55 research outputs found
Enhancement of Anisotropy due to Fluctuations in Quasi-One-Dimensional Antiferromagnets
It is shown that the observed anisotropy of magnetization at high magnetic
fields in RbMnBr3 , a quasi-one-dimensional antiferromagnet on a distorted
stacked triangular lattice, is due to quantum and thermal fluctuations. These
fluctuations are taken into account in the framework of linear spin-wave theory
in the region of strong magnetic fields. In this region the divergent
one-dimensional integrals are cut off by magnetic field and the bare easy-plane
anisotropy. Logarithmical dependence on the cutoff leads to the "enhancement"
of the anisotropy in magnetization. Comparison between magnetization data and
our theory with parameters obtained from neutron scattering experiments has
been done.Comment: 15 pages + 5 postscript figures available upon request, RevTex
New Molecular Complex of Ammonium Glycyrrhizate with Rutin
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Received:03.11.2021. Revised: 21.12.2021. Accepted: 21.12.2021. Available online: 11.01.2022.A new 1:1 molecular complex of triterpene glycoside ammonium glycyrrhizate (GC) with flavonoid glycoside rutin (Rut) was obtained in aqueous ethanol. The stability constant (9.70.2)104 (mol/L)β1 was calculated for the complex via isomolar curves. The complexation was studied by UV- and ATR IR-Fourier spectroscopy and a method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex. A preliminary antioxidant activity assessment of the complex was made.This study was carried out with the experimental equipment of the Sevastopol State University (project PR/807-42/2017)
NEW MOLECULAR COMPLEX OF AMMONIUM GLYCYRRHIZATE WITH RUTIN
This study was carried out on the experimental equipment of the Sevastopol State University (project PR/807-42/2017)
Magnetoresistive study of antiferromagnetic--weak ferromagnetic transition in single-crystal LaCuO
The resistive measurements were made to study the magnetic field-induced
antiferromagnetic (AF) - weak ferromagnetic (WF) transition in LaCuO
single-crystal. The magnetic field (DC or pulsed) was applied normally to the
CuO layers. The transition manifested itself in a drastic decrease of the
resistance in critical fields of ~5-7 T. The study is the first to display the
effect of the AF -WF transition on the conductivity of the LaCuO
single-crystal in the parallel - to - CuO layers direction. The results
provide support for the 3-dimensional nature of the hopping conduction of this
layered oxide.Comment: 8 pages, 7 figures, RevTe
Sensitive Search for a Permanent Muon Electric Dipole Moment
We are proposing a new method to carry out a dedicated search for a permanent
electric dipole moment (EDM) of the muon with a sensitivity at a level of
10^{-24} e cm. The experimental design exploits the strong motional electric
field sensed by relativistic particles in a magnetic storage ring. As a key
feature, a novel technique has been invented in which the g-2 precession is
compensated with radial electric field. This technique will benefit greatly
when the intense muon sources advocated by the developers of the muon storage
rings and the muon colliders become available.Comment: 16 pages, 3 figures. Submitted for publication in Proceedings of the
International Workshop on High Intensity Muon Sources (HIMUS99), KEK, Japan,
December 1-4 199
First Observation of Self-Amplified Spontaneous Emission in a Free-Electron Laser at 109 nm Wavelength
We present the first observation of Self-Amplified Spontaneous Emission
(SASE) in a free-electron laser (FEL) in the Vacuum Ultraviolet regime at 109
nm wavelength (11 eV). The observed free-electron laser gain (approx. 3000) and
the radiation characteristics, such as dependency on bunch charge, angular
distribution, spectral width and intensity fluctuations all corroborate the
existing models for SASE FELs.Comment: 6 pages including 6 figures; e-mail: [email protected]
Π‘ΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΡ Π°Π½ΡΠΈΠ³Π΅Π½Π½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈΜ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ ΡΠΏΠΈΡΠΎΠΏΡ Π±Π΅Π»ΠΊΠΎΠ², Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Ρ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΠΎΠΈΜ, ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°ΡΡ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΈΜ ΠΊΡΠΎΠ²ΠΈ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ
