Strengths and weaknesses of inviting men to a voluntary-based domestic violence intervention

This study examines the factors motivating domestic violence perpetrators to participate in a voluntary-based intervention program. The experiences and determining factors around men’s positive and negative responses to this invitation were examined through semi-structured interviews with professionals, observations, and reflexive notes during the first meeting with 29 men. Two major themes emerged from the thematic analysis: the factors making men more likely to attend the first meeting or resisting the group intervention. These findings can help professionals recognize the challenges of inviting perpetrators to interventions, especially in countries with insufficient laws for mandated domestic violence perpetrator programs. The paper discusses the importance during the first meeting of building rapport and trust and recognizing complex family histories to encourage voluntary attendance and intervention engagement

TRAKYA HAVZASI (BOZCAADA - KIYIKÖY) TERSİYER KARBONATLARININ (SOĞUCAK FORMASYONU) SEDİMANTOLOJİK – STRATİGRAFİK DEĞERLENDİRİLMESİ

Trakya havzasında yüzeyleyen Soğucak formasyonu genelde resifal kireçtaşı özelliğinde olup, havzadaki petrol arama çalışmalarında hedef seviyelerden birisini teşkil eder. Bu birim bazı alanlarda doğrudan temel kayaları üzerine uyumsuz olarak gelmektedir. Bazı bölgelerde ise silisiklastik ağırlıklı (Koyunbaba formasyonu) birimlerle geçişlidir. Soğucak formasyonu, Erken-Orta Eosen’de başlayan ve Erken Oligosen başlarına kadar sü- ren bir transgresyon sonucunda şelf ortamında depolanan resif-kıyı karmaşığı karbonatlarından oluşmuştur. Formasyonun en alt yaş aralığı olan Erken Eosen yalnızca Bozcaada da yüzeylenmekte olup, Fıçıtepe formasyonu ile geçişlidir. Genelde birim havzanın GD’sunda Orta – Geç Eosen, KD’ sunda ise Geç Eosen-Erken Oligosen zaman aralığında çökelmiştir. Sedimantolojik özellikler ve yaş verileri, Soğucak formasyonunun eski topografya kontrolünde, kıyı morfolojisi özellikleri ve deniz seviyesi değişimleri ile birlikte zaman aşmalı bir transgresyon ürünü olduğunu göstermektedir

Bioactivities of Ethanolic Extract and its Fractions of Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) Species.

Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) have been used for treatment of some illnesses in Turkish folk medicine. In the present study, the ethanolic extract and its fractions obtained using re-extraction by hexane (Hx), chloroform (CHCl3), butanol, and remaining-water (r-H2O) of C. laurifolius were screened for their in vitro bioactivities

Bioactivities of Ethanolic Extract and its Fractions of Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) Species

Background: Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) have been used for treatment of some illnesses in Turkish folk medicine. In the present study, the ethanolic extract and its fractions obtained using re-extraction by hexane (Hx), chloroform (CHCl3), butanol, and remaining-water (r-H2O) of C. laurifolius were screened for their in vitro bioactivities. Materials and Methods: Activities were determined against both standard and the isolated strains of Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, as well as yeasts such as Candida albicans and Candida parapsilosis by microdilution method. Also, antiviral activity of C. laurifolius and S. wiedemannii extracts were tested on herpes simplex virus-1 (HSV-1) and parainfluenza-3 (PI-3) using Madin-Darby bovine kidney and vero cell lines. Results: Tested extracts of C. laurifolius (minimum inhibitory concentration 32 mu g/mL) exerted a strong antimicrobial activity against Gram-negative bacteria of E. coli, P. mirabilis, K. pneumoniae, and A. baumannii. Conclusion: The Hx extract of C. laurifolius (cytopathogenic effect of 32-8 mu g/mL) had antiviral activity on PI-3. Also, the r-H2O, CHCl3, and ethanol extracts (16-<0.25 mu g/mL) of S. wiedemannii had significant antiviral activity on HSV-1, same as control

