Estudio de la capacidad estabilizadora del peroné en fracturas de tibia de conejo

El objetivo de este trabajo es estudiar la capacidad estabilizadora del peroné en fracturas de tibia. Si dicha capacidad es suficiente, sería posible evitar el uso de sistemas de fijación en los experimentos de laboratorio con este tipo de fracturas. Para comprobarlo se ha realizado una simulación computacional por elementos finitos de la tibia y el peroné de un conejo, con una fractura en el tercio medio superior de la diáfisis sin ningún elemento estabilizador. El conjunto ha sido sometido a las cargas más desfavorables del proceso de salto comprobándose que en este caso el peroné fracturaría en su parte inferior del mismo modo que sucede en la experimentación en laboratorio

Some stochastics on monotone functions

AbstractA measure of departures of monotonicity of a given function, the Lr-DIP, 1 ⩽ r ⩽ ∞, is introduced. Our analysis is performed to cover two different situations: When the function is known our interest is related to its behavior in a stochastic model. However, in most cases, the knowledge of the function is obtained through a preliminary estimation of the function. In both situations the aim focuses in the obtainment of strong consistency results

Estudio de la capacidad estabilizadora del peroné en fracturas de tibia de conejo

El objetivo de este trabajo es estudiar la capacidad estabilizadora del peroné en fracturas de tibia. Si dicha capacidad es suficiente, sería posible evitar el uso de sistemas de fijación en los experimentos de laboratorio con este tipo de fracturas. Para comprobarlo se ha realizado una simulación computacional por elementos finitos de la tibia y el peroné de un conejo, con una fractura en el tercio medio superior de la diáfisis sin ningún elemento estabilizador. El conjunto ha sido sometido a las cargas más desfavorables del proceso de salto comprobándose que en este caso el peroné fracturaría en su parte inferior del mismo modo que sucede en la experimentación en laboratorio

Compactifications of the Klebanov-Witten CFT and new AdS3 backgrounds

In this paper we find various new backgrounds in Type IIB, IIA and M-theory with an AdS3-factor. The solutions are smooth and preserve small amounts of SUSY. These new backgrounds are found by application of non-Abelian T-duality (sometimes combined with T-duality) on the supergravity solution dual to the Klebanov-Witten CFT compactified to two dimensions. The field theory aspects encoded by these backgrounds are studied. We give a detailed account of conserved charges, central charges, entanglement entropy and Wilson loops. Further, we present a possible field theory interpretation for our backgrounds. © 2015, The Author(s)

Some stochastics on monotone functions

Centro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai

Adrenomedullin, a novel target for neurodegenerative diseases

Neurodegenerative diseases represent a heterogeneous group of disorders whose common characteristic is the progressive degeneration of neuronal structure and function. Although much knowledge has been accumulated on the pathophysiology of neurodegenerative diseases over the years, more efforts are needed to understand the processes that underlie these diseases and hence to propose new treatments. Adrenomedullin (AM) is a multifunctional peptide involved in vasodilation, hormone secretion, antimicrobial defense, cellular growth, and angiogenesis. In neurons, AM and related peptides are associated with some structural and functional cytoskeletal proteins that interfere with microtubule dynamics. Furthermore, AM may intervene in neuronal dysfunction through other mechanisms such as immune and inflammatory response, apoptosis, or calcium dyshomeostasis. Alterations in AM expression have been described in neurodegenerative processes such as Alzheimer’s disease or vascular dementia. This review addresses the current state of knowledge on AM and its possible implication in neurodegenerative diseases

Reduced adrenomedullin parallels microtubule dismantlement in frontotemporal lobar degeneration

Tau is a microtubule-associated protein highly expressed in neurons with a chief role in microtubule dynamics and axonal maintenance. Adrenomedullin gene (ADM) codifies for various peptides that exert broad range of actions in the body. Previous works in our groups have shown that increased ADM products are positively correlated to microtubule disruption and tau pathology in Alzheimer's disease brains. In the present study, we explore the involvement of ADM in the neuropathology of frontotemporal lobar degeneration that presents with primary tauopathy (FTLD-tau). Proteins from frontal cortices of FTLD-tau patients and age- and sex-matched non-demented controls were analyzed with antibodies against different microtubule components, including adrenomedullin, and synaptic markers. Tau pathology in frontal cortex from FTLD patients was confirmed. Levels of total βIII-tubulin as well as acetylated and detyrosinated tubulins, two markers of stabilized and aged microtubules, were significantly reduced and directly correlated with PSD95 and proBDNF in FTLD-tau patients when compared to non-demented controls. In contrast, no change in actin cytoskeleton was found. Interestingly, changes in microtubule elements, indicators of disturbed axonal preservation, were accompanied by decreased levels of free adrenomedullin, although no association was found. Altogether, reduced levels of adrenomedullin might not be directly linked to the microtubule pathology of FTLD-tau, but based on previous works, it is suggested that downregulation of ADM might be an adaptive attempt of neurons to mitigate microtubule disruption