Onset of vitiligo in a patient with acquired secondary hypogonadism under treatment with testosterone gel 2%: inside the pathogenesis

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Immunohistochemical evaluation and clinicopathological correlation of Mer and Axl tyrosine kinase TAM receptors in cutaneous melanoma

Background: Malignant melanoma (MM) is potentially the most dangerous form of skin tumor. In the last few years, the so-called TAM receptors, a unique family of tyrosine kinase (TK) receptors,have become increasingly important. Objectives: To evaluate Mer and Axl TAM receptor expression to find clinicopathological features that could explain the biological behavior of MM. Patients and Methods: Clinicopathological data were obtained from an MM electronic database at our Institute. We reviewed 24 cutaneous MM specimens. TAM receptor expression was assayed using immunohistochemistry. Combinative semiquantitative scoring was used for the evaluation of TAM receptor expression (MerTK and AxlTK). Appropriate statistical methods were used to evaluate a possible correlation between TAM receptor expression and the clinicopathological variables of the MM samples (univariate analysis and multivariate analysis). Results: MerTK and AxlTK were expressed differently in the MM samples, with a major expression of the first receptor. The cells of the tumor microenvironment contributed to the majority of the total score. A significant association was found between AxlScore and the site of the tumor and between AxlScore and the variable ulceration; another correlation was found between MerScore and the lowing characteristics: pathological stage of the tumor (pT), sex, ulceration, and tumor-infiltrating lymphocytes. Conclusions: All correlations between the expression of MerTK and AxlTK with the clinical and histological variables of MM should be validated in a large group of people in order to increase the validity and the impact of our observations, with subsequently therapeutic implications in the era of the “targeted therapy.

Systemic Immunobiological, Immunosuppressant and Oncologic Agents for the Treatment of Dermatologic Diseases during the SARS-Cov-2 (COVID19) Pandemic Emergency: a Quick Review for a Quick Consultation

The Precision Medicine Era has helped to better manage patients with immunological and oncological disease, improving the quality of life of this class of patients. Regarding the management of these patients and positivity to SARS-Cov2, currently, limited data is available and information is evolving. In this quick review we have analyzed the mechanisms of action and related infective risk of drugs used for the treatment of immune-mediated and oncologic skin conditions during the daily clinical practice. In general immunosuppressant and antineoplastic agents for dermatologic treatments do not require suspension and do not require special measures, if not those commonly observed. In the case of a COVID19 patient with complication (such as pneumonia, respiratory failure), treatment suspension should always be considered after taking into account the general condition of the patient, the risk-benefit ratio and the pathophysiology of COVID19 infection. The COVID19 emergency pandemic does not imply an under-treatment of existing skin conditions, which together with the SARS-Cov2 infection may jeopardize the patient's life. This article is protected by copyright. All rights reserved

Dermoscopical and pathological findings in pseudoxanthoma elasticum-like papillary dermal elastolysis

Dermoscopical and pathological findings in pseudoxanthoma elasticum-like papillary dermal elastolysi

Onset of breast basal cell carcinomas during pregnancy: case report and state of the art

Onset of breast basal cell carcinomas during pregnancy: case report and state of the ar

Immunohistochemical evaluation and clinicopathological correlation of Mer and Axl tyrosine kinase Tam receptors in cutaneous melanoma

In the last few years TAM receptors, which are a unique family of receptor tyrosine kinase (RTK), have acquired increasing importance. The aim of our study was to evaluate Mer and Axl TAM receptors expression in malignant melanoma (MM) samples, in order to find clinicopathological features that could explain the different biological behavior of MM. Mer an Axl Tam receptors are a further important pathway that, in the future, could be more studied for the pathogenesis of MM, in order to expand the spectrum of relative target treatments

Hematoma-like primary cutaneous peripheral T-cell lymphoma: a rare clinical presentation

We described a case of hematoma-like primary cutaneous peripheral T-cell lymphoma (H-PCTCL). The relationship between atypical T lymphocytes and hematoma-like appearance, as well as the prognosis of this rare manifestation of the cutaneous lymphoma, remain unknown