BOZCAADA' DA (ÇANAKKALE) SOĞUCAK FORMASYONU' NDA SAPTANAN YENİ PALEONTOLOJİK VE SEDİMANTOLOJIK BULGULAR

Trakya ve yakın çevresinde havza kenarı karbonatları olarak geniş alanlarda yüzlekler veren Orta Eosen yaşlı kireçtaşları Soğucak Formasyonu olarak adlandırılmış ve haritalanmıştır (Holmes, 1961; Sümengen ve diğerleri, 1987). Ayrıca, Siyako ve Huvaz (2007) tarafından diğer Eosen birimleri ile birlikte bu formasyonun Trakya havzasındaki konumu ve stratigrafik pozisyonu detaylı bir şekilde tanıtılmıştır. Önceki çalışmalarda Bozcaada' da yüzeylenen Soğucak Formasyonu, Trakya havzası genelinde olduğu gibi Orta Eosen olarak yaşlandırılmıştır (Temel ve Çiftçi, 2002; Kesgin ve Varol, 2003; Siyako ve Huvaz, 2007). Buna karşın formasyona verilen bu zaman aralığının tüm havza ölçeğinde süreklilik göstermediği yer yer Alt Eosen-Oligosen aralığında değiştiğine dair veriler de mevcuttur. Önal (2002) 'de Gelibolu yarımadasında Soğucak Formasyonu'na eş değer olarak ayırdığı ve tanımladığı Başoğlu üyesini Erken Eosen olarak yaşlandırmıştır. Baykal ve diğerleri (2007) ise, Kuzeybatı Trakya havzası genelinde bu formasyon içerisinde yaygın bir Oligosen çökelim sürecini ortaya koymuştur. Bu veriler, Soğucak Formasyonunun Trakya havzasında daha geniş bir yaş aralığında çökelmiş olabileceğini işaretlemektedir

Hypoglycaemic Effect of Seed and Fruit Extracts of Laurel Cherry in Different Experimental Models and Chemical Characterization of the Seed Extract

Laurel cherry (Prunus laurocerasus L.), an evergreen tree from Rosaceae family, is used as a folk medicine for various medical purposes and against diabetes as well in Northern Anatolia. The present study was performed to evaluate in-vivo hypoglycaemic and antidiabetic activities of P. laurocerasus. Hypoglycaemic effect of ethanol extracts of the fruit and seeds were tested on normoglycaemic, glucose loaded and streptozotocin induced diabetic rats. The extracts were given orally to rats and blood glucose levels were determined according to the glucose oxidase method. The results indicated that seed extract showed 20\% inhibition on blood glucose levels on experimental diabetic animals Chemical composition of the bioactive seed extract was analyzed by GC-MS. Oleic, linoleic and palmitic acids were detected as the major components of this extract. Therefore, hypoglycaemic activity of the seeds may be arisen from unsaturated fatty acids

ENOX2 NADH Oxidase: A BCR-ABL1-Dependent Cell Surface and Secreted Redox Protein in Chronic Myeloid Leukemia

Objective: Chronic myeloid leukemia (CML) is a disease caused by the acquisition of BCR-ABL1 fusion in hematopoietic stem cells. In this study, we focus on the oncofetal ENOX2 protein as a potential secretable biomarker in CML. Materials and Methods: We used cell culture, western blot, quantitative RT-PCR, ELISA, transcriptome analyses, and bioinformatics techniques to investigate ENOX2 mRNA and protein expression. Results: Western blot analyses of UT-7 and TET-inducible Ba/F3 cell lines demonstrated the upregulation of the ENOX2 protein. BCR-ABL1 was found to induce ENOX2 overexpression in a kinase-dependent manner. We confirmed increased ENOX2 mRNA expression in a cohort of CML patients at diagnosis. In a series of CML patients, ELISA assays showed a highly significant increase of ENOX2 protein levels in the plasma of patients with CML compared to controls. Reanalyzing the transcriptomic dataset confirmed ENOX2 mRNA overexpression in the chronic phase of the disease. Bioinformatic analyses identified several genes whose mRNA expressions were positively correlated with ENOX2 in the context of BCR-ABL1. Some of them encode proteins involved in cellular functions compatible with the growth deregulation observed in CML. Conclusion: Our results highlight the upregulation of a secreted redox protein in a BCR-ABL1-dependent manner in CML. The data presented here suggest that ENOX2, through its transcriptional mechanism, plays a significant role in BCR-ABL1 leukemogenesis