GEVA “Gestión de evaluaciones”: Desarrollo e implementación de aplicativos multiplataforma que permitan apoyar la gestión de evaluaciones del proceso formativo de los aprendices SENA compatible con personas con discapacidad visual y la plataforma Sofia Plus.

Based on the instructors and apprentices needs, including those who have visual impairment at Sena, and having a tool that allows to know in real time the assessment judgments obtained by the apprentices, that facilitates the control and decision making for a continuous improvement of their formative processIt aims to meet their needs in a simple and accessible way, because in the SofiaPlus platform, more procedures are required to be performed to achieve the same objective, which can be substantially improved with the implementation of the GEVA applications, which can be used in systems such as IOS and Android.Basados en la necesidad de los instructores y aprendices, incluidos los que tienen discapacidad visual del SENA, de contar con una herramienta que permita conocer en tiempo real los juicios valorativos obtenidos por los aprendices, que facilite el control y la toma de decisiones para un mejoramiento continuo de su formación. Pretende de una manera sencilla y accesible, satisfacer sus necesidades, debido a que en la plataforma SofiaPlus, se requieren realizar más procedimientos para la consecución del mismo objetivo, el cual se podrá mejorar sustancialmente con la implementación de los aplicativos GEVA, que pueden ser usados en sistemas como IOS y Android

Instalación y configuración de Zentyal Server en la gestión de infraestructura IT

Utilizando el software de virtualización virtualbox con el fin de contar con un entorno controlado, se hará la instalación y configuración de la plataforma zentyal server, en donde aprovecharemos su gran oferta de servicios como: DHCP server, DNS server, proxy no transparente, cortafuegos, file server, print server y VPN. Para comprobar la correcta instalación y configuración de los servicios anteriormente mencionados, se creará una red local, en donde desde una estación cliente desktop con el sistema operativo ubuntu que estará bajo el dominio del servidor zentyal, se hará la demostración de la versatilidad y facilidad para la gestión de infraestructura TI.Using virtualbox virtualization software in order to have a controlled environment, the installation and configuration of the zentyal server platform will be done, where we will take advantage of its wide range of services such as: DHCP server, DNS server, non-transparent proxy, firewall, file server, print server and VPN. To verify the correct installation and configuration of the aforementioned services, a local network will be created, where from a desktop client station with the ubuntu operating system that will be under the domain of the zentyal server, the versatility and ease for it infrastructure management will be demonstrated

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Atypical Proliferating Trichilemmal Cyst with Malignant Breast Skin Transformation: A Case Report and Review of the Literature

Proliferating trichilemmal tumors (PTTs) are benign adnexal skin neoplasms that arise from the outer root sheath of the hair follicle. These tumors are most commonly observed on the scalp and occur, most of the time, in elderly women. Malignant transformation of these neoplasms is a rare event; less than 50 cases have been reported in the English medical literature. We present the case of a 39-year-old Hispanic woman with a tumor located on the skin of one of her breasts that in her third surgical procedure the histologic examination revealed the presence of a malignant proliferating trichilemmal tumor (MPTT). Furthermore, a review of the medical literature and a discussion of the clinical and pathologic features of this rare entity are provided

Mechanisms of Resistance to First-Line Osimertinib in Hispanic Patients With EGFR Mutant Non-Small Cell Lung Cancer (FRESTON-CLICaP)

Osimertinib is a third generation EGFR-TKI inhibitor approved in the first-line setting for patients with advanced non-small cell lung cancer (NSCLC). Additionally, it represents the treatment of choice in patients who present with T790M mutations and evidence of relapse of the disease. Effectiveness and safety of this drug have been studied in multiple clinical trials and observational studies, however, information regarding outcomes among Hispanic patients treated with Osimertinib is scarce. The objective of this study was to examine real-world effectiveness and safety of first-line Osimertinib in a cohort of Hispanic patients with NSCLC, emphasizing post-progression outcomes

STK11 and KEAP1 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value among Hispanics (STRIKE registry-CLICaP)

Mutations in STK11 (STK11Mut) and, frequently co-occurring, KEAP1 mutations (KEAP1Mut) are associated with poor survival in metastatic Non-small Cell Lung Cancer (mNSCLC) patients treated with immunotherapy. However, there are limited data regarding the prognostic or predictive significance of these genomic alterations among Hispanics

Libro de Actas del XV Congreso de estudiantes de Ciencia, Tecnología e Ingeniería Agronómica

