Mathematical modeling of ultra wideband in vivo radio channel

This paper proposes a novel mathematical model for an in vivo radio channel at ultra-wideband frequencies (3.1–10.6 GHz), which can be used as a reference model for in vivo channel response without performing intensive experiments or simulations. The statistics of error prediction between experimental and proposed model is RMSE = 5.29, which show the high accuracy of the proposed model. Also, the proposed model was applied to the blind data, and the statistics of error prediction is RMSE = 7.76, which also shows a reasonable accuracy of the model. This model will save the time and cost on simulations and experiments, and will help in designing an accurate link budget calculation for a future enhanced system for ultra-wideband body-centric wireless systems

A study of the efficacy of furosemide as a prophylaxis of acute renal failure in coronary artery bypass grafting patients: A clinical trial

BACKGROUND: Renal failure is a frequent event after coronary artery bypass grafting (CABG). Hemodynamic alterations during surgery as well as the underlying disease are the predisposing factors. We aimed to study intermittent furosemide therapy in the prevention of renal failure in patients undergoing CABG. METHODS: In a single-blind randomized controlled trial, 123 elective CABG patients, 18-75 years, entered the study. Clearance of creatinine, urea and water were measured. Patients were randomly assigned into three groups: furosemide in prime (0.3-0.4 mg/kg); intermittent furosemide during CABG (0.2 mg/kg, if there was a decrease in urinary excretion) and control (no furosemide). RESULTS: There was a significant change in serum urea, sodium and fluid balance in �intermittent furosemide� group; other variables did not change significantly before or after the operation. Post-operative fluid balance was significantly higher in �intermittent furosemide� group (2573 ± 205 ml) compared to control (1574 ± 155 ml) (P < 0.010); also, fluid balance was higher in �intermittent furosemide� group (2573 ± 205 ml) compared to �furosemide in prime� group (1935 ± 169 ml) (P < 0.010). CONCLUSION: The study demonstrated no benefit from intermittent furosemide in elective CABG compared to furosemide in prime volume or even placebo. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved

Circulating Tumor DNA in Pediatric Cancer

The measurement of circulating tumor DNA (ctDNA) has gained increasing prominence as a minimally invasive tool for the detection of cancer-specific markers in plasma. In adult cancers, ctDNA detection has shown value for disease-monitoring applications including tumor mutation profiling, risk stratification, relapse prediction, and treatment response evaluation. To date, there are ctDNA tests used as companion diagnostics for adult cancers and it is not understood why the same cannot be said about childhood cancer, despite the marked differences between adult and pediatric oncology. In this review, we discuss the current understanding of ctDNA as a disease monitoring biomarker in the context of pediatric malignancies, including the challenges associated with ctDNA detection in liquid biopsies. The data and conclusions from pediatric cancer studies of ctDNA are summarized, highlighting treatment response, disease monitoring and the detection of subclonal disease as applications of ctDNA. While the data from retrospective studies highlight the potential of ctDNA, large clinical trials are required for ctDNA analysis for routine clinical use in pediatric cancers. We outline the requirements for the standardization of ctDNA detection in pediatric cancers, including sample handling and reproducibility of results. With better understanding of the advantages and limitations of ctDNA and improved detection methods, ctDNA analysis may become the standard of care for patient monitoring in childhood cancers

Challenges toward Sustainability? Experiences and Approaches to Literary Tourism from Iran

Interdisciplinary narrative studies are of great importance in several disciplines, especially in the humanities and social sciences. Cultural tourism and its sub-disciplines, including the complex issue of ‘literary tourism’, is an interdisciplinary field of investigation, positioned in between geography and urban–rural studies. In Iran, this form of tourism has been neglected so far—with no distinction between urban and rural areas—despite a particularly rich literary heritage. The present study recognizes the challenge of literary tourism in Iran, delineating some possible actions to develop it as a future engine of economic growth, especially in rural districts. As a contribution to a refined comprehension of literary tourism development paths, a content analysis was run collecting views and textual data on literary tourism in Iran. The empirical results of this study indicate that the mentioned challenges can be classified into several main dimensions and a broader set of sub-themes. The possible actions responding to such challenges can be classified into more dimensions and a vast number of sub-themes. Actions reducing territorial disparities and fueling entrepreneurship in local communities are appropriate to stimulate the emergence (and, possibly, consolidation) of literary tourism districts in Iran, giving an original contribution to sustainable development especially—but not exclusively—in rural settlements

Motivation-based Market Segmentation in Rural Tourism: the Case of Sámán, Iran

Market segmentation is a pivotal and under-investigated issue when evaluating decision-making processes and motivational factors shaping rural tourism. The present study has examined market segmentsof rural tourists in Iran based on their sociodemographic attributes, travel characteristics and preferred leisure activities, profiling rural tourists on the base of their motivational background. The survey results indicated that rural tourism in the study area is a heterogeneous market, whose development depends on general trends in Middle East tourism market. A comprehensive knowledge of rural tourism actors may help formulating appropriate marketing strategies for internal areas destined to tourism growth

