The influence of laser relative intensity noise in the Laser Interferometer Space Antenna

LISA is an upcoming ESA mission that will detect gravitational waves in spaceby interferometrically measuring the separation between free-falling testmasses at picometer precision. To reach the desired performance, LISA willemploy the noise reduction technique time-delay interferometry (TDI), in whichmultiple raw interferometric readouts are time shifted and combined into thefinal scientific observables. Evaluating the performance in terms of these TDIvariables requires careful tracking of how different noise sources propagatethrough TDI, as noise correlations might affect the performance in unexpectedways. One example of such potentially correlated noise is the relativeintensity noise (RIN) of the six lasers aboard the three LISA satellites, whichwill couple into the interferometric phase measurements. In this article, wecalculate the expected RIN levels based on the current mission architecture andthe envisaged mitigation strategies. We find that strict requirements on thetechnical design reduce the effect from approximately 8.7 pm/rtHz perinter-spacecraft interferometer to that of a much lower sub-1 pm/rtHz noise,with typical characteristics of an uncorrelated readout noise after TDI. Ourinvestigations underline the importance of sufficient balanced detection of theinterferometric measurements.<br

An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent

Background: The carboxylesterase Notum has been shown to act as a key negative regulator of the Wnt signalling pathway by mediating the depalmitoleoylation of Wnt proteins. LP-922056 (1) is an orally active inhibitor of Notum. We are investigating the role of Notum in modulating Wnt signalling in the central nervous system and wished to establish if 1 would serve as a peripherally restricted control. An accessible and improved synthetic route would allow 1 to become more readily available as a chemical tool to explore the fundamental biology of Notum and build target validation to underpin new drug discovery programs. / Results: An improved, scalable synthesis of 1 is reported. Key modifications include: (1) the introduction of the C7-cyclopropyl group was most effectively achieved with a Suzuki–Miyaura cross-coupling reaction with MIDA-boronate 11 (5 → 6); and (2) C6 chlorination was performed with 1-chloro-1,2-benziodoxol-3-one (12) (6 → 7) as a mild selective electrophilic chlorination agent. This 7-step route has been reliably performed on large scale to produce multigram quantities of 1 in good efficiency and high purity. Pharmacokinetic studies in mouse showed CNS penetration of 1 is very low with brain:plasma concentration ratio of just 0.01. A small library of amides 17 were prepared from acid 1 to explore if 1 could be modified to deliver a CNS penetrant tool by capping off the acid as an amide. Although significant Notum inhibition activity could be achieved, none of these amides demonstrated the required combination of metabolic stability along with cell permeability without evidence of P-gp mediated efflux. / Conclusion: Mouse pharmacokinetic studies demonstrate that 1 is unsuitable for use in models of disease where brain penetration is an essential requirement of the compound but would be an ideal peripherally restricted control. These data will contribute to the understanding of drug levels of 1 to overlay with appropriate in vivo efficacy endpoints, i.e. the PK-PD relationship. The identification of a suitable analogue of 1 (or 17) which combines Notum inhibition with CNS penetration would be a valuable chemical probe for investigating the role of Notum in disease models

On birational involutions of P3P^3

Let $X$ be a rationally connected three-dimensional algebraic variety and let $\tau$ be an element of order two in the group of its birational selfmaps. Suppose that there exists a non-uniruled divisorial component of the $\tau$-fixed point locus. Using the equivariant minimal model program we give a rough classification of such elements.Comment: 24 pages, late

Chemical ordering in magnetic FePd / Pd(001) epitaxial thin films induced by annealing

Chemically disordered FePd epitaxial layers are grown at room temperature by molecular beam epitaxy on a Pd(001) buffer layer and then annealed in order to induce the chemically ordered L10 (AuCu I) structure. Contrary to what is observed in the case of ordering during growth above room temperature, the ordered structure appears here with the three possible variants of the L10 phase. The ratio of the three different variant volumes is set by the residual epitaxial strain in the layer before annealing. It thus explains that for long annealing times, the long-range order parameter associated with the L10 variant with c along the (100) growth direction saturates at a value close to 0.65, and never reaches unity. Magnetic consequences of the ordering are studied

Crossover from spin accumulation into interface states to spin injection in the germanium conduction band

