the selected SNPs between children with non-severe and those with severe sepsis.^a

a<p>The sums may not add up to the total because of some missing values. HWE: Hardy-Weinberg equilibrium.</p>b<p>p-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.</p

Genotype frequencies with significant differences in the selected SNPs between controls and children with sepsis.^a

a<p>The sums may not add up to the total because of some missing values. HWE: Hardy-Weinberg equilibrium.</p>b<p>p-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing.</p

Gene and single nucleotide polymorphisms (SNPs).

<p>Bp = base pairs; chr: chromosome; HGVS: Human Genome Variation Society. The position reflects the distance from the short-arm telomere.</p