Aim. The aim of the study was to evaluate the ability of pMEL-TCI and pMEL-A0201 DNA-constructs encoding artificial polyepitope melanoma antigens to induce antitumor T cell immune response ex vivo. material and methods. Dendritic cells were obtained from peripheral blood mononuclear cells of HLA-A02:01-positive donors; DCs transfected with target DNA vaccine constructions were co-cultured with autologous T lymphocytes to stimulate anti-tumor effector T cells. Specific activity of ex vivo stimulated PBMC was assessed (1) by their ability to cause lysis of human melanoma Mel Is cells, and (2) by the level of their granzyme-producing activity. A recombinant plasmid encoding the full-length MART-1 melanoma antigen was used as a positive control. results. All DNA vaccine constructions as well as positive control construction were found to be able to stimulate specific anti-tumor immune responses of autologous PBMC ex vivo, and these PBMC were found to induce melanoma Mel Is cells lysis. Both the efficiency of induced cytotoxic responses and the level of granzymes production stimulated with DCs transfected with pMel-A0201 significantly exceeded those stimulated with DCs transfected with either pMel-TCI or with DNA construction encoding the full-length MART-1 protein. The cytotoxicity level correlates with the level of granzyme B production in CD8+ T lymphocytes. conclusion. DNA vaccine constructions encoding artificial polypeptides composed of tumor antigen epitopes can stimulate the antitumor cytotoxic response. This approach can be used as the basis for the development of new methods of immunotherapy for cancer.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΡΠ΅Π½ΠΈΡΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΠΠ-ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈΜ pMEL-TCI ΠΈ pMEL-A0201, ΠΊΠΎΠ΄ΠΈΡΡΡΡΠΈΡ
ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΏΠΎΠ»ΠΈΡΠΏΠΈΡΠΎΠΏΠ½ΡΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½Ρ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ, ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΈΜ ΠΎΡΠ²Π΅Ρ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ Π’-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ex vivo. ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΈΜ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ Π’-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ex vivo Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ (ΠΠΠ) ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΈΜ ΠΊΡΠΎΠ²ΠΈ HLA-A*02:01 ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΡ
Π΄ΠΎΠ½ΠΎΡΠΎΠ². Π¦ΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Π΄Π²ΡΠΌΡ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ: 1) ΠΏΠΎ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΠΠ, ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ, ΡΡΠ°Π½ΡΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π°ΠΌΠΈ pMEL-TCI ΠΈ pMEL-A0201, Π²ΡΠ·ΡΠ²Π°ΡΡ Π»ΠΈΠ·ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π»ΠΈΠ½ΠΈΠΈ Mel Is, Π° ΡΠ°ΠΊΠΆΠ΅ 2) ΠΏΠΎ ΡΡΠΎΠ²Π½Ρ ΠΈΡ
Π³ΡΠ°Π½Π·ΠΈΠΌ-ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΡΡΠ΅ΠΈΜ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»Π°ΡΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½Π°Ρ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π°, ΠΊΠΎΠ΄ΠΈΡΡΡΡΠ°Ρ ΠΏΠΎΠ»Π½ΠΎΡΠ°Π·ΠΌΠ΅ΡΠ½ΡΠΈΜ Π°Π½ΡΠΈΠ³Π΅Π½ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ MART-1. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ Π΄Π΅Π½Π΄ΡΠΈΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ HLA-A*02:01+ Π΄ΠΎΠ½ΠΎΡΠΎΠ², ΡΡΠ°Π½ΡΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΡΠΌΠΈ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΡΠΌΠΈ pMel-A0201 ΠΈ pMel-TCI, ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π»ΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΡ
ΠΠΠ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ Mel Is. ΠΠ°ΠΊ ΠΏΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°, ΡΠ°ΠΊ ΠΈ ΠΏΠΎ ΡΡΠΎΠ²Π½Ρ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ Π³ΡΠ°Π½Π·ΠΈΠΌΠ° B Π°Π»Π»Π΅Π»Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΏΡΠ΅Π²Π·ΠΎΡΠ»Π° ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΡ, ΠΊΠΎΠ΄ΠΈΡΡΡΡΡΡ ΠΏΠΎΠ»Π½ΠΎΡΠ°Π·ΠΌΠ΅ΡΠ½ΡΠΈΜ Π±Π΅Π»ΠΎΠΊ MART1. Π·Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΠ-Π²Π°ΠΊΡΠΈΠ½Π½ΡΠ΅ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ, ΠΊΠΎΠ΄ΠΈΡΡΡΡΠΈΠ΅ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΏΠΎΠ»ΠΈΠΏΠ΅ΠΏΡΠΈΠ΄Ρ, ΡΠΎΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ ΠΈΠ· ΡΠΏΠΈΡΠΎΠΏΠΎΠ² ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ², ΡΠΏΠΎΡΠΎΠ±Π½Ρ ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΈΜ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΈΜ ΠΎΡΠ²Π΅Ρ. ΠΠ°Π½Π½ΡΠΈΜ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΌΠΎΠΆΠ΅Ρ ΠΏΠΎΡΠ»ΡΠΆΠΈΡΡ ΠΎΡΠ½ΠΎΠ²ΠΎΠΈΜ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Π½ΠΎΠ²ΡΡ
ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΈΜ
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