Electrical spin injection into semiconductors paves the way for exploring new phenomena in the area of spin physics and new generations of spintronic devices. However the exact role of interface states in spin injection mechanism from a magnetic tunnel junction into a semiconductor is still under debate. In this letter, we demonstrate a clear transition from spin accumulation into interface states to spin injection in the conduction band of $n$-Ge. We observe spin signal amplification at low temperature due to spin accumulation into interface states followed by a clear transition towards spin injection in the conduction band from 200 K up to room temperature. In this regime, the spin signal is reduced down to a value compatible with spin diffusion model. More interestingly, we demonstrate in this regime a significant modulation of the spin signal by spin pumping generated by ferromagnetic resonance and also by applying a back-gate voltage which are clear manifestations of spin current and accumulation in the germanium conduction band.Comment: 5 pages, 4 figure

Spinoza

"Spinoza", second edition. Encyclopedia entry for the Springer Encyclopedia of EM Phil and the Sciences, ed. D. Jalobeanu and C. T. Wolfe

Interacting Preformed Cooper Pairs in Resonant Fermi Gases

We consider the normal phase of a strongly interacting Fermi gas, which can have either an equal or an unequal number of atoms in its two accessible spin states. Due to the unitarity-limited attractive interaction between particles with different spin, noncondensed Cooper pairs are formed. The starting point in treating preformed pairs is the Nozi\`{e}res-Schmitt-Rink (NSR) theory, which approximates the pairs as being noninteracting. Here, we consider the effects of the interactions between the Cooper pairs in a Wilsonian renormalization-group scheme. Starting from the exact bosonic action for the pairs, we calculate the Cooper-pair self-energy by combining the NSR formalism with the Wilsonian approach. We compare our findings with the recent experiments by Harikoshi {\it et al.} [Science {\bf 327}, 442 (2010)] and Nascimb\`{e}ne {\it et al.} [Nature {\bf 463}, 1057 (2010)], and find very good agreement. We also make predictions for the population-imbalanced case, that can be tested in experiments.Comment: 10 pages, 6 figures, accepted version for PRA, discussion of the imbalanced Fermi gas added, new figure and references adde

Repeatability of beach morphology change under identical wave forcing

Laboratory investigations of beach morphology change under wave action are undertaken to gain insight into coastal processes, design coastal structures and validate the predictions of numerical models. For the results of such experiments to be reliable, it is necessary that they are repeatable. The equilibrium beach concept, that beach morphology will evolve to a quasi-static equilibrium shape for a given forcing suggests that experiments should be repeatable to some degree. However, sediment transport in turbulent breaking and broken waves is complex and highly variable and the level of repeatability at different temporal and spatial scales is challenging to measure, as such, previous work has restricted comparisons to small numbers of waves. Here we use the results of two identical, 20-h large-scale wave flume experiments to investigate the repeatability of sediment transport and beach morphology change under waves at timescales down to individual swash events. It is shown that while flow characteristics from identical swash events are very repeatable, the sediment transported can be very different in both magnitude and direction due to differences in turbulence, sediment advection and morphological feedback. Over longer periods containing multiple matching swash events however, the beach responds in a very similar manner, with the level of morphological repeatability increasing with time. The results also demonstrate that gross swash zone sediment transport remains high even as a beach profile approaches quasi-equilibrium, but the proportion of individual swash events that cause large sediment fluxes (>±7.5 kg/event/m) reduces with time. The results of this laboratory study indicate that beach morphology change has a level of determinism over timescales of several minutes and longer, giving confidence in the results from physical modelling studies. However, the large differences in sediment transport from apparently identical swash events questions the value in pursuing numerical predictions of sediment transport at the wave-by-wave timescale unless the reversals in sediment transport between apparently near identical swash events can also be predicted

The fables of pity: Rousseau, Mandeville and the animal-fable

Copyright @ 2012 Edinburgh University PressPrompted by Derrida’s work on the animal-fable in eighteenth-century debates about political power, this article examines the role played by the fiction of the animal in thinking of pity as either a natural virtue (in Rousseau’s Second Discourse) or as a natural passion (in Mandeville’s The Fable of the Bees). The war of fables between Rousseau and Mandeville – and their hostile reception by Samuel Johnson and Adam Smith – reinforce that the animal-fable illustrates not so much the proper of man as the possibilities and limitations of a moral philosophy that is unable to address the political realities of the state