Gauge coupling flux thresholds, exotic matter and the unification scale in F-SU(5) GUT

We explore the gauge coupling relations and the unification scale in F-theory SU(5) GUT broken down to the Standard Model by an internal U(1)Y gauge flux. We consider variants with exotic matter representations which may appear in these constructions and investigate their role in the effective field theory model. We make a detailed investigation on the conditions imposed on the extraneous matter to raise the unification scale and make the color triplets heavy in order to avoid fast proton decay. We also discuss in brief the implications on the gaugino masses.Comment: 20 pages, 3 figures, references and extended comments on KK thresholds effects adde

Scherk-Schwarz reduction of M-theory on G2-manifolds with fluxes

We analyse the 4-dimensional effective supergravity theories obtained from the Scherk--Schwarz reduction of M-theory on twisted 7-tori in the presence of 4-form fluxes. We implement the appropriate orbifold projection that preserves a G2-structure on the internal 7-manifold and truncates the effective field theory to an N=1, D=4 supergravity. We provide a detailed account of the effective supergravity with explicit expressions for the Kaehler potential and the superpotential in terms of the fluxes and of the geometrical data of the internal manifold. Subsequently, we explore the landscape of vacua of M-theory compactifications on twisted tori, where we emphasize the role of geometric fluxes and discuss the validity of the bottom-up approach. Finally, by reducing along isometries of the internal 7-manifold, we obtain superpotentials for the corresponding type IIA backgrounds.Comment: 43 pages, Latex; v3 typos corrected, one reference added, JHEP versio

Electroweak Supersymmetry around the Electroweak Scale

Inspired by the phenomenological constraints, LHC supersymmetry and Higgs searches, dark matter search as well as string model building, we propose the electroweak supersymmetry around the electroweak scale: the squarks and/or gluinos are around a few TeV while the sleptons, sneutrinos, bino and winos are within one TeV. The Higgsinos can be either heavy or light. We consider bino as the dominant component of dark matter candidate, and the observed dark matter relic density is achieved via the neutralino-stau coannihilations. Considering the Generalized Minimal Supergravity (GmSUGRA), we show explicitly that the electroweak supersymmetry can be realized, and the gauge coupling unification can be preserved. With two Scenarios, we study the viable parameter spaces that satisfy all the current phenomenological constraints, and we present the concrete benchmark points. Furthermore, we comment on the fine-tuning problem and LHC searches.Comment: RevTex4, 28 pages, 8 figures, 8 tables, version to appear in EPJ

Community advisory boards guiding engaged research efforts within a clinical translational sciences award: Key contextual factors explored

Background: Engaging stakeholders in research carries the promise of enhancing the research relevance, transparency, and speed of getting findings into practice. By describing the context and functional aspects of stakeholder groups, like those working as community advisory boards (CABs), others can learn from these experiences and operationalize their own CABs. Our objective is to describe our experiences with diverse CABs affiliated with our community engagement group within our institution’s Clinical Translational Sciences Award (CTSA). We identify key contextual elements that are important to administering CABs. Methods: A group of investigators, staff, and community members engaged in a 6-month collaboration to describe their experiences of working with six research CABs. We identified the key contextual domains that illustrate how CABS are developed and sustained. Two lead authors, with experience with CABs and identifying contextual domains in other work, led a team of 13 through the process. Additionally, we devised a list of key tips to consider when devising CABs. Results: The final domains include (1) aligned missions among stakeholders (2) resources/support, (3) defined operational processes/shared power, (4) well-described member roles, and (5) understanding and mitigating challenges. The tips are a set of actions that support the domains. Conclusions: Identifying key contextual domains was relatively easy, despite differences in the respective CAB’s condition of focus, overall mission, or patient demographics represented. By contextualizing these five domains, other research and community partners can take an informed approach to move forward with CAB planning and engaged research

Seeing through the String Landscape - a String Hunter's Companion in Particle Physics and Cosmology

In this article we will overview several aspects of the string landscape, namely intersecting D-brane models and their statistics, possible model independent LHC signatures of intersecting brane models, flux compactification, moduli stabilization in type II compactifications, domain wall solutions and brane inflation.Comment: 94 pages, Review paper invited and accepted for publication by JHEP, revised version contains several new references and other minor modification

Survey on schizophrenia treatment in Mexico: perception and antipsychotic prescription patterns

