This paper presents bit‐error‐rate (BER) performance analysis and improvement using equalizers for an in vivo radio channel at ultra‐wideband frequencies (3.1 GHz to 10.6 GHz). By conducting simulations using a bandwidth of 50 MHz, we observed that the in vivo radio channel is affected by small‐scale fading. This fading results in intersymbol interference affecting upcoming symbol transmission, causing delayed versions of the symbols to arrive at the receiver side and causes increase in BER. A 29‐taps channel was observed from the experimentally measured data using a human cadaver, and BER was calculated for the measured in vivo channel response along with the ideal additive white Gaussian noise and Rayleigh channel models. Linear and nonlinear adaptive equalizers, ie, decision feedback equalizer (DFE) and least mean square (LMS), were used to improve the BER performance of the in vivo radio channel. It is noticed that both the equalizers improve the BER but DFE has better BER compared to LMS and shows the 2‐dB and 4‐dB performance gains of DFE over the LMS at Eb/No = 12 dB and at Eb/No = 14 dB, respectively. The current findings will help guide future researchers and designers in enhancing systems performance of an ultra‐wideband in vivo wireless systems
