Spectral Measurement of Watershed Coefficients in the Southern Great Plains

The author has identified the following significant results. It was apparent that the spectra calibration of runoff curve numbers cannot be achieved on watersheds where significant areas of timber were within the drainage area. The absorption of light by wet soil conditions restricts differentiation of watersheds with regard to watershed runoff curve numbers. It appeared that the predominant factor influencing the classification of watershed runoff curve numbers was the difference in soil color and its associated reflectance when dry. In regions where vegetation grown throughout the year, where wet surface conditions prevail or where watersheds are timbered, there is little hope of classifying runoff potential with visible light alone

Crystallography on Curved Surfaces

We study static and dynamical properties that distinguish two dimensional crystals constrained to lie on a curved substrate from their flat space counterparts. A generic mechanism of dislocation unbinding in the presence of varying Gaussian curvature is presented in the context of a model surface amenable to full analytical treatment. We find that glide diffusion of isolated dislocations is suppressed by a binding potential of purely geometrical origin. Finally, the energetics and biased diffusion dynamics of point defects such as vacancies and interstitials is explained in terms of their geometric potential.Comment: 12 Pages, 8 Figure

On the Efficient Calculation of a Linear Combination of Chi-Square Random Variables with an Application in Counting String Vacua

Linear combinations of chi square random variables occur in a wide range of fields. Unfortunately, a closed, analytic expression for the pdf is not yet known. As a first result of this work, an explicit analytic expression for the density of the sum of two gamma random variables is derived. Then a computationally efficient algorithm to numerically calculate the linear combination of chi square random variables is developed. An explicit expression for the error bound is obtained. The proposed technique is shown to be computationally efficient, i.e. only polynomial in growth in the number of terms compared to the exponential growth of most other methods. It provides a vast improvement in accuracy and shows only logarithmic growth in the required precision. In addition, it is applicable to a much greater number of terms and currently the only way of computing the distribution for hundreds of terms. As an application, the exponential dependence of the eigenvalue fluctuation probability of a random matrix model for 4d supergravity with N scalar fields is found to be of the asymptotic form exp(-0.35N).Comment: 21 pages, 19 figures. 3rd versio

Microrheology, stress fluctuations and active behavior of living cells

We report the first measurements of the intrinsic strain fluctuations of living cells using a recently-developed tracer correlation technique along with a theoretical framework for interpreting such data in heterogeneous media with non-thermal driving. The fluctuations' spatial and temporal correlations indicate that the cytoskeleton can be treated as a course-grained continuum with power-law rheology, driven by a spatially random stress tensor field. Combined with recent cell rheology results, our data imply that intracellular stress fluctuations have a nearly $1/\omega^2$ power spectrum, as expected for a continuum with a slowly evolving internal prestress.Comment: 4 pages, 2 figures, to appear in Phys. Rev. Let

Identifizierung VHL-assoziierter Veränderungen im klarzelligen Nierenzellkarzinom: Anwendung von kombinierten Genom- und Expressionsanalysen

Zusammenfassung: Das sporadische Nierenzellkarzinom (NZK) ist ein heterogener solider Tumor, der traditionell basierend auf morphologischen Kriterien in weitere Subtypen unterteilt wird. In den letzten Jahren konnten unter Anwendung molekularer Hochdurchsatzanalysen genetische, transkriptionelle und translationale Alterationen identifiziert werden. Diese Marker eignen sich zum einen für die molekulare Klassifizierung des NZK und haben zum anderen prognostische Wertigkeit. Die isolierte Betrachtung genetischer, transkriptioneller und translationaler Veränderungen verhindert jedoch ein tieferes Verständnis für die komplexen Vorgänge der Karzinogenese. Wir fassen hier aktuelle Forschungsergebnisse zur molekularen Charakterisierung des NZK zusammen und stellen ein systembiologisches Konzept zur Identifizierung neuer Tumormarker vor. Diese könnten zukünftig Einsatz in der Diagnostik und Therapie des sporadischen NZK finde

Immunophenotyping without antibodies: New perspectives for lymphoma characterization

Aims: Accurate classification of haematological malignancies is a prerequisite for their correct diagnosis, prognosis and therapy. Clear classification of lymphomas is often hindered by the limited number of available cell surface protein markers that are suitable for immunophenotyping. A systematic and quantitative analysis of cell surface proteins is thus required to identify new protein markers on lymphoma subtypes in an unbiased and discovery-driven approach. Methods: Nine Hodgkin and non-Hodgkin B cell lines of diffuse large cell type and mediastinal type were investigated by cell surface capture (CSC) technology, a mass spectrometry-based method to identify cell surface glycoproteins. Selected proteins are verified by antibody-based methods, including flow cytometry and immunohistochemistry on cell line arrays. Results: A total of 747 predicted transmembrane proteins were identified from all cell lines, including 142 CD (cluster of differentiation) annotated proteins. A group of differentially expressed cell surface glycoproteins between Hodgkin and non-Hodgkin B cell lines was revealed via quantitative CSC technology. In addition to classical and expected CD molecules such as CD20 and CD30, less frequently expressed molecules such as CD2 on Hodgkin lymphoma (HL) cell lines were identified by CSC and verified by immunohistochemistry in cell lines and primary lymphoma tissue. A panel of CSC-identified differentiation glycoprotein candidates is currently under investigation on tissue microarrays (TMAs) from patient sample

Depinning in a Random Medium

We develop a renormalized continuum field theory for a directed polymer interacting with a random medium and a single extended defect. The renormalization group is based on the operator algebra of the pinning potential; it has novel features due to the breakdown of hyperscaling in a random system. There is a second-order transition between a localized and a delocalized phase of the polymer; we obtain analytic results on its critical pinning strength and scaling exponents. Our results are directly related to spatially inhomogeneous Kardar-Parisi-Zhang surface growth.Comment: 11 pages (latex) with one figure (now printable, no other changes

Generalized Dynamic Scaling for Critical Magnetic Systems

The short-time behaviour of the critical dynamics for magnetic systems is investigated with Monte Carlo methods. Without losing the generality, we consider the relaxation process for the two dimensional Ising and Potts model starting from an initial state with very high temperature and arbitrary magnetization. We confirm the generalized scaling form and observe that the critical characteristic functions of the initial magnetization for the Ising and the Potts model are quite different.Comment: 32 pages with15 eps-figure

Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008

A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical manifestations and case management for 26 hospitalised laboratory-confirmed EHF patients. Clinical findings are congruous with previously reported EHF infections. The most frequently experienced symptoms were non-bloody diarrhoea (81%), severe headache (81%), and asthenia (77%). Seven patients reported or were observed with haemorrhagic symptoms, six of whom died. Ebola care remains difficult due to the resource-poor setting of outbreaks and the infection-control procedures required. However, quality data collection is essential to evaluate case definitions and therapeutic interventions, and needs improvement in future epidemics. Organizations usually involved in EHF case management have a particular responsibility in this respect

Development of a highly concentrated perfusion medium supplement to decrease media demand leveraging a newly designed 250 mL single use perfusion bioreactor

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