Discrete Model of Ideological Struggle Accounting for Migration

A discrete in time model of ideological competition is formulated taking into account population migration. The model is based on interactions between global populations of non-believers and followers of different ideologies. The complex dynamics of the attracting manifolds is investigated. Conversion from one ideology to another by means of (i) mass media influence and (ii) interpersonal relations is considered. Moreover a different birth rate is assumed for different ideologies, the rate being assumed to be positive for the reference population, made of initially non-believers. Ideological competition can happen in one or several regions in space. In the latter case, migration of non-believers and adepts is allowed; this leads to an enrichment of the ideological dynamics. Finally, the current ideological situation in the Arab countries and China is commented upon from the point of view of the presently developed mathematical model. The massive forced conversion by Ottoman Turks in the Balkans is briefly discussed.Comment: 24 pages, with 5 figures and 52 refs.; prepared for a Special issue of Advances in Complex System

Productivity of various barley (Hordeum vulgare L.) cultivars under semi-arid conditions in southern Russia

ArticleDrought is a significant factor limiting crop production in arid conditions. In the dry climatic weather situation of southern Russia, ten - year laboratory trials and subsequent field experiments were laid out on various barley varieties collected across the globe during 2007 – 2017 period. This study was conducted to ascertain from the collection of barley cultivars of the entire world which one is best suited to stressful climatic conditions by being tolerant to drought, heat and salinity which can be adopted for barley breeding. According to the results obtained, the varieties that are tolerant to dry climatic conditions are as follows: Alga (Lithuania), Brenda, Henni (Germany), Décor (Great Britain), Furat 5 (Syria), Vakula (Ukraine), Ataman (Belarus) and Vladimir (Russia); heat resistant varieties are: Brenda (Germany), Alga (Lithuania), Furat 5 (Syria), Ataman (Belarus) , Vladimir and Ratnik (Russia); Salt - resistant varieties: Alga (Lithuania), Henni (Germany) and Vladimir (Russia). The selected varieties did not show any sign of adverse weather effect resulting in stable grain productivity throughout the entire duration of this research over the years, they had large grain size and stable 1 , 000 grains weight. However, the yield of selected cultivars varied over the years which was about 1.1 – 1.4 t ha - 1

Productivity, quality and economics of four spring wheat (Triticum aestivum L.) cultivars as affected by three cultivation technologies

ArticleManaging farming inputs in wheat production technologies is an issue of paramount importance to attain optimum profitable production. To examine how varying the farming inputs affects the nutrients uptake and productivity of spring wheat (Triticum aestivum L.) cultivars and to determine the economic efficiency of various cultivation technologies, three-year field experiments were laid out at the Russian Research Institute of Agriculture, during the 2015–2017 growing seasons. Experiments were conducted once a year using randomized complete block arranged in a split plot experimental design with three replications, with the cultivation technology treatments (basic, intensive and high intensive technology) as the main plots, and spring wheat cultivars (Zelata, Lubova, Liza and Ester) as the sub-main plots. The highest grain yield (10.8 t ha-1), harvest index (42.9%), gluten content (39.45%) and gluten index (71.17%) observed for spring wheat cultivar Lubova with the moderate application of farming inputs as an intensive cultivation technology. Highest protein content (18.02%) was attained for both intensive and high intensive cultivation technology with the cultivar Lubova, and the highest 1,000 grains weight (46.32 g) was recorded by cultivar Lubova in basic cultivation technology. Applying moderate amount of inputs as an intensive cultivation technology resulted in highest wheat yield and net income

Redesigning Commercial Floating-Gate Memory for Analog Computing Applications

We have modified a commercial NOR flash memory array to enable high-precision tuning of individual floating-gate cells for analog computing applications. The modified array area per cell in a 180 nm process is about 1.5 um^2. While this area is approximately twice the original cell size, it is still at least an order of magnitude smaller than in the state-of-the-art analog circuit implementations. The new memory cell arrays have been successfully tested, in particular confirming that each cell may be automatically tuned, with ~1% precision, to any desired subthreshold readout current value within an almost three-orders-of-magnitude dynamic range, even using an unoptimized tuning algorithm. Preliminary results for a four-quadrant vector-by-matrix multiplier, implemented with the modified memory array gate-coupled with additional peripheral floating-gate transistors, show highly linear transfer characteristics over a broad range of input currents.Comment: 4 pages, 6 figure

Evaluation of ultra-wideband in vivo radio channel and its effects on system performance

This paper presents bit‐error‐rate (BER) performance analysis and improvement using equalizers for an in vivo radio channel at ultra‐wideband frequencies (3.1 GHz to 10.6 GHz). By conducting simulations using a bandwidth of 50 MHz, we observed that the in vivo radio channel is affected by small‐scale fading. This fading results in intersymbol interference affecting upcoming symbol transmission, causing delayed versions of the symbols to arrive at the receiver side and causes increase in BER. A 29‐taps channel was observed from the experimentally measured data using a human cadaver, and BER was calculated for the measured in vivo channel response along with the ideal additive white Gaussian noise and Rayleigh channel models. Linear and nonlinear adaptive equalizers, ie, decision feedback equalizer (DFE) and least mean square (LMS), were used to improve the BER performance of the in vivo radio channel. It is noticed that both the equalizers improve the BER but DFE has better BER compared to LMS and shows the 2‐dB and 4‐dB performance gains of DFE over the LMS at Eb/No = 12 dB and at Eb/No = 14 dB, respectively. The current findings will help guide future researchers and designers in enhancing systems performance of an ultra‐wideband in vivo wireless systems