Trabajos científicos, de prácticas, revisiones bibliográficas de estudiantes de la ETSIAAB presentados como comunicaciones orales y pósters

I.amAble: science as a vehicle towards full inclusion

En este proyecto de innovación se persigue enriquecer la formación de los estudiantes de las facultades de ciencias (F. CC.FF. y F. CC.QQ.) mediante una propuesta teórico-práctica basada en la metodología Aprendizaje-Servicio (ApS) y encaminada a facilitar la inclusión de personas con diversidad funcional, especialmente diversidad cognitiva. El proyecto parte del diseño de talleres científicos por los estudiantes universitarios para ser realizados por parejas de estudiantes preuniversitarios de manera colaborativa e inclusiva, ya que un miembro de la pareja procederá de un centro de educación especial y el otro de un centro educativo ordinario (colegio o Instituto de educación secundaria) de la Comunidad de Madrid. Tanto el diseño de los experimentos como su eventual puesta en práctica serán supervisados por los integrantes del proyecto: estudiantes de doctorado, personal de administración y servicios (PAS) y personal docente e investigador (PDI), así como por los colaboradores externos, tanto de centros de educación especial como de centros de enseñanza ordinarios. También se contará con la asesoría pedagógica de PDI de la Facultad de Educación. Las fichas didácticas elaboradas por los estudiantes se harán públicas en la página web del proyecto, vinculada a la Universidad Complutense bajo el nombre I.amAble. Esta plataforma, ya existente, será perfeccionada por estudiantes y PDI de la Facultad de Informática y del Instituto de Tecnología del Conocimiento. De esta manera estarán disponibles con un diseño lo más intuitivo y accesible posible para quienes estén interesados en la divulgación científica desde una perspectiva inclusiva. El equipo informático también desarrollará herramientas que faciliten la elaboración de las fichas como, por ejemplo, la transcripción de textos a pictogramas. El proyecto puede mejorar la calidad de la formación de nuestros estudiantes, desde los aspectos más académicos hasta los más humanistas, como son la profundización en algunos conceptos y su aplicación práctica, el desarrollo de estrategias de comunicación e improvisación, la capacidad de empatía o su contribución al desarrollo del tejido social. Todo ello facilitará su inserción laboral, especialmente en el ámbito de la educación, tanto formal como informal (museos, animación sociocultural, etc.). Este proyecto también contribuirá a la mejora de la cultura científica y a la percepción de nuestra universidad como un espacio abierto a la sociedad y que está a su servicio. Además, facilitará la inclusión de las personas con diversidad funcional mediante el acercamiento compartido a la ciencia.This innovation project seeks to enrich the training of students of science faculties through a theoretical-practical proposal based on the Learning-Service methodology and aimed at facilitating the inclusion of people with functional diversity, especially cognitive diversity. The project is based on the design of scientific workshops by university students to be carried out by pairs of pre-university students in a collaborative and inclusive manner, since one member of the couple will come from a special education center and the other from an ordinary educational center of the Community of Madrid. Both the design of the experiments and their eventual implementation will be supervised by the project members: doctoral students, administration and service staff and teaching and research staff, as well as external collaborators from special education centers as well as ordinary education centers. There will also be pedagogical advisory from the Faculty of Education. The didactic sheets elaborated by the students will be made public on the web page of the project, linked to the Complutense University under the name I.amAble. This platform, already existing, will be improved by students and staff from the IT Faculty and the Institute of Technology of Knowledge. In this way they will be available with a design as intuitive and accessible as possible for those interested in scientific dissemination from an inclusive perspective. The IT team will also develop tools that facilitate the preparation of the files, for example, the transcription of texts to pictograms. The project can improve the quality of the training of our students, from the most academic aspects to the most humanistic ones, such as the deepening of some concepts and their practical application, the development of communication and improvisation strategies, the capacity for empathy or contribution to the development of the social fabric. All this will facilitate their labor insertion, especially in the field of education, both formal and informal (museums, sociocultural animation, etc.). This project will also contribute to the improvement of scientific culture and to the perception of our university as a space open to society and at its service. In addition, it will facilitate the inclusion of people with functional diversity through a shared approach to science.Fac. de Ciencias QuímicasFALSEUniversidad Complutense de MadridReal Sociedad Española de Química - Sección Territorial de MadridCiencias Sin BarrerasConsejería de Educación e Investigación de la Comunidad de Madridsubmitte