BACKGROUND: Since the introduction of antipsychotics, especially the so called atypicals, the treatment of schizophrenia has shown important improvements. At the present time, it is preferred to label clozapine and other antipsychotics sharing similar profiles as second-generation antipsychotics (SGAs). These medications have been proposed by some experts as a first line treatment for schizophrenia. It is critical to have reliable data about antipsychotic prescription in Mexico and to create management guidelines based on expert meetings and not only on studies carried out by the pharmaceutical industry. Only this approach will help to make the right decisions for the treatment of schizophrenia. METHODS: A translated version of Rabinowitz's survey was used to evaluate antipsychotic prescription preferences and patterns in Mexican psychiatrists. The survey questionnaire was sent by mail to 200 psychiatrists from public institutions and private practice in Mexico City and Guadalajara, Mexico. RESULTS: Recommendations for antipsychotics daily doses at different stages of the treatment of schizophrenia varied widely. Haloperidol was considered as the first choice for the treatment of positive symptoms. On the contrary, risperidone was the first option for negative symptoms. For a patient with a high susceptibility for developing extrapyramidal symptoms (EPS), risperidone was the first choice. It was also considered that SGAs had advantages over typical antipsychotics in the management of negative symptoms, cognitive impairment and fewer EPS. Besides, there was a clear tendency for prescribing typical antipsychotics at higher doses than recommended and inadequate doses for the atypical ones. CONCLUSIONS: Some of the obstacles for the prescription of SGAs include their high cost, deficient knowledge about their indications and dosage, the perception of their being less efficient for the treatment of positive symptoms and the resistance of some Mexican physicians to change their prescription pattern. It is necessary to reach a consensus, in order to establish and standardize the treatment of schizophrenia, based on the information reported in clinical trials and prevailing economic conditions in Mexico

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy

On the formation of globular cluster systems in a hierarchical universe

We have investigated the formation of globular cluster (GC) systems in the fiducial semi-analytic model of galaxy formation of Cole et al., by assuming that GCs are formed at high redshifts (z>5) in protogalactic fragments, and during the subsequent gas-rich merging of these fragments. Under these assumptions we have simulated the GC systems of 450 elliptical galaxies, and find that the majority (93 per cent) are intrinsically bimodal in metallicity. We find that, in the mean, the metal-rich GC subpopulations are younger than the metal-poor GC subpopulations, with ages of 9 and 12 Gyr respectively, and that the mean ages of the metal-rich GCs are dependent upon host galaxy luminosity and environment (halo circular velocity), whereas the metal-poor GCs are not. We find that the continued gaseous merging of the protogalactic fragments leads to significant age-structure amongst the metal-rich GCs. These GCs exhibit a large age-range (5 to 12 Gyr), which increases for low-luminosity galaxies, and for galaxies in low circular velocity haloes. Moreover, the metal-rich GCs associated with low-luminosity field and/or group ellipticals are 2 Gyr younger than the metal-rich GCs in luminous cluster ellipticals. We find that the total GC populations scale with host galaxy luminosity as , a result in agreement with observations of luminous elliptical galaxies. This scaling is due to a systematic increase in the / ratios of the galaxy haloes with luminosity for LV,gal>L galaxies in the model. A comparison between the luminosity growth of the model ellipticals and their GC formation indicates that mergers do not significantly affect SN at z<2. We find the mean colours of the both the metal-rich and metal-poor GCs exhibit only a weak dependence upon host galaxy luminosity, a result consistent with contemporary observations. We conclude that gaseous merging, the bulk of which occurs at 1≤z≤4 in our ΛCDM model, leads to the formation of the metal-rich peak of the GC systems of elliptical galaxies. We suggest that the formation and subsequent truncation of the metal-poor GCs in the protogalactic fragments is closely related to the star formation rate in these fragments, which may have been significantly higher at very early times

Forming Globular Cluster Systems Semi-analytically

We describe a scheme for the formation of globular cluster systems in early-type galaxies using a semi-analytic model of galaxy formation. Operating within a Lambda CDM cosmology, we assume that metal-poor globular clusters are formed at high-redshift in pre-galactic fragments, and that the subsequent gas-rich merging of these fragments leads to the formation of metal-rich clusters. We compare our results with contemporary data, and look at the particular case of the globular cluster and stellar metallicity distribution function of the nearby elliptical galaxy Centaurus A.Comment: 2 figures, rmaa.cls, to appear in 'Galaxy evolution: theory and observations', Eds. V. Avila-Reese, C. Firmani, C. Frenk, & C. Allen, RevMexAA SC (2002